• Lippman, Marc E (PI)

Project: Research project

Project Details


Breast cancer and prostate cancer are overwhelmingly the most common
hormone dependent malignancies of men and women. Substantial progress has
been made in research leading to identification of specific genetic
elements whose mutation, deletion, amplification or rearrangement
contribute to the pathogenesis of the diseases. This includes both new
data on expression of dominantly acting oncogenes such as erbBl, erbB2, and
erbB3, and the loss of repressive genetic elements such as NM23, P53, and
Rb. The mechanisms by which these genetic elements interact with
proliferative controls to induce abnormal growth and malignant behavior is
also rapidly advancing. This meeting will be aimed at developing consensus
on the mechanisms of involvement of these genetic elements in breast and
prostate disease and the impact of this information on approaches to
diagnosis, prognosis, and therapy. A central, novel feature of this
meeting will be to assemble scientists interested in both breast and
prostate cancer to facilitate cross-fertilization of ideas. Both breast
and prostate cancer depend upon steroid hormones for onset and progression.
Progression of both cancer types also depends on interaction of growth
factors and progressive genetic changes in oncogenes and anti-oncogenes.
This conference provides a unique opportunity to invite the leaders in
cellular and molecular studies of each field to compare data, modify their
working hypotheses of regulation of malignancies, and discuss new
therapeutic approaches. These two diseases together afflict approximately
10% of both men and women and have remarkable similarities in the biology
of their onset and in therapeutic strategies.
Effective start/end date1/1/9212/31/92


  • National Institutes of Health: $10,000.00


  • Medicine(all)


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