INHIBITION OF HIV 1 USING A MUTANT TRNA PRIMER

Project: Research project

Description

DESCRIPTION: This is a proposal for funds to investigate the inhibition of retroviral replication through interference with the normal process of priming. The investigator suggests that this approach is a novel anti-retroviral approach and also provides a powerful tool for dissecting molecular aspects of priming. The proposal focuses on the molecular and virological mechanisms underlying inhibition of HIV-1 replication by mutant tRNAs. The investigator plans to pursue three specific objectives: First, he will elucidate the mechanism(s) by which mutant tRNA expression leads to marked suppression of HIV-1 replication and use this knowledge to design second generation tRNA mutants with enhanced ability to inhibit HIV-1 replication; second, he will analyze virus recovered from mutant tRNA-transduced cells for potential escape mechanisms; and third, he will examine the effect of mutant tRNA-based inhibition in combination with anti-viral drugs which target reverse transcription.
StatusFinished
Effective start/end date7/1/9712/31/01

Funding

  • National Institutes of Health: $176,123.00
  • National Institutes of Health: $192,454.00
  • National Institutes of Health: $186,849.00
  • National Institutes of Health

Fingerprint

Transfer RNA
HIV-1
Research Personnel
Financial Management
Reverse Transcription
Viruses
Pharmaceutical Preparations

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)