Project Narrative Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain and mutations in HCN channels are linked to heart arrhythmia and epilepsy. We will here measure conformational changes in HCN channels to understand how HCN channels are activated by hyperpolarization. A better understanding of HCN channel will aid in development of better anti-arrhythmic and anti-epileptic drugs targeting HCN channels.
|Effective start/end date||7/1/20 → 4/30/22|
- National Institute of General Medical Sciences: $748,017.00
- National Institute of General Medical Sciences: $380,696.00
- National Institute of General Medical Sciences: $330,586.00
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.