MENTORED PATIENT-0RIENTED RESEARCH CAREER DEVELOPMENT AW

Project: Research project

Project Details

Description

(Adapted from the applicant's abstract): SCI predispose to glucose
intolerance and insulin resistance, presumably due to changes in body
composition and skeletal muscle dysfunction, placing SCI individuals at
greater risk for diabetes and coronary artery disease. In the able-bodied,
marked improvements in glucose tolerance have been reported in response to
aerobic exercise, with variable changes in insulin sensitivity. Resistance
training has also improved glucose tolerance, and to a greater extent, insulin
sensitivity in the able-bodied. Exercise responses in SCI have not been
examined as extensively as they have in the general population, and yet this
population has significantly more to gain than the able-bodied population by
improving metabolic and functional abilities. The proposed hypothesis is that
aerobic exercise, resistance training and/or a combination of aerobic exercise
and resistance training will improve body composition and glucose tolerance,
but only exercise which involves resistance training, and subsequent increases
in muscle mass, will significantly improve insulin sensitivity in individuals
with SCI. Twenty individuals with motor complete T6-L2 SCI will be recruited
each year to participate in one of the following exercise protocols. Subjects
will be randomly assigned to control or aerobic (Trial 1), resistance (Trial
2), and combined (Trial 3) exercise groups. Glucose tolerance, insulin
sensitivity and body fat will be determined before and after each of the
exercise interventions.

If glucose intolerance and subsequently diabetes mellitus can be prevented in
individuals with SCI by utilizing appropriately dosed exercise, significant
savings in health care dollars and improved quality of life could be realized.
StatusFinished
Effective start/end date9/29/008/31/05

Funding

  • National Center for Research Resources: $36,466.00
  • National Center for Research Resources: $76,344.00
  • National Center for Research Resources: $76,344.00
  • National Center for Research Resources: $128,323.00
  • National Center for Research Resources: $76,344.00
  • National Center for Research Resources: $43,473.00

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