ALZHEIMER DISEASE &AGING--BRAIN REACTIVE ANTIBODIES

Project: Research project

Description

Brain reactive antibodies (BRAs) have been identified in the blood
of a majority of patients with Alzheimer's disease (AD).
However, the role of these antibodies in the pathogenesis of the
disease is unknown. Preliminary research from our laboratory
suggests that BRAs occurs more frequently in AD patients than
normal controls and that these antibodies have a different pattern
of activity between patients with Alzheimer's disease and that of
adult patients with Down's syndrome. These data may also have
implication for the development of possible subtypes of AD. This
application proposes to test a number of hypotheses for
establishing the specificity, activity, and function(s) of BRAs in
Alzheimer's disease. Sera from 240 patients with Alzheimer's
disease, 90 patients with multi-infarct dementia, (age 60 or
older), 90 elderly normal subjects, and 30 patients with Down
syndrome, 35 years or older, will be analyzed for the occurrence,
quantification, and consequently, that neuronal cell loss in
Alzheimer's disease may be mediated by antibodies. Samples of
brain obtained at autopsy of Alzheimer's cases will be eluded for
determining the occurrence of brain-bound antibodies.
Electroblots prepared from spinal cord, samples of brain and
specific proteins isolated from brain will be used for testing the
antigenic specificity of BRAs and the value of BRAs as markers in
identifying possible subtypes of AD. Data will also be generated to examine the hypotheses a) that the
occurrence of BRAs is related to the duration, age of onset, and
family history of dementia; and b) that the pattern of cognitive
loss determined using a battery of information processings is
related to the presence of circulating BRAs.
StatusFinished
Effective start/end date8/1/877/31/90

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

Fingerprint

Alzheimer Disease
Antibodies
Brain
Multi-Infarct Dementia
Down Syndrome
Automatic Data Processing
Age of Onset
Dementia
Autopsy
Spinal Cord
Serum
Research

ASJC

  • Medicine(all)