Project: Research project

Project Details


The goals of this study are to identify and evaluate molecular markers
useful in the classification and grading of gliomas. The intended
projects, as listed in the Specific Aims, were selected so as to address
problems in tumor classification whose resolution, we believe, will
significantly improve the diagnosis, and therefore treatment, of patients
with brain tumors. These issues include: (1) the details and diagnostic
specificity of molecular changes in spectrum of pilocystic astrocytomas
arising in both patients with neurofibromatosis 1 and in the general
population without a recognized genetic predisposition to this common
pediatric neoplasm, (2) the presence or absence of similar molecular
changes in sporadic non-pilocystic tumors (high grade fibrillary
astrocytic tumors and oligodendrogliomas) and how these might be related
to tumor classification, (3) the prognostic utility in higher grade
astrocytic neoplasms of the cycling cell marker Ki-67 and amplification
of the epidermal growth factor receptor gene, (4) the genomic
abnormalities associated with tumor progression in fibrillary astrocytic
and oligodendroglial neoplasms, and how these changes can be used in
tumor grading and prognosis, and (5) the determination of tumor extent
(staging) of the untreated glioblastoma by unambiguous molecular methods.
The proposed research benefits from strong interactions with the
multicenter CNS Consortium New Approaches to Brain Tumor Therapy (NABTT).
NABTT will provide ready access to rare tissue resources and the
extensive clinical and scientific data from a large collection of
patients diagnosed with primary gliomas required for our analyses. Our
molecular findings derived from PCR-based highly efficient methods will
be correlated with clinical parameters including the response to specific
NABTT initiated treatments. Close interactions between our Cooperative
Glioma Network multidisciplinary research team and the NABTT will
significantly extend the resources of both studies. These studies will
improve our knowledge of the molecular alterations of these tumors and
provide diagnostic markers that can be correlated with outcome.
Moreover, these data will provide the basis for future studies on the
pathophysiologic mechanisms of gliomas and lead to new approaches to
Effective start/end date1/19/9511/30/00


  • National Cancer Institute
  • National Cancer Institute


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