Activation mechanism in HCN channels.

Project: Research project

Project Details

Description

Project Narrative Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain and mutations in HCN channels are linked to heart arrhythmia and epilepsy. We will here measure conformational changes in HCN channels to understand how HCN channels are activated by hyperpolarization. A better understanding of HCN channel will aid in development of better anti-arrhythmic and anti-epileptic drugs targeting HCN channels.
StatusFinished
Effective start/end date7/1/204/30/22

Funding

  • National Institute of General Medical Sciences: $748,017.00
  • National Institute of General Medical Sciences: $380,696.00
  • National Institute of General Medical Sciences: $330,586.00

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