Marine and Freshwater Biomedical Sciences Center

  • Baden, Daniel (PI)
  • Walsh, Patrick Joseph (PI)
  • Fleming, Lora E (PI)

Project: Research project

Project Details


DESCRIPTION (provided by applicant)
This proposal is to provide continued funding of an NIEHS Marine and
Freshwater Biomedical Sciences Center at the University of Miami. Based at
the Rosenstiel School of Marine and Atmospheric Sciences campus, the Center is
it collaborative effort of 19 investigators from three University of Miami
campuses and 6 external organizations. Two principal research themes form the
basis for interdisciplinary Research Cores: "Marine and Freshwater Toxins and
Human Health " and "Marine and Freshwater Animal Models Toxins and Human
Health ". Both research themes are within the scope of NIEHS-sponsored
research and contribute to the overall mission of the University of Miami
Marine and Freshwater Biomedical Sciences Center: to evaluate the impact of
the oceans and freshwater bodies on human health, by assessing and
understanding risks, and by seeking remedies. The first research core
includes: Toxin Biosynthesis and Probe Development, Metabolism, Molecular
Pharmacology, Molecular Modeling, Electrophysiology Receptor Binding,
Separation Techniques and Assay Methods, and Epidemiology and Public Health.
The second research core includes several marine and freshwater (and human)
models in various stages of development: Damselfish Neurofibromatosis,
Cultured Human Schwann Cells, Aplysia Neurophysiology, Toadfish
Hyperammonemia, Transgenic Fishes, Squirrelfish Zinc Metabolisin/Transport,
Fish Immunology arid Sentinel Species. A vigorous Pilot Project Program is
represented by four recently selected applications on: "Functional Analysis of
Zinc Regulatory Genes in Transgenic Zebrafish"; "Red Tide Toxin Effects on
Hearing: a Vertebrate Model"; "Molecule-Based Sensors for Carcinogenic
Pollutants"; and "Microbial Recreational Water Indicators in the Subtropical
Marine Environment". In support of existing individual and collaborative
programs, 4 Facilities and Service Cores are proposed based on the
investigators? evaluation of utilization and overall value to programs in the
past five years: Toxin Probes, supplying brevetoxins, saxitoxin, okadaic acid,
domoic acid, ciguatoxins and application-related toxin derivatives, as well as
cultures of toxin organisms, and DNA-based materials from these organisms; In
vitro and In vivo Fish Culture supplying facilities and expertise or the
maintenance of, and experimentation with, fish and invertebrate cell cultures
and live organisms; Analytical Chemistry and Electron Microscopy, which
provides NMR, MS and analytical separation techniques assistance, and access
to several EM methodologies; Neurophysiology, which provides two separate
fully-equipped electrophysiology rigs, as well as additional tissue culture
support capability. A well developed Community Outreach and Education Program
will continue, including a poison-control hotline for seafood intoxication, an
NIEHS-sponsored K-12 education program, and an NIEHS-sponsored postdoctoral
training program. University of Miami will continue its commitment to the
Center in the form of cost-share for salary support, instrumentation matching
funds, and a faculty start-up package. Through the combined proposed NIEHS
support and UM cost share, the investigators will continue to perform basic
research on toxins and animal models, and to communicate the NIEHS message to
the scientific and lay communities.
Effective start/end date8/10/923/31/07


  • National Institute of Environmental Health Sciences: $385,389.00


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