Analyzing the expression and activation of Perforin-2 -a bactericidal pore-forming protein- with single domain antibodies

Project: Research project

Project Details

Description

The phagocytosis and destruction of microorganisms is an essential function of phagocytes that protects us from invading pathogens. This application will further our understanding of this process through the development of antibodies to track and probe the conformational states of a pore-forming protein, Perforin-2, that underpins this critical protective function.
StatusActive
Effective start/end date12/17/2011/30/22

Funding

  • National Institute of Allergy and Infectious Diseases: $191,875.00

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.