• Stack, Richard S (PI)

Project: Research project

Project Details


The research tests the hypothesis that coronary flow reserve as
measured by the reactive hyperemic response of coronary
arteries in humans contains important information about the
physiologic significance of epicardial coronary arterial lesions
which could influence patient selection for revascularization
procedures and patient management. This project has eight
specific aims: (1) to develop and validate a thermistor flow
probe for safely determining coronary blood flow velocity in
patients during routine cardiac catheterization. This will involve
in vitro as well as in vivo canine experiments, (2) to use the
thermistor flow probe to develop and validate an easy to use
anemometric method for determining exactly coronary lesion
percent stenosis, (3) to establish the range of normal human
coronary blood flow velocity and coronary vasodilator reserve
capacity using the thermistor flow probe, (4) to correlate
coronary flow reserve with several quantitative angiographic
lesion-associated variables, (5) to document the changes in
coronary flow reserve immediately after percutaneous
transluminal coronary angioplasty (PTCA), (6) to correlate
coronary flow reserve with exercise left ventricular (LV) wall
motion abnormalities using radionuclide ventriculography, (7) to
evaluate the no-reflow phenomenon by examining the effect of
prolonged myocardial ischemia on coronary flow reserve
measured immediately, and 3 months following acute reperfusion
of patients with acute myocardial infarction, (8) to determine
the rapidity with which coronary collateral channels begin to
function during brief coronary artery occulsions in man.
Effective start/end date9/1/878/31/90


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)


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