Zhibin Chen

Associate Professor

  • 3324 Citations
20002018

Research output per year

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Research Output

  • 3324 Citations
  • 29 Article
  • 5 Review article
  • 1 Editorial
2000

Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2

Chen, Z., Koralov, S. B. & Kelsoe, G., Nov 6 2000, In : Journal of Experimental Medicine. 192, 9, p. 1339-1351 13 p.

Research output: Contribution to journalArticle

133 Scopus citations

Humoral immune responses in Cr2(-/-) mice: Enhanced affinity maturation but impaired antibody persistence

Chen, Z., Koralov, S. B., Gendelman, M., Carroll, M. C. & Kelsoe, G., May 1 2000, In : Journal of Immunology. 164, 9, p. 4522-4532 11 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

Regulation of humoral immune responses by CD21/CD35

Chen, Z., Koralov, S. B. & Kelsoe, G., Jan 1 2000, In : Immunological reviews. 176, p. 194-204 11 p.

Research output: Contribution to journalReview article

28 Scopus citations
2002

Projection of an immunological self shadow within the thymus by the aire protein

Anderson, M. S., Venanzi, E. S., Klein, L., Chen, Z., Berzins, S. P., Turley, S. J., Von Boehmer, H., Bronson, R., Dierich, A., Benoist, C. & Mathis, D., Nov 15 2002, In : Science. 298, 5597, p. 1395-1401 7 p.

Research output: Contribution to journalArticle

1658 Scopus citations
2003

Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand

Martin-Orozco, N., Chen, Z., Poirot, L., Hyatt, E., Chen, A., Kanagawa, O., Sharpe, A., Mathis, D. & Benoist, C., Dec 15 2003, In : Journal of Immunology. 171, 12, p. 6954-6960 7 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations
2005

Feedback inhibition of leptin receptor/Jak2 signaling via Tyr 1138 of the leptin receptor and suppressor of cytokine signaling 3

Dunn, S. L., Björnholm, M., Bates, S. H., Chen, Z., Seifert, M. & Myers, M. G., Apr 1 2005, In : Molecular Endocrinology. 19, 4, p. 925-938 14 p.

Research output: Contribution to journalArticle

105 Scopus citations

How defects in central tolerance impinge on a deficiency in regulatory T cells

Chen, Z., Benoist, C. & Mathis, D., Oct 11 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 41, p. 14735-14740 6 p.

Research output: Contribution to journalArticle

97 Scopus citations

The cellular mechanism of Aire control of T cell tolerance

Anderson, M. S., Venanzi, E. S., Chen, Z., Berzins, S. P., Benoist, C. & Mathis, D., Aug 1 2005, In : Immunity. 23, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

449 Scopus citations

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

Chen, Z., Herman, A. E., Matos, M., Mathis, D. & Benoist, C., Nov 21 2005, In : Journal of Experimental Medicine. 202, 10, p. 1387-1397 11 p.

Research output: Contribution to journalArticle

224 Scopus citations
2006

Modeling CTLA4-linked autoimmunity with RNA interference in mice

Chen, Z., Stockton, J., Mathis, D. & Benoist, C., Oct 31 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 44, p. 16400-16405 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
2007

Lack of Foxp3 function and expression in the thymic epithelium

Liston, A., Farr, A. G., Chen, Z., Benoist, C., Mathis, D., Manley, N. R. & Rudensky, A. Y., Mar 19 2007, In : Journal of Experimental Medicine. 204, 3, p. 475-480 6 p.

Research output: Contribution to journalArticle

50 Scopus citations
2008

CEACAM1 and the regulation of mucosal inflammation

Nagaishi, T., Chen, Z., Chen, L., Iijima, H., Nakajima, A. & Blumberg, R. S., Nov 2008, In : Mucosal Immunology. 1, p. 39-42 4 p.

Research output: Contribution to journalReview article

16 Scopus citations
2010

Immune tolerance induction by integrating innate and adaptive immune regulators

Suzuki, J., Ricordi, C. & Chen, Z., Jun 25 2010, In : Cell Transplantation. 19, 3, p. 253-268 16 p.

Research output: Contribution to journalReview article

24 Scopus citations

Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells

Vendrame, F., Pileggi, A., Laughlin, E., Allende, G., Martin-Pagola, A., Molano, R. D., Diamantopoulos, S., Standifer, N., Geubtner, K., Falk, B. A., Ichii, H., Takahashi, H., Snowhite, I., Chen, Z., Mendez, A., Chen, L., Sageshima, J., Ruiz, P., Ciancio, G., Ricordi, C. & 4 others, Reijonen, H., Nepom, G. T., Burke, G. W. & Pugliese, A., Apr 1 2010, In : Diabetes. 59, 4, p. 947-957 11 p.

Research output: Contribution to journalArticle

135 Scopus citations
2011

Induction of self-antigen-specific Foxp3+ regulatory T cells in the periphery by lymphodepletion treatment with anti-mouse thymocyte globulin in mice

Lu, Y., Suzuki, J., Guillioli, M., Umland, O. & Chen, Z., Sep 1 2011, In : Immunology. 134, 1, p. 50-59 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Autoimmunity-mediated antitumor immunity: Tumor as an immunoprivileged self

Miska, J., Bas, E., Devarajan, P. & Chen, Z., Oct 1 2012, In : European Journal of Immunology. 42, 10, p. 2584-2596 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

From biomarkers to a clue of biology: A computation-aided perspective of immune gene expression profiles in human type 1 diabetes

Han, D., Cai, X., Wen, J., Kenyon, N. S. & Chen, Z., Dec 1 2012, In : Frontiers in immunology. 3, OCT, Article 320.

Research output: Contribution to journalReview article

6 Scopus citations

Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes

Han, D., Cai, X., Wen, J., Matheson, D., Skyler, J. S., Kenyon, N. S. & Chen, Z., Nov 1 2012, In : Clinical and Experimental Immunology. 170, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

A Biophysical Model for Identifying Splicing Regulatory Elements and Their Interactions

Wen, J., Chen, Z. & Cai, X., Jan 30 2013, In : PloS one. 8, 1, e54885.

Research output: Contribution to journalArticle

5 Scopus citations

Autoimmune effector memory T cells: The bad and the good

Devarajan, P. & Chen, Z., Dec 1 2013, In : Immunologic Research. 57, 1-3, p. 12-22 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

The immunological identity of tumor: Self implications

Miska, J., Devarajan, P. & Chen, Z., Apr 1 2013, In : OncoImmunology. 2, 4, e23794.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Autoimmunity as a double agent in tumor killing and cancer promotion

Toomer, K. H. & Chen, Z., Jan 1 2014, In : Frontiers in immunology. 5, MAR, Article 116.

Research output: Contribution to journalReview article

28 Scopus citations

Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots

Leiva, A. G., Chen, A. L., Devarajan, P., Chen, Z., Damanpour, S., Hall, J. A., Bianco, A. C., Li, J., Badiavas, E. V., Zaias, J., Miteva, M., Romanelli, P., Nouri, K. & Cao Wikramanayake, T., Jul 2014, In : Journal of Investigative Dermatology. 134, 7, p. 1817-1827 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue

Devarajan, P., Miska, J., Lui, J. B., Swieboda, D. & Chen, Z., Nov 1 2014, In : Journal of Immunology. 193, 9, p. 4368-4380 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance

Miska, J., Abdulreda, M. H., Devarajan, P., Lui, J. B., Suzuki, J., Pileggi, A., Berggren, P. O. & Chen, Z., Mar 1 2014, In : Journal of Experimental Medicine. 211, 3, p. 441-456 16 p.

Research output: Contribution to journalArticle

37 Scopus citations
2015

Conversion of the CD8 lineage to CD4 T cells

Guzman, M. P. & Chen, Z., Jan 1 2015, In : Oncotarget. 6, 25, p. 20748-20749 2 p.

Research output: Contribution to journalEditorial

Open Access

Cross-differentiation from the CD8 lineage to CD4T cells in the gut-associated microenvironment with a nonessential role of microbiota

Lui, J. B., Devarajan, P., Teplicki, S. A. & Chen, Z., Feb 3 2015, In : Cell Reports. 10, 4, p. 574-585 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Erratum to Cross-Differentiation from the CD8 Lineage to CD4 T Cells in the Gut-Associated Microenvironment with a Nonessential Role of Microbiota [Cell Reports, 10, 4, (2015), 574-585]

Lui, J. B., Devarajan, P., Teplicki, S. A. & Chen, Z., Jun 23 2015, In : Cell Reports. 11, 11, p. 1844-1845 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Genome-wide analysis of alternative transcripts in human breast cancer

Wen, J., Toomer, K. H., Chen, Z. & Cai, X., Apr 26 2015, In : Breast Cancer Research and Treatment. 151, 2, p. 295-307 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Breast cancers from black women exhibit higher numbers of immunosuppressive macrophages with proliferative activity and of crown-like structures associated with lower survival compared to non-black Latinas and Caucasians

Koru-Sengul, T., Santander, A. M., Miao, F., Sanchez, L. G., Jorda, M., Glück, S., Ince, T. A., Nadji, M., Chen, Z., Penichet, M. L., Cleary, M. P. & Torroella-Kouri, M., Jul 1 2016, In : Breast cancer research and treatment. 158, 1, p. 113-126 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Gut microbiota amplifies host-intrinsic conversion from the CD8 T cell lineage to CD4 T cells for induction of mucosal immune tolerance

Lui, J. B., McGinn, L. S. & Chen, Z., Jan 2 2016, In : Gut Microbes. 7, 1, p. 40-47 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice

Dwyer, C. J., Bayer, A. L., Fotino, C., Yu, L., Cabello-Kindelan, C., Ward, N. C., Toomer, K. H., Chen, Z. & Malek, T., Dec 19 2017, In : Science Signaling. 10, 510, eaam9563.

Research output: Contribution to journalArticle

6 Scopus citations
2018

Identification of a gene-expression predictor for diagnosis and personalized stratification of lupus patients

Ding, Y., Li, H., He, X., Liao, W., Yi, Z., Yi, J., Chen, Z., Moore, D. J., Yi, Y. & Xiang, W., Jul 1 2018, In : PLoS One. 13, 7, e0198325.

Research output: Contribution to journalArticle

5 Scopus citations

Identification of epigenetic modulators in human breast cancer by integrated analysis of DNA methylation and RNA-Seq data

Zhou, X., Chen, Z. & Cai, X., Jan 1 2018, (Accepted/In press) In : Epigenetics.

Research output: Contribution to journalArticle

2 Scopus citations

Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines

Miska, J., Lui, J. B., Toomer, K. H., Devarajan, P., Cai, X., Houghton, J. M., Lopez, D. M., Abreu, M. T., Wang, G. & Chen, Z., Mar 1 2018, In : Journal of Experimental Medicine. 215, 3, p. 841-858 18 p.

Research output: Contribution to journalArticle

4 Scopus citations