• Jope, Richard S (PI)

Project: Research project

Project Details


This project uses electrophysiological and biochemical methods to
study a new model of status epilepticus. This model uses
pretreatment with lithium followed by administration of
subthreshold doses of convulsants. The basic model entails
treatment with LiCl (3 mEq/kg; ip) and pilocarpine (30 mg/kg; sc)
which invariably produces generalized convulsive status epilepticus
which lasts for several hours and is fatal. There are three major
goals of this proposal. (1) We will test the hypothesis that lithium lowers the seizure
threshold to other convulsive stimuli, including ECS, bicuculline,
picrotoxin, pentylenetetrazole, kainic acid and chemical
(carbachol) and electrical kindling. (2) We will test the hypothesis that function of the GABAergic
system is impaired during status epilepticus by measuring the state
of the GABA/benzodiazepine/picrotoxin chloride channel complex
during seizures. (3) We will test the hypothesis that alteration of calcium
homeostatis plays a role in status epilepticus by testing the
anticonvulsant and proconvulsant actions of calcium antagonists and
a calcium agonist, respectively, and the effects of seizures and
drug treatments on calcium homeostasis in synaptosomes.
Effective start/end date12/1/8811/30/91


  • National Institutes of Health


  • Medicine(all)
  • Neuroscience(all)


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