Identification of Protein-Protein Interactions and Processing Events That Traffic and Activate the Bactericidal Pore-Forming Protein Perforin-2

The phagocytosis and destruction of microorganisms is an essential function of phagocytes that protects us from invading pathogens. This application will further our understanding of this process by further elucidating a mechanism for the destruction of phagocytosed bacteria that was unknown to science and medicine until relatively recently.