IMMUNE AND VIRAL CORRELATES OF PEDIATRIC HIV PROGRESSION

Project: Research project

Project Details

Description

DESCRIPTION: The primary hypothesis under investigation is that humoral
and cellular immune responses will affect the biological properties and
genetic characteristics of HIV and alter disease progression. The
proposed studies will utilize available specimens from a cohort followed
longitudinally since 6 months of age or earlier, and focusing primarily
on slow progressors and rapid progressors. The Specific Aims of this
application are: (1) to study the natural history of humoral immune
responses through quantitation of binding antibodies to core and
envelope, quantitation of autologous and heterologous neutralizing
antibody, and detection of ADCC; (2) to determine the role of cellular
immunity in disease progression through characterization of T cell
receptor utilization and CTL; (3) to study the biological properties of
virus over time as it relates to disease progression by determining viral
burden, host cell range and syncytia production.
StatusFinished
Effective start/end date3/1/962/28/02

Funding

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $283,850.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development

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