MOLECULAR MECHANISMS OF CONTRACTION

  • Potter, James D., (PI)
  • Mandel, Frederic (PI)
  • Lane, Lois (PI)
  • Wang, Taitzer (PI)
  • Collins, John (PI)
  • Millard, Ronald (PI)
  • Wallick, Earl (PI)
  • Brown, Truman (PI)
  • Jackson, Richard (PI)
  • Johnson, Carl (PI)
  • Wieczorek, David (PI)
  • Liggett, Stephen (PI)
  • Disalvo, Joseph (PI)
  • Robbins, Jeffrey (PI)
  • Kranias, Evangelia (PI)
  • Varadi, Gyula (PI)
  • Grupp, Ingrid (PI)
  • Schwartz, Arnold (PI)

Project: Research project

Description

This is an application for a renewal of a Program Project Grant,
entitled, "MOLECULAR MECHANISMS OF CONTRACTION". The projects are
designed to elucidate the molecular processes by which critical systems
in the heart regulate the intracellular calcium levels and thus,
myocardial contractility. The information derived is fundamental towards
the understanding of the factors involved in a dysfunctioning heart and
will be valuable in the synthesis of new molecules that may prevent or
reverse the disease processes. The six projects include studies on human heart voltage-dependent calcium
channels, human Na, K-ATPase, myosin, troponin I, phospholamban in the
sarcoplasmic reticulum, and a regulatory atrial apolipoprotein. All the projects are directed towards elucidating structure-function
relationships and understanding regulatory mechanisms at the molecular
level. All use molecular biological strategies and at least three are
designed to extend their studies to an in vivo model and produce
transgenic mice with specific characteristics. The scientific cores include molecular biology, protein chemistry and
transgenic animal cardiovascular dynamics.
StatusFinished
Effective start/end date7/1/786/30/05

Funding

  • National Institutes of Health

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Muscle Contraction
Myocardium
Myosin Type I
Reticulum
Troponin I
Apolipoproteins
Organized Financing
Molecular Biology
Calcium
Proteins

ASJC

  • Medicine(all)