INFANTS OF HTLV-III/LAV SEROPOSITIVE MOTHERS

Project: Research project

Description

Among recent Haitian emigrants living in Miami the prevalence of serum
antibodies to HTLV-III/LAV is 2-9%. Haitian-born women deliver between
2200 and 2500 infants annually at Jackson Memorial Hospital in Miami;
approximately 20 of these infants will develop clinical evidence of
HTLV-III/LAV infection each year. These deliveries constitute at least 90%
of all births among Haitian emigrants in Dade County. We propose to
determine the proportion of seropositive mothers that give birth to
seropositive, virus-positive infants that develop clinical syndromes
associated with HTLV-III/LAV infection. Seropositive and seronegative
infants of seropositive mothers will be followed with a comparable number
of seronegative infants of seronegative mothers for two years to assess
their outcome. Information obtained from this population-based study will
be of significance in two major areas. First, the information from the
mothers will be used to assess the risks to unborn infants of women with
HTLV-III/LAV infection. Second, the population-based character of the
study will provide more complete information on the clinical spectrum of
HTLV-III/LAV infection among infants in this population.
StatusFinished
Effective start/end date3/1/865/31/97

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $41,237.00
  • National Institutes of Health
  • National Institutes of Health: $1,071,298.00
  • National Institutes of Health: $464,391.00
  • National Institutes of Health: $997,883.00
  • National Institutes of Health

Fingerprint

Mothers
HIV-1
Infection
Population
HIV
Parturition
Disease Progression
Prospective Studies
HIV-2
HIV Infections
Viruses

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)