Bone Marrow Stem Cells and the Microenvironment of Chronic Wounds

Project: Research project

Description

DESCRIPTION (provided by applicant): Chronic wounds represent a significant morbidity to the elderly and are a substantial financial burden to health care for the elderly. Several advances have been made however many patients still present with unresponsive lower extremity ulcers. The emerging field of stem cell biology may open new avenues for treatment for chronic wounds as well as a variety of other disorders. There is growing evidence that stem cells from one organ can make tissues of another organ. Our preliminary experiments indicate that some bone marrow cells can incorporate and regenerate wounded skin tissues. In a clinical protocol we have been able to heal recalcitrant wound with the application of bone marrow aspirate and cultured bone marrow stem cells. This application will address improving on our preliminary findings and identifying those bone marrow cells that are important in contributing to wound healing.
StatusFinished
Effective start/end date5/15/072/28/13

Funding

  • National Institutes of Health: $350,550.00
  • National Institutes of Health: $307,377.00
  • National Institutes of Health: $292,496.00
  • National Institutes of Health: $307,377.00
  • National Institutes of Health: $304,303.00

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Stem Cell Niche
Bone Marrow Cells
Stem Cells
Wounds and Injuries
Clinical Protocols
Wound Healing
Ulcer
Cell Biology
Lower Extremity
Cultured Cells
Bone Marrow
Morbidity
Delivery of Health Care
Skin
Therapeutics

ASJC

  • Medicine(all)