CYTOKINES--THEIR ROLE IN COXSACKIE VIRUS B3 MYOCARDITIS

Project: Research project

Description

The research discussed in this grant proposal addresses the role of
cytokines in the development of acute phase viral myocarditis and late
phase autoimmune myocarditis in CB3- infected susceptible A/J mice, a
model of human coxsackievirus myocarditis. Experiments will examine local
production of cytokines in the heart in response to CB3 infection or
myosin immunization. The effects of cytokines on inflammatory cell
populations and their activity, and the effects of cytokines on cardiac
myocyte contractility and physiology will be examined. The effect of
anticytokine therapy on the development of myocarditis will also be
examined. All research will be conducted in the Johns Hopkins School of Hygiene and
Public Health. The laboratories are well equipped, and contain all
equipment necessary to complete the described experiments.
StatusFinished
Effective start/end date12/1/7711/30/07

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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irinotecan
Myocarditis
Cytokines
Pharmacokinetics
Paclitaxel
Enterovirus
Organized Financing
Hygiene
Research
Immunization
Health
Infection