ADJUSTMENT TO BREAST CANCER AMONG YOUNGER WOMEN

Project: Research project

Description

This research concerns quality of life among younger women
(premenopausal) diagnosed with, and treated for, early stage breast
cancer. There is evidence that breast cancer leads to more distress
among younger than older patients, and many possible reasons have been
suggested for this difference. Study 1 (descriptive study) will examine
this issue, assessing the levels of concerns expressed by younger breast
cancer patients with regard to a range of issues suggested by various
sources as important. We will also assess factors that we view as
vulnerability/resilience variables (personality qualities of optimism and
investment in body image as a source of self-esteem, contextual qualities
of social support/social integration), to determine how the latter
variables render individuals vulnerable to higher levels of various
concerns. Finally, we will assess mediating variables (coping,
perceptions of partner reactions to the surgery) and levels of quality
of life (affective, social, and psychosexual disturbance) to determine
the extent to which the concerns reported are linked to the distress and
dysfunction that are the ultimate outcomes of interest, and to examine
the role of coping differences as pathways in this chain. We will also
collect open-ended data to ensure that we have identified all meaningful
sources of concern among these patients. Subjects will be equivalently
represented on extent of surgery (mastectomy vs lumpectomy), and 3
periods of time since surgery (3, 6, and 12 months). We will also
recruit as close to equal numbers as we can from the 3 ethnic groups
represented in large numbers in this population (Black, non-Hispanic
White, and Hispanic). Study 2 (in a new sample) will implement and test the effectiveness of
an intervention designed to meet the special needs and concerns of
younger breast cancer patients. This intervention is based on findings
from the literature of breast cancer, on previous intervention studies
of breast cancer patients, on the experiences of this research team in
intervention research using other populations, and on the results of
Study 1. The once-a-week, 10-week intervention will target participants'
sense of confidence about remaining cancer free, their coping responses
(increasing acceptance and reframing of the experience, and decreasing
avoidance coping), their utilization of social support, and their self-
image, in a group-therapy format. The control group will be an
education/standard of care group, in which subjects learn of the benefits
of implementing some of the changes as described above in their
orientation, but will not undergo the group experience in solidifying and
acting on this information. Treatment efficacy will be assessed at 3,
6, and 12 months post-surgery, in terms of all the quality-of-life
outcome variables listed above. This study will also have the benefit
of addressing the generality of the treatment effects across
ethnic/cultural boundaries.
StatusFinished
Effective start/end date9/30/942/28/12

Funding

  • National Institutes of Health: $472,337.00
  • National Institutes of Health: $307,219.00
  • National Institutes of Health: $485,104.00
  • National Institutes of Health: $442,900.00
  • National Institutes of Health: $472,732.00
  • National Institutes of Health
  • National Institutes of Health: $463,077.00
  • National Institutes of Health: $29,358.00
  • National Institutes of Health: $444,776.00
  • National Institutes of Health: $497,845.00
  • National Institutes of Health: $393,484.00
  • National Institutes of Health
  • National Institutes of Health: $28,636.00
  • National Institutes of Health: $30,102.00
  • National Institutes of Health
  • National Institutes of Health: $449,588.00
  • National Institutes of Health: $12,429.00
  • National Institutes of Health
  • National Institutes of Health

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Breast Neoplasms
Social Adjustment
Fatigue
Interleukin-2
Hispanic Americans
Sleep
Quality of Life
Group Psychotherapy
Recurrence
Lymphocyte Subsets
Growth
Social Support
Cytokines
Neoplasms
Natural Killer Cells
Interferon-gamma
Control Groups
Hydrocortisone
Physiological Adaptation
Therapeutics

ASJC

  • Medicine(all)