Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease

  • Romano, Jose G (PI)
  • Prabhakaran, Shyam (PI)
  • Liebeskind, David Sigmund (PI)

Project: Research project

Description

DESCRIPTION (provided by applicant): Intracranial atherosclerotic disease (IAD) causes about 10% of strokes in the US, and up to 50% of strokes in China and Southeast Asia, and may be the most important cause of ischemic stroke worldwide; furthermore, it carries a risk of early recurrence as high as 25% at 1 year. The mechanisms of stroke in IAD remain unclear, and unraveling the distinct ischemic mechanisms may lead to risk stratification and the development of targeted therapies for IAD. The objective of this study is to determine the mechanisms of stroke in patients with IAD by specifically evaluating limitations of flow through the stenotic artery, distal tissue perfusion to the affected territory, and artery-to-artery embolim, as well as specific interactions between these mechanisms. This prospective multicenter study will enroll 175 patients with recently symptomatic (
StatusFinished
Effective start/end date3/1/142/28/19

Funding

  • National Institutes of Health: $625,883.00
  • National Institutes of Health: $568,339.00
  • National Institutes of Health: $700,066.00
  • National Institutes of Health: $575,773.00
  • National Institutes of Health: $540,419.00

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Stroke
Recurrence
Arteries
Southeastern Asia
Multicenter Studies
China
Perfusion
Prospective Studies
Therapeutics

ASJC

  • Medicine(all)
  • Neuroscience(all)