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  Closed loop control of vibration for muscle spasms after human spinal cord injury: efficacy and mechanism

  Perez, M.

  National Institutes of Health

  2/15/18 → 12/31/22

  Project: Research project

  • Vibration
  • Spasm
  • Spinal Cord Injuries
  • Wearable Electronic Devices
  • Achilles Tendon

• Molecular Genetics of Synaptic Plasticity

  Bianchi, L.

  National Institutes of Health

  2/1/18 → 1/31/23

  Project: Research project

  • Neuronal Plasticity
  • GABAergic Neurons
  • Molecular Biology
  • Drive
  • Cations

• The Role of Osteopontin-OGDHL Axis in HFpEF

  Shehadeh, L.

  National Institutes of Health

  2/1/18 → 1/31/22

  Project: Research project

  • Ketoglutarate Dehydrogenase Complex
  • Osteopontin
  • Heart Failure
  • Preliminary Data
  • Phenotype

• NOVEL INNATE MECHANISMS OF IMMUNE TOLERANCE INDUCTION IN ALLOGENEIC HCT FOR HEMOGLOBINOPATHIES

  Pillai, A.

  National Institutes of Health

  1/1/18 → 12/31/21

  Project: Research project

  • Hemoglobinopathies
  • Immune Tolerance
  • Cell Transplantation
  • Myeloid Cells
  • Lymphatic Irradiation

• Inflammatory signaling in depression regulated by Toll-like receptors 2 and 4

  Jope, R. S.

  National Institutes of Health

  1/1/18 → 12/31/21

  Project: Research project

  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Depression
  • Antidepressive Agents
  • Mouse Tlr2 protein

• Epigenetic Targeting of Afro-Caribbean Variant of HTLV-1 Related Adult T-cell Leukemia-lymphoma

  Carlos Ramos, J.

  National Institutes of Health

  1/1/18 → 12/31/22

  Project: Research project

  • Adult T Cell Leukemia Lymphoma
  • Human T-lymphotropic virus 1
  • belinostat
  • Epigenomics
  • Histone Deacetylases

• A Novel Drug Target for Aggressive Prostate Cancer

  Burnstein, K. L.

  National Institutes of Health

  1/1/18 → 12/31/21

  Project: Research project

  • Vasopressin Receptors
  • Castration
  • Prostatic Neoplasms
  • relcovaptan
  • Androgen Receptors

• Illuminating the Druggable Genome Resource Dissemination and Outreach Center (IDG-RDOC)

  Schuerer, S. C.

  National Institutes of Health

  12/1/17 → 11/30/23

  Project: Research project

  • outreach
  • genome
  • Genome
  • engineering
  • Lighting

• Low dose IL-2 and human regulatory T cells

  Malek, T.

  National Institutes of Health

  11/21/17 → 11/30/22

  Project: Research project

  • Regulatory T-Lymphocytes
  • Interleukin-2
  • Autoimmune Diseases
  • Eragrostis
  • Autoimmunity

• Role of ryanodine receptor dysfunction after spinal cord injury

  Bramlett, H.

  National Institutes of Health

  10/1/17 → 9/30/21

  Project: Research project

  • Ryanodine Receptor Calcium Release Channel
  • Spinal Cord Injuries
  • NADH oxidase
  • Muscles
  • Contusions

• Whole Genome Sequencing in Ethnically Diverse Cohorts for the ADSP Follow-Up Study (FUS)

  Pericak-Vance, M. A.

  National Institutes of Health

  9/30/17 → 8/31/22

  Project: Research project

  • Whole Genome Sequencing
  • Hispanic Americans
  • African Americans
  • Datasets
  • Quality Control

• Enhancer RNA Therapy

  Shiekhattar, R.

  National Institutes of Health

  9/30/17 → 7/31/22

  Project: Research project

  • RNA
  • Mutation
  • Neoplasms
  • MAP Kinase Signaling System
  • Neoplasm Genes

• A Randomized, Blinded, Placebo-Controlled Clinical Trial to Evaluate Longeveron Mesenchymal Stem Cell (LMSC) Therapy for Treating The Metabolic Syndrome

  Hare, J.

  National Institutes of Health

  9/30/17 → 3/31/21

  Project: Research project

  • Controlled Clinical Trials
  • Cell- and Tissue-Based Therapy
  • Metabolic Syndrome
  • Mesenchymal Stem Cells
  • Placebos

• A Multi-site Multi-Setting RCT of Integrated HIV Prevention and HCV Care for PWID

  Feaster, D. J.

  National Institutes of Health

  9/30/17 → 7/31/22

  Project: Research project

  • Pre-Exposure Prophylaxis
  • HIV
  • Patient Navigation
  • Pharmaceutical Preparations
  • Needle-Exchange Programs

• Disparities in Transition of Care after Acute Stroke Hospitalization: The Transition of Care Stroke Disparity Study (TCSD-S)

  Romano, J. G., Rundek, T. & Sacco, R. L.

  National Institutes of Health

  9/26/17 → 6/30/22

  Project: Research project

  • Patient Transfer
  • Hospitalization
  • Stroke
  • Social Determinants of Health
  • Patient Readmission

• 1/13 ApoL1 Genotypes in Kidney Donors and Long-Term Outcomes in Kidney Transplant Recipients Clinical Center

  Fornoni, A.

  National Institutes of Health

  9/25/17 → 5/31/22

  Project: Research project

  • Transplant Recipients
  • Tissue Donors
  • Genotype
  • Puerto Rico
  • Kidney

• Aptamer chimeras for the in vivo modulation of beta cell mass and immunogenicity

  Abdulreda, M. H.

  National Institutes of Health

  9/20/17 → 8/31/21

  Project: Research project

  • Nucleotide Aptamers
  • RNA
  • Apoptosis
  • Homeostasis
  • Islets of Langerhans

• UM CFAR SCCC Argentina Consortium for research and training in Virally Induced AIDS Malignancies

  Mesri, E. A.

  National Institutes of Health

  9/20/17 → 8/31/22

  Project: Research project

  • Argentina
  • Acquired Immunodeficiency Syndrome
  • AIDS
  • leadership
  • leader

• Protective Genetic Variants for Alzheimer Disease in the Amish

  Scott, W. K. & Pericak-Vance, M. A.

  National Institutes of Health

  9/15/17 → 6/30/22

  Project: Research project

  • Amish
  • Alzheimer Disease
  • Whole Genome Sequencing
  • Alzheimer disease type 2
  • Inbreeding

• A Multifaceted Approach to Study Tissue and Cell Type Specific Molecular Mechanisms of the Host Response to Acute/Chronic Viral Infection

  Thomas, E.

  National Institutes of Health

  9/10/17 → 8/31/22

  Project: Research project

  • Innate Immunity
  • Virus Diseases
  • interferon type III
  • Epithelial Cells
  • Fat Body

• NextGen Random Forests

  Ishwaran, H.

  National Institutes of Health

  9/1/17 → 5/31/21

  Project: Research project

  • Big data
  • Scalability
  • Machine learning
  • Tumors
  • Software packages

• Cardiac Toxicity in Perinatally HIV-infected Adolescents and Young Adults, a Longitudinal Study

  Lipshultz, S. E.

  National Institutes of Health

  9/1/17 → 5/31/21

  Project: Research project

  • Cardiotoxicity
  • Longitudinal Studies
  • Young Adult
  • HIV
  • Highly Active Antiretroviral Therapy

• Low-dose IL-2 in Established T1D

  Malek, T., Skyler, J. S. & Pugliese, A.

  National Institutes of Health

  8/15/17 → 7/31/23

  Project: Research project

  • Type 1 Diabetes Mellitus
  • Interleukin-2
  • Regulatory T-Lymphocytes
  • Insulin Secretion
  • Safety

• A Novel Role for cMyc in Vascular Homeostasis

  Rodrigues, C. D.

  National Institutes of Health

  8/10/17 → 7/31/21

  Project: Research project

  • Homeostasis
  • Inflammation
  • Blood Vessels
  • Endothelial Cells
  • Cardiovascular Diseases

• Retroviral Replicating Vector-mediated Gene Therapy for Ovarian Cancer

  Kasahara, N.

  National Institutes of Health

  8/1/17 → 7/31/22

  Project: Research project

  • Genetic Therapy
  • Ovarian Neoplasms
  • Cause of Death
  • Survival
  • Neoplasms

• Microbiome Meta-Analysis Platform

  Kabuka, M. R.

  National Institutes of Health

  8/1/17 → 8/31/21

  Project: Research project

  • meta-analysis
  • containerization
  • bioinformatics
  • convention
  • pressing

• Unifying Templates, Ontologies and Tools to Achieve Effective Annotation of Bioassay Protocols

  Schuerer, S. C.

  National Institutes of Health

  8/1/17 → 7/31/21

  Project: Research project

  • Bioassay
  • Assays
  • Ontology
  • Network protocols
  • Data structures

• Therapeutic efficacy of Pirfenidone in Pancreatitis

  Dudeja, V.

  National Institutes of Health

  7/20/17 → 3/31/22

  Project: Research project

  • pirfenidone
  • Pancreatitis
  • Chronic Pancreatitis
  • Inflammation
  • Pancreas

• Role of reservoir composition and T cell immunity in HIV rebound kinetics

  Stevenson, M.

  National Institutes of Health

  7/19/17 → 6/30/22

  Project: Research project

  • Viremia
  • HIV
  • Viruses
  • Macaca
  • Vaccination

• Anti-inflammatory therapy to augment CFTR rescue in CF patients

  Salathe, M. A.

  National Institutes of Health

  7/18/17 → 5/31/21

  Project: Research project

  • Cystic Fibrosis
  • Losartan
  • Anti-Inflammatory Agents
  • Chloride Channels
  • Angiotensin Receptor Antagonists

• Microbial Dysbiosis and TLR2 Activation Contribute to Immune Activation, Inflammation and HIV Persistence in the Context of Opioid Abuse Despite ART Therapy

  Roy, S.

  National Institutes of Health

  7/1/17 → 5/31/22

  Project: Research project

  • Dysbiosis
  • Opioid-Related Disorders
  • HIV
  • Inflammation
  • Disease Progression

• Prevention of HIV and drug abuse-induced brain pathology by targeting mitochondria

  Toborek, M. J.

  National Institutes of Health

  7/1/17 → 5/31/22

  Project: Research project

  • Methamphetamine
  • Substance-Related Disorders
  • Mitochondria
  • HIV
  • Pathology

• Medical Scientist Training Program

  Lemmon, S.

  National Institutes of Health

  7/1/17 → 6/30/22

  Project: Research project

  • training program
  • student
  • Schools of medicine
  • biomedical research
  • medicine

• Targeting Multiple Kinases to Treat Experimental Spinal Cord Injury

  Lemmon, V. & Bixby, J.

  National Institutes of Health

  7/1/17 → 4/30/22

  Project: Research project

  • Spinal Cord Injuries
  • Phosphotransferases
  • Axons
  • Pyramidal Tracts
  • Neuronal Outgrowth

• A Binational Study to Understand Dementia Risk and Disparities of Mexican Americans: The Role of Migration and Social Determinants

  Zeki Al Hazzouri, A.

  National Institutes of Health

  6/15/17 → 5/31/21

  Project: Research project

  • determinants
  • migration
  • Mexico
  • health
  • social position

• Modulating microglial phenotype to prevent SCI-induced central neuropathic pain

  Ghosh, M.

  National Institutes of Health

  6/1/17 → 5/31/21

  Project: Research project

  • Neuralgia
  • Spinal Cord Injuries
  • Phenotype
  • Microglia
  • Macrophages

• Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment

  Zeki Al Hazzouri, A.

  National Institutes of Health

  5/1/17 → 4/30/21

  Project: Research project

  • Dementia
  • Risk Assessment
  • Alzheimer Disease
  • Heart
  • Brain

• Innate Immune Activation in Autoimmune Myopathy

  Ascherman, D.

  National Institutes of Health

  4/10/17 → 3/31/22

  Project: Research project

  • Histidine-tRNA Ligase
  • Myositis
  • Muscular Diseases
  • Muscles
  • Muscle Weakness

• Intravenous MitoTargeted AAV9 Gene Therapy for Treatment of Visual Loss and Encephalopathy in Leigh Syndrome and NARP

  Guy, J.

  National Institutes of Health

  4/1/17 → 3/31/21

  Project: Research project

  • Maternally Inherited Leigh Syndrome
  • Leigh Disease
  • Brain Diseases
  • Genetic Therapy
  • Mitochondrial DNA

• Mechanisms of optic nerve regeneration

  Hackam, A. S.

  National Institutes of Health

  4/1/17 → 3/31/22

  Project: Research project

  • Nerve Regeneration
  • Retinal Ganglion Cells
  • Optic Nerve
  • Regeneration
  • Optic Nerve Injuries

• Harnessing Innervation to Promote Pancreatic Islet Function

  Caicedo-Vierkant, D. A.

  National Institutes of Health

  4/1/17 → 3/31/21

  Project: Research project

  • Islets of Langerhans
  • Insulin Secretion
  • Autonomic Pathways
  • Transplants
  • Capillary Permeability

• Integrated Behavioral Activation and HIV Risk Reduction Counseling for MSM with Stimulant Abuse

  Safren, S.

  National Institutes of Health

  4/1/17 → 1/31/22

  Project: Research project

  • N-nitrosoiminodiacetic acid
  • Anhedonia
  • Unsafe Sex
  • Risk Reduction Behavior
  • Sexual Behavior

• Nitric Oxide and sex differences in cardiac repair

  Hare, J.

  National Institutes of Health

  3/17/17 → 2/28/21

  Project: Research project

  • Oxidation-Reduction
  • Sex Characteristics
  • Oxidoreductases
  • Nitric Oxide
  • Reactive Oxygen Species

• The microbiota, a possible link between Th17 cells and depression

  Beurel, E.

  National Institutes of Health

  3/15/17 → 1/31/22

  Project: Research project

  • Th17 Cells
  • Microbiota
  • Depression
  • Quorum Sensing
  • Bacteria

• Mechanistic Links Between Changing Estrogen Profiles, Inflammation and the Increased Risk and Metastasis of Breast Cancer in Obese Women

  Slingerland, J. M.

  National Institutes of Health

  3/7/17 → 2/28/22

  Project: Research project

  • Estrone
  • Estrogens
  • Estradiol
  • Breast Neoplasms
  • Neoplasm Metastasis

• Role of Microbial dysbiosis and altered metabolomics in the context of Opioid abuse and ART in HIV disease progression

  Roy, S.

  National Institutes of Health

  3/1/17 → 1/31/22

  Project: Research project

  • Dysbiosis
  • Opioid-Related Disorders
  • Metabolomics
  • Disease Progression
  • HIV

• Mechanisms of toll-like receptor-mediated neurotoxicity in the ischemic retina

  Ivanov, D. V.

  National Institutes of Health

  3/1/17 → 2/28/21

  Project: Research project

  • Toll-Like Receptors
  • Retina
  • Retinal Ganglion Cells
  • Ischemia
  • Neuroglia

• Stabilizing the tripartite synaptic complex following TBI

  Sick, T. & Liebl, D. J.

  National Institutes of Health

  2/1/17 → 12/31/21

  Project: Research project

  • Traumatic Brain Injury
  • Serine
  • Astrocytes
  • Wounds and Injuries
  • Neurons

• Targeting novel pathways to enhance gastrointestinal integrity during HIV infection

  Klatt, N.

  National Institutes of Health

  2/1/17 → 1/31/22

  Project: Research project

  • HIV Infections
  • Neutrophils
  • Dysbiosis
  • Proteome
  • HIV

• Role of TRF2 in DNA recombination

  Verdun, R. E.

  National Institutes of Health

  2/1/17 → 1/31/22

  Project: Research project

  • AICDA (activation-induced cytidine deaminase)
  • Genetic Recombination
  • DNA Repair
  • DNA
  • DNA Breaks