Project: Research project

Project Details


Information on tissue metabolites obtained by in vivo proton magnetic
resonance spectroscopy (MRS) offers considerable potential for clinical
diagnosis and biomedical research. Analysis of this data benefits from
parametric modeling methods that use a priori spectral information. We
have previously used computer simulation methods to obtain detailed
spectral information, using parameters measured by high-resolution NMR
of metabolites in solution. Improvements of the spectral model are
needed to account for additional signal contributions, and differences
in the in vivo environment or metabolite conformations.

A goal of this project is accurate characterization of the NMR
parameters of metabolites and other signal contributions observed with
in vivo 1H MRS in brain, in order to improve the accuracy of parametric
spectral analysis. Studies will be carried out using high-resolution
NMR of metabolites in solution, in tissue homogenates, and in vivo.
Additional studies will characterize the macromolecular contributions
to spectra of brain, which will also be incorporated into the parametric
signal model to further improve the spectral analysis.

A second goal of this study is the development of methods for
classification of large amounts of in vivo spectra, such as that
obtained for clinical MR spectroscopic imaging studies using automated
parametric spectral analysis. Supervised and unsupervised methods will
be used to probabilistically identify each voxel with multiple possible

This work will extend clinical MRS applications by providing increased
accuracy and information on the intracellular environment. This
development will support ongoing clinical studies investigating changes
of brain metabolites associated with Alzheimer's disease and aging,
epilepsy, and multiple sclerosis.
Effective start/end date2/1/021/31/04


  • National Institute of Biomedical Imaging and Bioengineering: $135,914.00
  • National Institute of Biomedical Imaging and Bioengineering: $246,437.00
  • National Institute of Biomedical Imaging and Bioengineering: $120,596.00


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.