Zhibin Chen

Associate Professor

  • 3263 Citations
20002023
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Research Output 2000 2018

  • 3263 Citations
  • 34 Article
  • 1 Review article
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Article
2018
3 Citations (Scopus)

Identification of a gene-expression predictor for diagnosis and personalized stratification of lupus patients

Ding, Y., Li, H., He, X., Liao, W., Yi, Z., Yi, J., Chen, Z., Moore, D. J., Yi, Y. & Xiang, W., Jul 1 2018, In : PLoS One. 13, 7, e0198325.

Research output: Contribution to journalArticle

lupus erythematosus
Gene expression
Systemic Lupus Erythematosus
Gene Expression
gene expression
1 Citation (Scopus)

Identification of epigenetic modulators in human breast cancer by integrated analysis of DNA methylation and RNA-Seq data

Zhou, X., Chen, Z. & Cai, X., Jan 1 2018, (Accepted/In press) In : Epigenetics.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
RNA
Breast Neoplasms
Methylation
2 Citations (Scopus)

Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines

Miska, J., Lui, J. B., Toomer, K. H., Devarajan, P., Cai, X., Houghton, J. M., Lopez, D. M., Abreu, M. T., Wang, G. & Chen, Z., Mar 1 2018, In : Journal of Experimental Medicine. 215, 3, p. 841-858 18 p.

Research output: Contribution to journalArticle

Carcinogenesis
Cytokines
Inflammation
Stomach Neoplasms
Immunity
2017
6 Citations (Scopus)

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice

Dwyer, C. J., Bayer, A. L., Fotino, C., Yu, L., Cabello-Kindelan, C., Ward, N. C., Toomer, K. H., Chen, Z. & Malek, T., Dec 19 2017, In : Science Signaling. 10, 510, eaam9563.

Research output: Contribution to journalArticle

Inbred NOD Mouse
T-cells
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Medical problems
2016
28 Citations (Scopus)

Breast cancers from black women exhibit higher numbers of immunosuppressive macrophages with proliferative activity and of crown-like structures associated with lower survival compared to non-black Latinas and Caucasians

Sengul, T., Santander, A. M., Miao, F., Sanchez, L. G., Jorda, M., Glück, S., Ince, T., Nadji, M., Chen, Z., Penichet, M. L., Cleary, M. P. & Torroella-Kouri, M., Jul 1 2016, In : Breast Cancer Research and Treatment. 158, 1, p. 113-126 14 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Crowns
Hispanic Americans
Macrophages
Breast Neoplasms
4 Citations (Scopus)

Gut microbiota amplifies host-intrinsic conversion from the CD8 T cell lineage to CD4 T cells for induction of mucosal immune tolerance

Lui, J. B., McGinn, L. S. & Chen, Z., Jan 2 2016, In : Gut Microbes. 7, 1, p. 40-47 8 p.

Research output: Contribution to journalArticle

Immune Tolerance
Cell Lineage
T-Lymphocytes
Microbiota
Large Intestine
2015

Conversion of the CD8 lineage to CD4 T cells

Guzman, M. P. & Chen, Z., 2015, In : Oncotarget. 6, 25, p. 20748-20749 2 p.

Research output: Contribution to journalArticle

CD8-Positive T-Lymphocytes
CD4-Positive T-Lymphocytes
Immune Tolerance
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
8 Citations (Scopus)

Cross-differentiation from the CD8 lineage to CD4T cells in the gut-associated microenvironment with a nonessential role of microbiota

Lui, J. B., Devarajan, P., Teplicki, S. A. & Chen, Z., Feb 3 2015, In : Cell Reports. 10, 4, p. 574-585 12 p.

Research output: Contribution to journalArticle

Microbiota
Large Intestine
Regulatory T-Lymphocytes
T-cells
Plasticity
1 Citation (Scopus)

Erratum to Cross-Differentiation from the CD8 Lineage to CD4 T Cells in the Gut-Associated Microenvironment with a Nonessential Role of Microbiota [Cell Reports, 10, 4, (2015), 574-585]

Lui, J. B., Devarajan, P., Teplicki, S. A. & Chen, Z., Jun 23 2015, In : Cell Reports. 11, 11, p. 1844-1845 2 p.

Research output: Contribution to journalArticle

T-cells
10 Citations (Scopus)

Genome-wide analysis of alternative transcripts in human breast cancer

Wen, J., Toomer, K. H., Chen, Z. & Cai, X., Apr 26 2015, In : Breast Cancer Research and Treatment. 151, 2, p. 295-307 13 p.

Research output: Contribution to journalArticle

Genome
Breast Neoplasms
Transcriptome
Genes
Gene Expression Profiling
2014
28 Citations (Scopus)

Autoimmunity as a double agent in tumor killing and cancer promotion

Toomer, K. H. & Chen, Z., Jan 1 2014, In : Frontiers in Immunology. 5, MAR, Article 116.

Research output: Contribution to journalArticle

Autoimmunity
Neoplasms
Cytokines
Immunotherapy
Carcinogenesis
9 Citations (Scopus)

Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots

Leiva, A. G., Chen, A. L., Devarajan, P., Chen, Z., Damanpour, S., Hall, J. A., Bianco, A. C., Li, J., Badiavas, E. V., Zaias, J., Miteva, M., Romanelli, P., Nouri, K. & Wikramanayake, T., Jan 1 2014, In : Journal of Investigative Dermatology. 134, 7, p. 1817-1827 11 p.

Research output: Contribution to journalArticle

Myelin P0 Protein
Skin Abnormalities
Skin
Sebaceous Glands
Knockout Mice
7 Citations (Scopus)

Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue

Devarajan, P., Miska, J., Lui, J. B., Swieboda, D. & Chen, Z., Jan 1 2014, In : Journal of Immunology. 193, 9, p. 4368-4380 13 p.

Research output: Contribution to journalArticle

Autoimmunity
Type 1 Diabetes Mellitus
T-Lymphocytes
Genetic Polymorphisms
Interleukin-7
35 Citations (Scopus)

Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance

Miska, J., Abdulreda, M. H., Devarajan, P., Lui, J. B., Suzuki, J., Pileggi, A., Berggren, P. O. & Chen, Z., Mar 1 2014, In : Journal of Experimental Medicine. 211, 3, p. 441-456 16 p.

Research output: Contribution to journalArticle

Transplantation Tolerance
Cell Communication
Eragrostis
Regulatory T-Lymphocytes
T-Lymphocytes
2013
5 Citations (Scopus)

A Biophysical Model for Identifying Splicing Regulatory Elements and Their Interactions

Wen, J., Chen, Z. & Cai, X., Jan 30 2013, In : PLoS One. 8, 1, e54885.

Research output: Contribution to journalArticle

Alternative Splicing
RNA Precursors
Exons
Polypyrimidine Tract-Binding Protein
Binding Sites
36 Citations (Scopus)

Autoimmune effector memory T cells: The bad and the good

Devarajan, P. & Chen, Z., Dec 1 2013, In : Immunologic Research. 57, 1-3, p. 12-22 11 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Autoimmune Diseases
Autoantigens
Immunologic Memory
Immunomodulation
4 Citations (Scopus)

The immunological identity of tumor: Self implications

Miska, J., Devarajan, P. & Chen, Z., Apr 1 2013, In : OncoImmunology. 2, 4, e23794.

Research output: Contribution to journalArticle

Autoimmunity
Self Tolerance
Neoplasms
2012
20 Citations (Scopus)

Autoimmunity-mediated antitumor immunity: Tumor as an immunoprivileged self

Miska, J., Bas Infante, E., Devarajan, P. & Chen, Z., Oct 1 2012, In : European Journal of Immunology. 42, 10, p. 2584-2596 13 p.

Research output: Contribution to journalArticle

Eragrostis
Autoimmunity
Immunity
Regulatory T-Lymphocytes
Neoplasms
6 Citations (Scopus)
Type 1 Diabetes Mellitus
Transcriptome
Biomarkers
Homeostasis
Genes
11 Citations (Scopus)

Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes

Han, D., Cai, X., Wen, J., Matheson, D., Skyler, J. S., Kenyon, N. S. & Chen, Z., Nov 1 2012, In : Clinical and Experimental Immunology. 170, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Transcriptome
Biomarkers
CTLA-4 Antigen
Genes
2011
14 Citations (Scopus)

Induction of self-antigen-specific Foxp3+ regulatory T cells in the periphery by lymphodepletion treatment with anti-mouse thymocyte globulin in mice

Lu, Y., Suzuki, J., Guillioli, M., Umland, O. & Chen, Z., Sep 1 2011, In : Immunology. 134, 1, p. 50-59 10 p.

Research output: Contribution to journalArticle

Antilymphocyte Serum
Autoantigens
Regulatory T-Lymphocytes
Therapeutics
T-Lymphocytes
2010
24 Citations (Scopus)

Immune tolerance induction by integrating innate and adaptive immune regulators

Suzuki, J., Ricordi, C. & Chen, Z., Jun 25 2010, In : Cell Transplantation. 19, 3, p. 253-268 16 p.

Research output: Contribution to journalArticle

Immune Tolerance
Regulatory T-Lymphocytes
Cell- and Tissue-Based Therapy
Eragrostis
Peripheral Tolerance
134 Citations (Scopus)

Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells

Vendrame, F., Pileggi, A., Laughlin, E., Allende, G., Martin-Pagola, A., Molano, R., Diamantopoulos, S., Standifer, N., Geubtner, K., Falk, B. A., Ichii, H., Takahashi, H., Snowhite, I., Chen, Z., Mendez, A. J., Chen, L. J., Sageshima, J., Ruiz, P., Ciancio, G., Ricordi, C. & 4 others, Reijonen, H., Nepom, G. T., Burke, G. W. & Pugliese, A., Apr 1 2010, In : Diabetes. 59, 4, p. 947-957 11 p.

Research output: Contribution to journalArticle

Pancreas Transplantation
Type 1 Diabetes Mellitus
Autoantibodies
Kidney Transplantation
Immunosuppression
2007
50 Citations (Scopus)

Lack of Foxp3 function and expression in the thymic epithelium

Liston, A., Farr, A. G., Chen, Z., Benoist, C., Mathis, D., Manley, N. R. & Rudensky, A. Y., Mar 19 2007, In : Journal of Experimental Medicine. 204, 3, p. 475-480 6 p.

Research output: Contribution to journalArticle

Thymocytes
Epithelium
Epithelial Cells
Cell Lineage
T-Lymphocytes
2006
39 Citations (Scopus)

Modeling CTLA4-linked autoimmunity with RNA interference in mice

Chen, Z., Stockton, J., Mathis, D. & Benoist, C., Oct 31 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 44, p. 16400-16405 6 p.

Research output: Contribution to journalArticle

RNA Interference
Autoimmunity
Genomic Imprinting
Phenotype
Gene Transfer Techniques
2005
102 Citations (Scopus)

Feedback inhibition of leptin receptor/Jak2 signaling via Tyr 1138 of the leptin receptor and suppressor of cytokine signaling 3

Dunn, S. L., Björnholm, M., Bates, S. H., Chen, Z., Seifert, M. & Myers, M. G., Apr 1 2005, In : Molecular Endocrinology. 19, 4, p. 925-938 14 p.

Research output: Contribution to journalArticle

Leptin Receptors
Leptin
Cytokines
STAT3 Transcription Factor
RNA Interference
97 Citations (Scopus)

How defects in central tolerance impinge on a deficiency in regulatory T cells

Chen, Z., Benoist, C. & Mathis, D., Oct 11 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 41, p. 14735-14740 6 p.

Research output: Contribution to journalArticle

Central Tolerance
Regulatory T-Lymphocytes
Self Tolerance
Lung
Liver
441 Citations (Scopus)

The cellular mechanism of Aire control of T cell tolerance

Anderson, M. S., Venanzi, E. S., Chen, Z., Berzins, S. P., Benoist, C. & Mathis, D., Aug 1 2005, In : Immunity. 23, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

Thymocytes
T-Lymphocytes
Antigens
Central Tolerance
Epithelial Cells
224 Citations (Scopus)

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

Chen, Z., Herman, A. E., Matos, M., Mathis, D. & Benoist, C., Nov 21 2005, In : Journal of Experimental Medicine. 202, 10, p. 1387-1397 11 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Lymph Nodes
T-Lymphocytes
Microarray Analysis
T-Cell Antigen Receptor
2003
30 Citations (Scopus)

Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand

Martin-Orozco, N., Chen, Z., Poirot, L., Hyatt, E., Chen, A., Kanagawa, O., Sharpe, A., Mathis, D. & Benoist, C., Dec 15 2003, In : Journal of Immunology. 171, 12, p. 6954-6960 7 p.

Research output: Contribution to journalArticle

OX40 Ligand
T-Lymphocytes
Cell Survival
Inbred NOD Mouse
Autoantigens
2002
1629 Citations (Scopus)

Projection of an immunological self shadow within the thymus by the aire protein

Anderson, M. S., Venanzi, E. S., Klein, L., Chen, Z., Berzins, S. P., Turley, S. J., Von Boehmer, H., Bronson, R., Dierich, A., Benoist, C. & Mathis, D., Nov 15 2002, In : Science. 298, 5597, p. 1395-1401 7 p.

Research output: Contribution to journalArticle

Autoimmunity
Thymus Gland
Autoimmune Diseases
Transcription Factors
Central Tolerance
2000
130 Citations (Scopus)

Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2

Chen, Z., Koralov, S. B. & Kelsoe, G., Nov 6 2000, In : Journal of Experimental Medicine. 192, 9, p. 1339-1351 13 p.

Research output: Contribution to journalArticle

Complement C4
Complement Receptors
Autoimmunity
Antinuclear Antibodies
Antigen-Antibody Complex
81 Citations (Scopus)

Humoral immune responses in Cr2(-/-) mice: Enhanced affinity maturation but impaired antibody persistence

Chen, Z., Koralov, S. B., Gendelman, M., Carroll, M. C. & Kelsoe, G., May 1 2000, In : Journal of Immunology. 164, 9, p. 4522-4532 11 p.

Research output: Contribution to journalArticle

Germinal Center
Humoral Immunity
Antibodies
B-Lymphocytes
Serum
28 Citations (Scopus)

Regulation of humoral immune responses by CD21/CD35

Chen, Z., Koralov, S. B. & Kelsoe, G., Sep 30 2000, In : Immunological Reviews. 176, p. 194-204 11 p.

Research output: Contribution to journalArticle

B-Cell Antigen Receptors
Humoral Immunity
B-Lymphocytes
Antigens
Germinal Center