CONGENITAL TOXOPLASMOSIS &MATERNAL HIV-1 INFECTION

Project: Research project

Description

We propose to conduct a prospective cohort study to determine whether
infants born to women dually infected with both the Human Immunodeficiency
Virus Type I(HIV- 1) and Toxoplasma are at increased risk for congenital
toxoplasmosis. As opposed to the usual clinical situation where congenital
Toxoplasma infection occurs only when the mother is primarily infected
during gestation, women latently infected with Toxoplasma and
immunosuppressed by concurrent HIV-1 infection have been observed to
deliver infants with congenital toxoplasmosis. The background rate of
congenital toxoplasmosis in the United States is low (1/1000 to 1/3000 live
births). Considering that a sizable percentage of HIV-1 infected mothers
may be seropositive for Toxoplasma(38% of 471 Haitian women screened to
date) and that many of these may have deficient cell-mediated immunity,
reactivation of encysted organism associated with intermittent or chronic
parasitemia may be a recurrent event. The frequency of transplacental
transmission of Toxoplasma in this situation therefore may exceed the
background rate of congenital infection secondary to primary infection in
seronegative women. This study will compare the rate of congenital
Toxoplasma infection in a group of infants born to women infected with both
HIV-1 and Toxoplasma with the rate of congenital infection in a group of
infants born to women infected with Toxoplasma only. These rates will also
be compared with the rate of acquired Toxoplasma infection in infants not
at risk for congenial toxoplasma infection.
StatusFinished
Effective start/end date9/1/907/31/93

Funding

  • National Institutes of Health: $35,523.00
  • National Institutes of Health

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Congenital Toxoplasmosis
Toxoplasma
HIV-1
Mothers
Infection
Toxoplasmosis
Coinfection
Cellular Immunity
HIV Infections
Cohort Studies
Prospective Studies
Pregnancy

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)