MOLECULAR BASIS FOR SIV PATHOGENICITY

Project: Research project

Description

Animal models for AIDS are needed to study the pathogenesis of
disease and to facilitate the development of vaccines and drug
therapies. Simian Immunodeficiency Virus (SIV) infection of
macaques promises to be a valuable system for such studies. SIV
is similar to the human AIDS virus HIV in its biological properties,
it is related in sequence to HIV and it induces a disease in
monkeys with remarkable parallels to AIDS in man. Results of
experiments regarding SIV disease pathogensis and vaccine
development could suggest reasonable approaches for human AIDS
prevention. In the proposed research, molecular determinants of SIV
persistence in vivo will be identified and mechanisms by which the
persistent virus carrier state is achieved and maintained will be
examined. These goals will be achieved through in vitro and in
vivo testing of SIV mutants of defined sequence and through
analysis of some of the characteristics of persistent SIV infection.
The role of defined mutations on tropism and pathogenicity will
be examined. Ongoing attempts to achieve protective immunity
through vaccination will be extended.
StatusFinished
Effective start/end date9/1/873/31/12

Funding

  • National Institutes of Health
  • National Institutes of Health: $402,453.00
  • National Institutes of Health: $443,111.00
  • National Institutes of Health: $405,510.00
  • National Institutes of Health: $456,405.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $402,453.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $313,054.00
  • National Institutes of Health: $398,429.00
  • National Institutes of Health: $422,500.00
  • National Institutes of Health: $430,205.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $337,142.00
  • National Institutes of Health
  • National Institutes of Health: $417,675.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $410,248.00
  • National Institutes of Health: $362,716.00

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Virulence
Simian Immunodeficiency Virus
Virus Diseases
HIV
Acquired Immunodeficiency Syndrome
nef Genes
Lymphocyte Activation
Viruses
HIV-1
Carrier State
Antibodies
Macaca mulatta
Neutralizing Antibodies
Tropism
Antibody Formation
Haplorhini
Vaccines
Infection
AIDS Vaccines
nef Gene Products

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)