Project: Research project

Project Details


Malaria is a growing public health problem. Many countries in the
Caribbean region that launched successful malaria eradication programs
in the 1950s and 1960s are now experiencing sporadic outbreaks of
falciparum an vivax malaria. These countries remain receptive to malaria
due to their indigenous Anopheles mosquitoes. Currently, it is
impossible to predict the potential for malaria re-introductions and
epidemics because there is only limited, recent information on the status
of anopheline mosquito populations and ecologic factors affecting site-
specific receptivity for malaria parasite transmission. This proposal
seeks to investigate how Anopheles mosquito species in Trinidad differ
in their innate vector competence and natural potentials for parasite
transmission The situation in Trinidad provides a good example of how
malaria-free countries must now re-establish malaria surveillance and
control operations in response to sporadic malaria outbreaks generated
by an increasing number of imported malaria cases, including drug-
resistant Plasmodium falciparum strains, from diverse areas of the world. Species of Anopheles mosquitoes indigenous to Trinidad will be
experimentally infected with in vitro cultured gametocytes of P.
falciparum, the most pathogenic human malaria. Parameters of parasite
development for each anopheline species, determined by quantifying each
major sporogonic stage over 20 days, will be related to infections in a
reference species included in each experiment. Corresponding profiles
of vector blood-feeding behavior and digestive physiology will be
developed for each anopheline species. These studies will define
Anopheles species differences in susceptibility and parasite development.
Associated field studies will examine key aspects of vectorial capacity
for natural populations of competent vector species to identify areas of
Trinidad which are receptive to malaria re-introductions and potential
epidemics. These collaborative studies on malaria vectors in Trinidad
will provide opportunities for exploring how basic information on vector-
malaria parasite relationships can be applied to strengthen malaria
surveillance and control operations in the Caribbean region.
Effective start/end date7/1/936/30/97


  • National Institutes of Health: $25,200.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $23,975.00


  • Medicine(all)


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