CELL MEDIATED IMMUNITY IN MAMMARY TUMOR MODELS

Project: Research project

Description

The development of breast cancer can be modulated by the actions of the
immune system. Reciprocally, mammary tumors appear to cause profound
alterations on the immunologically relevant cells, either directly, via
tumor cell derived factors, or in an indirect manner. We propose to
continue our studies to elucidate the interactions between the growing
neoplasms and the immune effector cells using two well characterized
mammary tumor systems. These tumors, which are syngeneic to BALB/c
mice, allow the study of the effects of exogenous mammary tumor virus
(MMTV) and its superantigen properties, and of other neoantigens
appearing on mammary tumor cells of either viral etiology or chemically
induced. We will specifically focus on the alterations observed in the
lymphocytic compartment of these tumor bearing mice that have been
detected in our ongoing studies. Specifically, we will (1) elucidate
the molecular causes of the constitutive production of TNF-alpha by B
cells from tumor bearing mice and the biological significance to the
host of the overexpression of this pleiotropic cytokine; (2) we will
investigate the role that MMTV plays in the downregulation of immune
responses that occur during mammary tumor progression; (3) determine the
mechanisms underlying the thymic involution observed in mammary tumor
bearing mice; and (4) analyze the reasons for the altered cytokine
expression in peripheral T cells from tumor bearing mice. An
understanding of the causes for the immune deviations occurring during
mammary tumorigenesis at the cellular and molecular levels, will help
devise rational new therapeutic approaches for the eventual control of
breast cancer.
StatusFinished
Effective start/end date4/1/796/30/09

Funding

  • National Institutes of Health
  • National Institutes of Health: $280,268.00
  • National Institutes of Health
  • National Institutes of Health: $241,267.00
  • National Institutes of Health: $50,193.00
  • National Institutes of Health
  • National Institutes of Health: $253,544.00
  • National Institutes of Health: $284,182.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $98,033.00
  • National Institutes of Health: $92,631.00
  • National Institutes of Health: $306,788.00
  • National Institutes of Health: $92,379.00
  • National Institutes of Health: $299,578.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $23,802.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $306,788.00
  • National Institutes of Health: $105,985.00
  • National Institutes of Health: $75,750.00
  • National Institutes of Health: $50,023.00
  • National Institutes of Health: $84,840.00
  • National Institutes of Health: $88,178.00
  • National Institutes of Health: $264,179.00
  • National Institutes of Health: $273,252.00
  • National Institutes of Health: $288,674.00
  • National Institutes of Health: $84,840.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $272,102.00
  • National Institutes of Health: $215,711.00
  • National Institutes of Health: $81,418.00
  • National Institutes of Health: $290,891.00
  • National Institutes of Health

Fingerprint

Cellular Immunity
Breast Neoplasms
Neoplasms
Mouse mammary tumor virus
Oncogenic Viruses
T-Lymphocytes
Carcinogenesis
Breast
Down-Regulation
Lymphocytes
Cytokines
Matrix Metalloproteinase 9
Thymocytes
Immune System
9,10-Dimethyl-1,2-benzanthracene
Superantigens
Antigens

ASJC

  • Medicine(all)