Project: Research project

Project Details


DESCRIPTION: (Adapted from the application abstract) A better understanding
of the pathogenesis of AIDS will facilitate drug and vaccine development.
Recent data have shown that large amounts of HIV-1 are produced and
destroyed each day. Antiviral drugs have been able to greatly reduce the
level of virus replication, and the steady state viral burden, until
resistant variants emerge to return virus burdens to pre-drug levels.
Replication competent, nonpathogenic deletion mutants of SIV have provided
solid vaccine protection against challenge by pathogenic virus. Viral
and/or host factors may contribute to long-term nonprogression in rare HIV-1
infected individual. Despite these and other advances on a variety of
fronts, scientist do not adequately understand the basic mechanisms by which
HIV is able to continue to replicate in the face of an apparently strong
host immune response. They have not adequately learned how to combat the
insidious ability of SIV and HIV to mutate, to tolerate mutations, and to
use mutant forms to the advancement of the virus and the detriment of the
host. The immunological mechanisms responsible for protection induced by
live attenuated deletion mutants or in long-term nonprogressing survivors is
unclear. The goal of the meeting is to bring together the leading experts
in the field of AIDS pathogenesis to present their latest results that bear
on these problems.
Effective start/end date4/1/973/31/98


  • National Institute of Allergy and Infectious Diseases


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