BEHAVIORAL MANAGEMENT AND STRESS RESPONSES IN HIV-1

Project: Research project

Project Details

Description

The objective of this 5 yr program project is to extend findings of our
previous NIMH supported studies of responses to psychological stressors
and their attenuation by behavioral interventions in HIV-1+ gay men. Our
previous research documented that changes in affect, endocrine and/or
immune function occur in response to psychological stressors such as
anticipation or actual diagnosis of HIV status and that responses to
diagnosis in HIV+ men can be attenuated by aerobic exercise of cognitive
behavioral stress management (CBSM). Project 1 would analyze
cardiovascular, endocrine and immunologic reactivity and recovery from
acute stressors by: (a) moving our focus from correlational field
observations to controlled laboratory manipulation; and (b) extending our
previous observations on HIV- and asymptomatic HIV+ White-American gay
men to African- and Hispanic-Americans, to symptomatic HIV-1 infected but
pre-AIDS (WHO Stage 3B) individuals and to women. Thus, the project
would examine autonomic, neuroendocrine and immune responses to an
evaluative speech stressor in 306 subjects using a 3 (ethnicity) x 2
(gender) x 3 (HIV status) design. Project 2 would also extend our
previous research by examining the effects of a 10 week CBSM group
intervention and 6 month post-maintenance program on 100 Hispanic- and
100 nonHispanic White-American WHO Stage 3B gay men randomized into the
CBSM intervention condition or an assessment only control condition. The
CBSM intervention is designed to enhance psychological adjustments to
symptomatic HIV-1 infection and reduce sexual risk and substance use
behaviors by teaching anxiety reduction and self-management techniques,
enhancing interpersonal coping skills and increasing social support. The
maintenance program combines group support and reinforcement of treatment
adherence by using well-documented relapse prevention strategies.
Psychological, endocrine and immune measures would be assessed at study
entry, immediately after the 10 wk intervention period, and after a 6
month maintenance period. Project 3 would extend our previous research
in which we found that moderate aerobic exercise prior to HIV-1 diagnosis
lowered self-report levels of distress following news of seropositivity.
The proposed project would extend our research conducted on asymptomatic
HIV+ gay White men to WHO Stage 3B African- and nonHispanic White-
American men and women coping with HIV-1 related symptoms and stressors.
Relapse prevention strategies will be used to assess feasibility of
aerobic exercise as a long-term intervention in symptomatic HIV-1
infection. The project would randomize 176 men (88 African-American, 88
nonHispanic White-American) and 88 women to either the intervention
condition or an assessment-only control condition and would conduct
aerobic fitness, psychosocial, endocrine and immune assessments at study
entry as well as 3- and 12-months post entry. Cross-project analyses
will be conducted on psychosocial, psychiatric, endocrine and immune
data.
StatusFinished
Effective start/end date2/1/9312/31/04

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,405,290.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $128,649.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $3,046,633.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $2,649,825.00
  • National Institutes of Health: $1,308,128.00
  • National Institutes of Health
  • National Institutes of Health: $2,672,234.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $2,661,610.00
  • National Institutes of Health: $49,941.00
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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