Bi-functional fusion proteins to regulate autoimmunity

Project: Research project

Project Details


Boosting immune regulation by increasing Tregs represents a new tactic to control autoimmunity. Current pre-
clinical and clinical studies show promise, but also some limitations of this monotherapy. The simultaneous
application of IL-2 and a distinctive immune regulating activity in a long-acting fusion protein has the potential
to improve control of autoimmunity by increasing Tregs through the associated IL-2 activity and independently
enhancing immune regulation through the associated activity. This type of therapy could be easily delivered to
large numbers of patients. This proposal will help to determine the potential of this novel fusion protein as a
new therapy for patients with autoimmune disease.
Effective start/end date11/17/2110/31/22


  • National Institute of Allergy and Infectious Diseases: $230,250.00


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