• Kasahara, Noriyuki (PI)
  • Sachs, George (PI)
  • Reeve, Joseph (PI)
  • Sternini, Catia (PI)
  • Jensen, Dennis (PI)
  • Walsh, John (PI)
  • Tache, Yvette France (PI)
  • Rozengurt, Juan Enrique (PI)
  • Reeve, Joseph (PI)
  • Sternini, Catia (PI)
  • Jensen, Dennis Michael (PI)

Project: Research project

Project Details


The UCLA-CURE Digestive Disease Core Center is organized around a cohesive
group of senior investigators who have strong independent research
programs in upper gastrointestinal tract biology and/or mucosal disease.
Specifically, these investigators are studying the role of peptide
hormones and neuropeptides in regulation of gastric secretion, blood flow
and emptying; regulation of parietal cell function and the biochemical
mechanisms responsible for acid secretion; mechanisms for cellular
transport of essential nutrients, including glucose, and of cytoprotective
substances, particularly glutathione; and control of acute bleeding from
peptic ulcers and long term prevention of recurrent ulcer disease. The major functions of the Center are to foster productive scientific
interactions between members of the research groups, to develop new
programs, and to provide a milieu in which young investigators can enhance
their training and develop their careers. The six scientific cores outlined in this proposal provide ready access to
technology and to clinical biological materials that are essential to the
programs of Center members. These cores provide custom synthesis of
peptides and methods for purifying and characterizing them including
custom antibody production; sophisticated animal models for studies of
gastric secretion, motor function, and blood flow; anatomical methods for
identification of proteins,
mRNA, and receptors; and imaging techniques to study intracellular
responses to modifiers of cellular function as well as a clinical studies
core. An administrative core provides general coordination of Center
activities and additionally offers to all members computer and graphics
services, grants management, and a dynamic enrichment program. Six pilot
and feasibility study proposals add an innovative dimension to the
Center's research parameters. Funding of this center grant will provide the resources and the
environment to ensure enhanced collaborations among investigators. In
addition, it will provide the milieu for a coordinated comprehensive
training program that can take young investigators through a continuum
from postdoctoral fellowships, through the invaluable experience of
carrying out a pilot and feasibility study, to the ultimate goal of
developing independent laboratory programs. Finally, a cohesive center
setting allows a creative enrichment program to prosper. CURE investigators already have made a major impact in the peptic
disease/mucosal biology field during the last 15 years. The Center will
offer new areas of emphasis, relevant to the current interests of the
participants, better organization, and a renewed spirit of cooperative
Effective start/end date1/15/9011/30/20


  • National Institutes of Health


  • Medicine(all)


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