Project: Research project

Project Details


DESCRIPTION: (provided by applicant) This application proposes to investigate
the mediating role of endocrine consequences on the occurrence of mental health
outcomes that take place among HIV-1+ IDUs. Injecting drug use (IDU) is one of
the major risk factors for contracting human-immunodeficiency virus, type-i,
(HIV-1) infection. abnormalities in various endocrine systems develop in IDUs
and HIV-1+IDUs and may be associated with number of mental health outcomes. Our
earlier reports show that the ACTH and cortisol responses to a cold pressor
challenge are attenuated in HIV-1 + individuals and, thus, support the proposed
hypothesis. An array of outcomes including, anxiety, depression, and perceived
psychological distress and difficulty adapting to stressors occurs in HIV-1 +
IDUs. Since HIV is present in the brain soon after infection and esides in very
high concentrations in the hippocampus, it is proposed that different endocrine
systems are likely to be adversely impacted centrally in HIV-1 infection. It is
important to understand the mechanisms involved in the development of
neuroendocrine abnormalities - central or peripheral - in order to intervene n
mental health-related problems.

This five-year proposal investigates the responses of the thyroid and gonads to
trophic hormones, hyroid releasing hormone (TRH), and luteinizing
hormone-releasing hormone (LHRH), as well as adrenal Aictivity in response to a
low-dose ACTH challenge. This investigation will be carried out using a
crossectional three-group design (HIV-i+ lDUs, N+1OO, HIV-1- IDUs, N=100, and
HIV-1- non-IDUs, N=100) with the total N = 300, X 3 ethnicitlies
(African-Americans, Hispanics, Caucasians) X 2 genders (Women and Men). Only
those HIV seropostiive subjects who do not have AIDS-defining symptoms and are
not being treated with triple-drug therapy will be enrolled since the effect of
triple-drug therapy on the endocrine system is unknown at this time. It is
proposed to investigate whether the endocrine responses nediate mental health
outcomes (i.e., depression, anxiety, and perceived psychological distress).
These data will be useful in designing suitable interventions.
Effective start/end date5/1/014/30/08


  • National Institute on Drug Abuse: $645,088.00
  • National Institute on Drug Abuse: $94,371.00
  • National Institute on Drug Abuse: $87,815.00
  • National Institute on Drug Abuse: $579,678.00
  • National Institute on Drug Abuse: $719,416.00
  • National Institute on Drug Abuse: $561,456.00
  • National Institute on Drug Abuse: $752,274.00


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