HIV-1 &HIV-2 CO-INFECTI0N: NEUROLOGICAL PROGRESSION

Project: Research project

Project Details

Description

DESCRIPTION (Provided by applicant): The main objective of this application is
to investigate the prevalence and progression of neuroendocrinologic and
neurological complications associated with HIV-infection in South India. The
first case of HIV-infection was reported in1987 from the Christian Medical
College, (CMC) Vellore, India the site of this proposed research project. Over
the years, HIV-infection has spread aggressively and there are estimated to be
at least 4.1 million HIV-infected individuals in India. It is estimated that
during the next 5-10 years the number of infected individuals in India may
exceed the present prevalence of the entire world and pose an international
public health threat. Surprisingly, up to 25 percent of infected individuals in
India have co-infections of both HIV-1 and 2.

Immediately after infection, HIV crosses the blood-brain-barrier and is
localized in very high concentrations in the hippocampus and to variable
degrees in other areas of the brain. Since the hippocampus plays an important
role in regulating various endocrine systems, memory and other neurological
functions, this application proposes to investigate longitudinally the
prevalence of abnormalities in these systems as associated with the progression
of HIV-1 & HIV-2 co-infection as well as with HIV-1 or HIV-2 mono-infections in
the catchment area of CMC. This study will follow N= 240 individuals; HIV-1/2
co-infected, N= 60; HIV-1+, N=60; HIV-2+, N=60; and HIV-seronegative
individuals, N=60. Both men and women, age 20-45, will be enrolled and followed
for up to 3 years at six -month intervals. Abnormalities in the endocrine
systems will be investigated via norepinephrine, epinephrine, ACTH and cortisol
responses to an alpha-adrenergic challenge, AM and PM plasma levels of
endocrines and CSF levels of cytokines and hormones. Using path analytic
procedures, endocrine functions will be tested as mediators of the progression
of neuropsychiatric and neuropsychology impairments determined using
standardized cognitive test batteries.

The data will be useful in designing interventions and for instituting an
effective health policy.
StatusFinished
Effective start/end date9/28/017/31/09

Funding

  • National Institute of Neurological Disorders and Stroke: $454,502.00
  • National Institute of Neurological Disorders and Stroke: $462,805.00
  • National Institute of Neurological Disorders and Stroke: $476,725.00
  • National Institute of Neurological Disorders and Stroke: $446,249.00
  • National Institute of Neurological Disorders and Stroke: $489,799.00

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