Analyzing the expression and activation of Perforin-2 -a bactericidal pore-forming protein- with single domain antibodies

The phagocytosis and destruction of microorganisms is an essential function of phagocytes that protects us from invading pathogens. This application will further our understanding of this process through the development of antibodies to track and probe the conformational states of a pore-forming protein, Perforin-2, that underpins this critical protective function.