CEREBRAL VASCULAR DISEASE

Project: Research project

Project Details

Description

The objective of our research program is to conduct an integrated
multidisciplinary inquiry into the mechanisms and treatment of ischemic
brain injury. Our investigations, grounded in experimental animal models
of cerebral ischemia, have as their ultimate goal the identification of
those factors responsible for ischemic injury which may be amenable to
therapeutic or prophylactic intervention. The Program Project consists
of six investigative proposal together with Core facilities supporting
the research program in the areas of brain metabolite analysis, animal
physiology, radioisotopic tracer strategies, morphology, computer
science/image-processing, and animal behavior. The Cores contribute
substantively to the implementation of each Project and unify the
Projects by common methodological approaches. Program areas include:
(1) treatable mechanisms of brain injury in foal cerebral ischemia; (2)
mechanisms of functional recovery following cerebral infarction; (3) an
analysis of glutamatergic mediation of ischemic vulnerability; (4) the
effect of mild selective cerebral hypothermia in protecting against
ischemic brain injury; (5) studies of early indices of cellular damage in
the hippocampal slice preparation; and (6) an analysis of local cortical
electrophysiological and ion-transport alterations in acute focal
cerebral ischemia and their relationship to ultimate tissue injury.
StatusFinished
Effective start/end date12/31/897/31/95

Funding

  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke

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