INHIBITION OF HIV 1 USING A MUTANT TRNA PRIMER

Project: Research project

Project Details

Description

DESCRIPTION: (adapted from the investigator's abstract) This is a proposal
for funds to investigate the inhibition of retroviral replication through
interference with the normal process of priming. The investigator suggests
that this approach is a novel anti-retroviral approach and also provides a
powerful tool for dissecting molecular aspects of priming. The proposal
focuses on the molecular and virological mechanisms underlying inhibition of
HIV-1 replication by mutant tRNAs. The investigator plans to pursue three
specific objectives: First, he will elucidate the mechanism(s) by which
mutant tRNA expression leads to marked suppression of HIV-1 replication and
use this knowledge to design second generation tRNA mutants with enhanced
ability to inhibit HIV-1 replication; second, he will analyze virus
recovered from mutant tRNA-transduced cells for potential escape mechanisms;
and third, he will examine the effect of mutant tRNA-based inhibition in
combination with anti-viral drugs which target reverse transcription.
StatusFinished
Effective start/end date7/1/9712/31/01

Funding

  • National Institute of Allergy and Infectious Diseases
  • National Institute of Allergy and Infectious Diseases: $192,454.00
  • National Institute of Allergy and Infectious Diseases
  • National Institute of Allergy and Infectious Diseases

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