ALZHEIMER'S DISEASE--A MULTIDISCIPLINARY APPROACH

  • Jope, Richard S (PI)
  • Casey, Michael (PI)
  • Folks, David (PI)
  • Powers, Richard (PI)
  • Leli, Dano (PI)
  • Harrell, Lindy (PI)
  • Binder, Lester (PI)
  • Harrell, Lindy (PI)
  • Garner, Craig (PI)
  • Wyss, J. Michael (PI)
  • Haley, William (PI)
  • Johnson, Gail (PI)

Project: Research project

Description

This Program Project is a multidisciplinary effort dedicated to
the study of Alzheimer's Disease (AD) and related disorders. It is
built upon established investigative talents. This Project will
consist of two components: A Clinical Core and Individual
Research Projects. This Core will be dedicated to the
recruitment and longitudinal assessment (1-year intervals) of 150-
175 demented, 50-60 depressed and 50-60 normal elderly
individuals. They will receive extensive clinical and demographic
assessment, neuropsychological, neurophysiological (spectral
analysis EEG, computerized brain electrical activity mapping,
cognitive and somatosensory evoked potentials), and
neuroradiological (MRI) evaluations. Provision for
neuropathological examination will be incorporated and all data
analysis performed through this unit. Individual Research Projects will encompass many of the clinical,
social and biological issues of dementing illness. They will
interrelate through intellectual goals and the core patient
population. These interactions will be further enhanced by the
use of common patient data sets for all statistical analyses.
Projects 1 and 2 will explore alternative methods for making a
diagnosis and prognosis in AD by investigating peripheral
cholinergic markers and activated regional cereberal blood flow.
Project 3 will examine theraputic issues by investigating the
usefulness of chronic oral physostigmine administration in AD.
Project 4 will investigate basic biological mechanism, by
exploring the role of tau, a protein associated with the paired-
helical filament, in A.D. Finally, Project 5 will delve into social
issues by exploring caregiver problems. The approach as outlined will provide an active interaction
among investigators and thereby potentiate the likelihood that
valuable new information on the neurobiological mechanisms of
Alzheimer's Disease and related disorders will be acquired.
StatusFinished
Effective start/end date8/1/874/30/02

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Alzheimer Disease
Choline
Phosphatidylinositols
Glucocorticoids
Signal Transduction
Cholinergic Agents
GTP-Binding Proteins
Membranes
Hydrolysis
Second Messenger Systems
Brain
Protein Kinase C
Physostigmine
Phospholipase D
Erythrocytes
Cholinergic Neurons
Acetylcholine
Type C Phospholipases
Pseudocholinesterase
Hormones

ASJC

  • Medicine(all)