Project: Research project

Project Details


DESCRIPTION: (Applicant's Abstract)
This application proposes to conduct a Stage I treatment development study that
targets Hispanic drug abusing adolescents and their families, who have unique
values and acculturation/ immigration related life experiences that can be
shown to directly impact engagement, retention, drug use, and the
efficacy/effectiveness of drug treatment. Although the importance of culture
related factors have been generally acknowledged, treatment models have failed
to link specific culturally derived interventions to specific treatment change
mechanisms central to drug abuse treatment. The proposed model, Culturally
Rooted Adolescent Family Therapy (CRAFT), will include psycho-educational
modules that directly address these culture related factors and are designed to
enhance treatment alliance and facilitate the work of family therapy change

The proposed model is divided into three AIMs each designed to produce findings
that inform the subsequent AIM's work. AIM I consists of a basic research study
that investigates the independent contribution of specific immigration and
acculturation-related stressors in disrupting family therapy mechanism of
change. AIM II consist of: 1) the development of a "working" CRAFT manual, 2) a
set of single-case experiments designed to enhance the impact on family change
mechanism and CRAFT's feasibility/acceptability, 3) the manualization of the
refined CRAFT model, and 4) the development of an adherence checklist and
therapist selection and training guidelines. AIM III focuses on pilot testing
the efficacy of the manualized intervention using a small randomized trial
design in which subjects are randomized to either CRAFT or Family Therapy as

AIM I analyses of the basic research study and the AIM II single-case
experiments series are intended to provide data that will inform the
refinements of the CRAFT intervention. AIM III analyses of the randomized trial
are designed to determine effect sizes for the analyses that would be required
in a Stage II efficacy trial, viz., HLM on outcomes (drug abuse and other
delinquency problems); HLM analyses of postulated change mechanisms (parent
practices, parent-adolescent attachment, parent-ecology interactions, and
therapeutic alliance). Moreover, analyses of clinical significance will be used
to identify subgroups for whom the interventions work best, and growth curve
analyses using Hierarchical Linear Modeling, will be used to compare the
trajectory of change in mechanisms of action between successful and
unsuccessful cases.
Effective start/end date8/5/007/31/06


  • National Institute on Drug Abuse: $626,897.00
  • National Institute on Drug Abuse: $611,378.00
  • National Institute on Drug Abuse: $37,360.00
  • National Institute on Drug Abuse: $514,064.00
  • National Institute on Drug Abuse: $324,098.00


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