BIOCHEMISTRY OF NERVE REGENERATION

  • Wilson, David L., (PI)

Project: Research project

Description

The functions of and changes in proteins occuring in regenerating nerves
will be examined. Proteins in regenerating axons and sprouts will be
labeled in cell bodies and, after slow and fast axonal transport, will be
analyzed upon arrival at terminals. The lifetimes, modifications and
processing of such proteins will be examined in both synaptic terminals and
regenerating axons by two dimensional gel electrophoresis. Neurons from
fish and frogs will be studied. The modifications in membrane proteins and
states of polymerization of cytoskeletal proteins during regeneration will
be described. Changes in protein synthesis in glial cells during nerve
degeneration and regeneration also will be analyzed. We will be testing
hypothesis for analyzing the failure of most central nervous system neurons
to regenerate. We hope to identify the sequence of biochemical events
underlying the reorganization of damaged nerves for regeneration.
StatusFinished
Effective start/end date1/1/8312/31/86

Funding

  • National Institutes of Health

Fingerprint

Nerve Regeneration
Biochemistry
Axons
Regeneration
Proteins
Axonal Transport
Cytoskeletal Proteins
Electrophoresis, Gel, Two-Dimensional
Presynaptic Terminals
Neuroglia
Polymerization
Anura
Membrane Proteins
Central Nervous System
Neurons

ASJC

  • Medicine(all)
  • Neuroscience(all)