Mechanisms of mucosal protection induced by attenuated SIV

Project: Research project

Project Details

Description

Lack of information on mechanisms of protection against HIV/SIV infection remains one of the leading
obstacles to the development of a safe and effective AIDS vaccine. Vaccination of macaques with
attenuated SIV strains has consistently proved to be the most effective means of inducing protection against
pathogenic SIV challenge and offers the best available experimental model to define specific mechanisms
responsible for protection. Previous studies from our group have provided evidence that SIV-specific CD8+ T
cell and humoral responses both contribute to protective immunity induced by SIVAnef but have not been
able to assess their relative importance or the potential contributions of novel adaptive (eg CD4+ T effector
cells) or innate immune responses to protection. The goal of the current proposal is to utilize a number of
novel techniques to carry out a comprehensive analysis of the role of adaptive and innate immune responses
in mediating protection induced by SIVAnef against vaginal challenge, one of the most important modes of
HIV transmission. Specific aims include: 1: To examine the evolution of adaptive and innate immune
responses induced by SIVAnef and to correlate these responses with protection against homologous and
heterologous challenge. 2: To examine the effect of prolonged B cell depletion on protective immunity
induced by SIVANef. 3: To examine viral replication, innate and adaptive immune responses in the female
reproductive tract of SIVAnef-vaccinated animals after vaginal challenge.
StatusFinished
Effective start/end date1/1/073/31/14

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)

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