FUNCTIONAL ANALYSIS OF ADIPOCYTE LIPID BINDING PROTEIN

  • Smith, Elizabeth R, (PI)

Project: Research project

Description

The goal of the proposed research is to determine the function of the adipocyte fatty acid binding protein (AFABP) in the transport and metabolism of fatty acids in adipose tissue. Fatty acid trafficking is central to the ability of adipose tissue to store and mobilize energy, and imbalances in the control of fatty acid metabolism accompany obesity, insulin resistance, and diabetes. AFABP is believed, but have never been directly proven, to be centrally important in the transport of fatty acids. This study utilizes transgenic mice in which the AFABP gene has been disrupted by homologous recombination and which lack the AFABP protein. Given the abundance and tissue-specificity of AFABP, the absence of the protein should alter adipocyte lipid homeostasis. Using the AFABP-knockout mice, the proposed research will investigate the role of AFABP in fatty acid transport into and within adipocytes, as well as in the regulation of white and brown adipocyte lipid metabolism.
StatusActive
Effective start/end date3/1/96 → …

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Fatty Acid-Binding Proteins
Adipocytes
Fatty Acids
Adipose Tissue
White Adipocytes
Brown Adipocytes
Organ Specificity
Homologous Recombination
Protein Transport
Lipid Metabolism
Research
Knockout Mice
Transgenic Mice
Insulin Resistance
Proteins
Homeostasis
Obesity
Lipids

ASJC

  • Medicine(all)