Project: Research project

Project Details


The Program Project is designed to use modern genetic approaches in the
study of key components and events in the development, function, and repair
of the vertebrate central nervous system. Major areas of molecular
neuroscience to be studied include cell-cell interactions (Project 1),
signaling via intracellular second messenger systems (Project 2), and genes
that contribute to nervous system pattern formation (Project 3). The
approaches to be used include creation of animals with specific germ line
mutations by homologous recombination in embryonic stem cells, analysis of
the fate of individual mutant precursor cells in a normal tissue
environment, and identification of specific disease genes by newly devised
methods utilizing the mapping of overlapping deletions.

This program requires a synergistic and innovative application of the
expertise represented by several investigators, with integration of this
expertise at both the technical and interpretive stages of each project.
Integration is facilitated through three Cores: Administrative, Gene
Targeting, and Phenotypic Analysis, that are utilized by each project and
provide for unusual economy of effort and expense in this type of research
. The combination of results obtained in analysis of the different systems
described will provide for a more comprehensive understanding of molecular
systems at the tissue level in the intact animal. This body of fundamental
information on the assembly and function of the central nervous system is
of direct relevance to human health problems concerning defects in brain
development and the resulting dysfunction and mental retardation.
Effective start/end date5/16/954/30/01


  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke


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