Xue Z Liu

Professor

  • 6741 Citations
1993 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Congenital Middle Ear Malformation with Common Deafness Gene Mutation Analysis: A Review of 813 Profound Sensorineural Hearing Loss Child Patients

Dong, Y., He, X., Wu, W., Yang, S., Peng, A., Xiao, Z., Liu, Y., Gao, S., Tan, D., Liu, X. Z. & Xie, D., Mar 1 2020, In : Anatomical Record. 303, 3, p. 594-599 6 p.

Research output: Contribution to journalArticle

Progressive Dominant Hearing Loss (Autosomal Dominant Deafness-41) and P2RX2 Gene Mutations: A Phenotype–Genotype Study

Liu, X. Z., Yan, D., Mittal, R., Ballard, M. E. & Feng, Y., Jul 1 2020, In : Laryngoscope. 130, 7, p. 1657-1663 7 p.

Research output: Contribution to journalArticle

The Generation of Zebrafish Mariner Model Using the CRISPR/Cas9 System

Zou, B., Desmidt, A. A., Mittal, R., Yan, D., Richmond, M., Tekin, M., Liu, X. Z. & Lu, Z., Mar 1 2020, In : Anatomical Record. 303, 3, p. 556-562 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transcriptomic Analyses of Inner Ear Sensory Epithelia in Zebrafish

Yao, Q., Wang, L., Mittal, R., Yan, D., Richmond, M. T., Denyer, S., Requena, T., Liu, K., Varshney, G. K., Lu, Z. & Liu, X. Z., Mar 1 2020, In : Anatomical Record. 303, 3, p. 527-543 17 p.

Research output: Contribution to journalArticle

Zebrafish Model for Nonsyndromic X-Linked Sensorineural Deafness, DFNX1

DeSmidt, A. A., Zou, B., Grati, MH., Yan, D., Mittal, R., Yao, Q., Richmond, M. T., Denyer, S., Liu, X. Z. & Lu, Z., Mar 1 2020, In : Anatomical Record. 303, 3, p. 544-555 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2019

A novel ABHD12 nonsense variant in Usher syndrome type 3 family with genotype-phenotype spectrum review

Li, T., Feng, Y., Liu, Y., He, C., Liu, J., Chen, H., Deng, Y., Li, M., Li, W., Song, J., Niu, Z., Sang, S., Wen, J., Men, M., Chen, X., Li, J., Liu, X. & Ling, J., Jul 1 2019, In : Gene. 704, p. 113-120 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

ClinGen expert clinical validity curation of 164 hearing loss gene–disease pairs

on behalf of the ClinGen Hearing Loss Clinical Domain Working Group, Oct 1 2019, In : Genetics in Medicine. 21, 10, p. 2239-2247 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Concurrent Hearing and Genetic Screening of 180,469 Neonates with Follow-up in Beijing, China

Dai, P., Huang, L. H., Wang, G. J., Gao, X., Qu, C. Y., Chen, X. W., Ma, F. R., Zhang, J., Xing, W. L., Xi, S. Y., Ma, B. R., Pan, Y., Cheng, X. H., Duan, H., Yuan, Y. Y., Zhao, L. P., Chang, L., Gao, R. Z., Liu, H. H., Zhang, W. & 26 others, Huang, S. S., Kang, D. Y., Liang, W., Zhang, K., Jiang, H., Guo, Y. L., Zhou, Y., Zhang, W. X., Lyu, F., Jin, Y. N., Zhou, Z., Lu, H. L., Zhang, X., Liu, P., Ke, J., Hao, J. S., Huang, H. M., Jiang, D., Ni, X., Long, M., Zhang, L., Qiao, J., Morton, C. C., Liu, X. Z., Cheng, J. & Han, D. M., Oct 3 2019, In : American journal of human genetics. 105, 4, p. 803-812 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Consensus interpretation of the p.Met34Thr and p.Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel

on behalf of the ClinGen Hearing Loss Working Group, Nov 1 2019, In : Genetics in Medicine. 21, 11, p. 2442-2452 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
Open Access
1 Scopus citations

Elmod3 knockout leads to progressive hearing loss and abnormalities in cochlear hair cell stereocilia

Li, W., Feng, Y., Chen, A., Li, T., Huang, S., Liu, J., Liu, X., Liu, Y., Gao, J., Yan, D., Sun, J., Mei, L., Liu, X. & Ling, J., Dec 15 2019, In : Human molecular genetics. 28, 24, p. 4103-4112 10 p.

Research output: Contribution to journalArticle

Extrusion pump ABCC1 was first linked with nonsyndromic hearing loss in humans by stepwise genetic analysis

Li, M., Mei, L., He, C., Chen, H., Cai, X., Liu, Y., Tian, R., Tian, Q., Song, J., Jiang, L., Liu, C., Wu, H., Li, T., Liu, J., Li, X., Yi, Y., Yan, D., Blanton, S. H., Hu, Z., Liu, X. & 3 others, Li, J., Ling, J. & Feng, Y., Dec 1 2019, In : Genetics in Medicine. 21, 12, p. 2744-2754 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification

Undiagnosed Diseases Network, Jun 6 2019, In : American journal of human genetics. 104, 6, p. 1127-1138 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Magnetic Resonance Imaging characteristics in case of TOR1AIP1 muscular dystrophy

Undiagnosed Diseases Network (UDN) & Members of the Undiagnosed Diseases Network, Nov 1 2019, In : Clinical Imaging. 58, p. 108-113 6 p.

Research output: Contribution to journalArticle

New Genotypes and Phenotypes in Patients with 3 Subtypes of Waardenburg Syndrome Identified by Diagnostic Next-Generation Sequencing

Li, W., Mei, L., Chen, H., Cai, X., Liu, Y., Men, M., Liu, X. Z., Yan, D., Ling, J., Feng, Y. & Dorszewska, J., 2019, In : Neural Plasticity. 2019, 7143458.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Otopathogenic Staphylococcus aureus Invades Human Middle Ear Epithelial Cells Primarily through Cholesterol Dependent Pathway

Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Blackwelder, P., Yan, D., Weckwerth, P. H. & Liu, X. Z., Dec 1 2019, In : Scientific reports. 9, 1, 10777.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Preclinical assessment of MEK1/2 inhibitors for neurofibromatosis type 2-associated schwannomas reveals differences in efficacy and drug resistance development

Fuse, M. A., Dinh, C. T., Vitte, J., Kirkpatrick, J., Mindos, T., Plati, S. K., Young, J. I., Huang, J., Carlstedt, A., Franco, M. C., Brnjos, K., Nagamoto, J., Petrilli, A. M., Copik, A. J., Soulakova, J. N., Bracho, O., Yan, D., Mittal, R., Shen, R., Telischi, F. F. & 5 others, Morrison, H., Giovannini, M., Liu, X. Z., Chang, L. S. & Fernandez-Valle, C., Mar 18 2019, In : Neuro-Oncology. 21, 4, p. 486-497 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Renewed proliferation in adult mouse cochlea and regeneration of hair cells

Shu, Y., Li, W., Huang, M., Quan, Y. Z., Scheffer, D., Tian, C., Tao, Y., Liu, X., Hochedlinger, K., Indzhykulian, A. A., Wang, Z., Li, H. & Chen, Z. Y., Dec 1 2019, In : Nature communications. 10, 1, 5530.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss

Wang, L., Feng, Y., Yan, D., Qin, L., Grati, MH., Mittal, R., Li, T., Sundhari, A. K., Liu, Y., Chapagain, P., Blanton, S. H., Liao, S. & Liu, X., Jul 1 2018, In : Human genetics. 137, 6-7, p. 437-446 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Amino acid 118 in the deafness causing (DFNA20/26) ACTG1 gene is a mutational hot spot

Wang, L., Yan, D., Qin, L., Li, T., Liu, H., Li, W., Mittal, R., Yong, F., Chapagain, P., Liao, S. & Liu, X., Jun 1 2018, In : Gene Reports. 11, p. 264-269 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

A novel splicing mutation in SMPX is linked to nonsyndromic progressive hearing loss

Niu, Z., Yan, D., Bressler, S., Mei, L., Feng, Y. & Liu, X. Z., Jan 1 2018, In : International Journal of Pediatric Otorhinolaryngology. 104, p. 47-50 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

A xenograft model of vestibular schwannoma and hearing loss

Dinh, C. T., Bracho, O., Mei, C., Bas, E., Fernandez-Valle, C., Telischi, F. & Liu, X. Z., Jun 1 2018, In : Otology and Neurotology. 39, 5, p. e362-e369

Research output: Contribution to journalArticle

3 Scopus citations

ELMOD3, a novel causative gene, associated with human autosomal dominant nonsyndromic and progressive hearing loss

Li, W., Sun, J., Ling, J., Li, J., He, C., Liu, Y., Chen, H., Men, M., Niu, Z., Deng, Y., Li, M., Li, T., Wen, J., Sang, S., Li, H., Wan, Z., Richard, E. M., Chapagain, P., Yan, D., Liu, X. Z. & 2 others, Mei, L. & Feng, Y., Apr 1 2018, In : Human genetics. 137, 4, p. 329-342 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

First locally acquired congenital zika syndrome case in the United States: Neonatal clinical manifestations

Ventura, C. V., Bandstra, E. S., Fernandez, M. P., Cooper, J. M., Saigal, G., Bauer, C. R., Hofheimer, J. A., Berkovits, M., Fifer, R., Pensirikul, A., Gonzalez, I., Curry, C., Andreansky, S., Younis, R. T., Liu, X. Z., Banker, T., Dubovy, S., Langer, S. M. & Berrocal, A., Sep 1 2018, In : Ophthalmic Surgery Lasers and Imaging Retina. 49, 9, p. e93-e98

Research output: Contribution to journalArticle

3 Scopus citations

Fluorescent detection of Merlin-deficient Schwann cells and primary human vestibular schwannoma cells using sodium fluorescein

Perez, E. R., Bracho, O., Ein, L., Szczupak, M., Monje, P. V., Fernandez-Valle, C., Alshaiji, A., Ivan, M., Morcos, J., Liu, X. Z., Hoffer, M., Eshraghi, A., Angeli, S., Telischi, F. & Dinh, C. T., Jan 1 2018, In : Otology and Neurotology. 39, 8, p. 1053-1059 7 p.

Research output: Contribution to journalArticle

Precision medicine in hearing loss

Rudman, J. R., Mei, C., Bressler, S. E., Blanton, S. H. & Liu, X. Z., Jan 1 2018, (Accepted/In press) In : Journal of Genetics and Genomics.

Research output: Contribution to journalArticle

5 Scopus citations

Targeted Next-Generation Sequencing of a Deafness Gene Panel (MiamiOtoGenes) Analysis in Families Unsuitable for Linkage Analysis

Shang, H., Yan, D., Tayebi, N., Saeidi, K., Sahebalzamani, A., Feng, Y., Blanton, S. & Liu, X., 2018, In : BioMed research international. 2018, 3103986.

Research output: Contribution to journalArticle

7 Scopus citations
2017

A novel frameshift mutation of SMPX causes a rare form of X-linked nonsyndromic hearing loss in a Chinese family

Niu, Z., Feng, Y., Mei, L., Sun, J., Wang, X., Wang, J., Hu, Z., Dong, Y., Chen, H., He, C., Liu, Y., Cai, X., Liu, X. & Jiang, L., May 2017, In : PloS one. 12, 5, e0178384.

Research output: Contribution to journalArticle

9 Scopus citations

Combination therapy with c-Met and Src inhibitors induces caspase-dependent apoptosis of merlin-deficient Schwann cells and suppresses growth of schwannoma cells

Fuse, M. A., Plati, S. K., Burns, S. S., Dinh, C. T., Bracho, O., Yan, D., Mittal, R., Shen, R., Soulakova, J. N., Copik, A. J., Liu, X. Z., Telischi, F. F., Chang, L. S., Franco, M. C. & Fernandez-Valle, C., Nov 2017, In : Molecular cancer therapeutics. 16, 11, p. 2387-2398 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Exome sequencing identifies a novel missense mutation of WFS1 as the cause of non-syndromic low-frequency hearing loss in a Chinese family

Niu, Z., Feng, Y., Hu, Z., Li, J., Sun, J., Chen, H., He, C., Wang, X., Jiang, L., Liu, Y., Cai, X., Wang, L., Cai, Y., Liu, X. Z. & Mei, L., Sep 1 2017, In : International Journal of Pediatric Otorhinolaryngology. 100, p. 1-7 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Exome sequencing identifies POU4F3 as the causative gene for a large Chinese family with non-syndromic hearing loss

Cai, X. Z., Li, Y., Xia, L., Peng, Y., He, C. F., Jiang, L., Feng, Y., Xia, K., Liu, X. Z., Mei, L. Y. & Hu, Z. M., Feb 1 2017, In : Journal of Human Genetics. 62, 2, p. 317-320 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genetic screening revealed usher syndrome in a paediatric Chinese patient

Qu, C., Liang, F., Long, Q., Zhao, M., Shang, H., Fan, L., Wang, L., Yan, D. & Liu, X., Apr 3 2017, In : Hearing, Balance and Communication. 15, 2, p. 98-106 9 p.

Research output: Contribution to journalArticle

Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells

Petrilli, A. M., Garcia, J., Bott, M., Plati, S. K., Dinh, C. T., Bracho, O. R., Yan, D., Zou, B., Mittal, R., Telischi, F. F., Liu, X. Z., Chang, L. S., Welling, D. B., Copik, A. J. & Fernández-Valle, C., 2017, In : Oncotarget. 8, 19, p. 31666-31681 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Screening of deafness-causing DNA variants that are common in patients of European ancestry using a microarray-based approach

Yan, D., Xiang, G., Chai, X., Qing, J., Shang, H., Mittal, B. Z. R., Shen, J., Smith, R. J. H., Fan, Y. S., Blanton, S. H., Tekin, M., Morton, C., Xing, W., Cheng, J. & Liu, X. Z., Mar 2017, In : PloS one. 12, 3, e0169219.

Research output: Contribution to journalArticle

14 Scopus citations

Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function

Mittal, R., Debs, L. H., Nguyen, D., Patel, A. P., Grati, MH., Mittal, J., Yan, D., Eshraghi, A. A. & Liu, X. Z., 2017, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

5 Scopus citations

The advances in hearing rehabilitation and cochlear implants in China

Li, J. N., Chen, S., Zhai, L., Han, D. Y., Eshraghi, A. A., Feng, Y., Yang, S. M. & Liu, X. Z., Jan 1 2017, In : Ear and hearing. 38, 6, p. 647-652 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Abnormal mRNA splicing but normal auditory brainstem response (ABR) in mice with the prestin (SLC26A5) IVS2-2A > G mutation

Zhang, J., Liu, Z., Chang, A., Fang, J., Men, Y., Tian, Y., Ouyang, X., Yan, D., Zhang, A., Sun, X., Tang, J., Liu, X., Zuo, J. & Gao, J., Aug 1 2016, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 790, p. 1-7 7 p.

Research output: Contribution to journalArticle

A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60

Ben Said, M., Grati, MH., Ishimoto, T., Zou, B., Chakchouk, I., Ma, Q., Yao, Q., Hammami, B., Yan, D., Mittal, R., Nakamichi, N., Ghorbel, A., Neng, L., Tekin, M., Shi, X. R., Kato, Y., Masmoudi, S., Lu, Z., Hmani, M. & Liu, X., May 1 2016, In : Human genetics. 135, 5, p. 513-524 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

A next-generation sequencing gene panel (MiamiOtoGenes) for comprehensive analysis of deafness genes

Tekin, D., Yan, D., Bademci, G., Feng, Y., Guo, S., Foster, J., Blanton, S. H., Tekin, M. & Liu, X. Z., Mar 1 2016, In : Hearing Research. 333, p. 179-184 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Characterization of ATPase activity of P2RX2 cation channel

Mittal, R., Grati, M., Sedlacek, M., Yuan, F., Chang, Q., Yan, D., Lin, X., Kachar, B., Farooq, A., Chapagain, P., Zhang, Y. & Liu, X. Z., 2016, In : Frontiers in Physiology. 7, MAY, 186.

Research output: Contribution to journalArticle

4 Scopus citations
13 Scopus citations

CRISPR: a versatile tool for both forward and reverse genetics research

Gurumurthy, C. B., Grati, MH., Ohtsuka, M., Schilit, S. L. P., Quadros, R. M. & Liu, X. Z., Sep 1 2016, In : Human Genetics. 135, 9, p. 971-976 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Functional characterization of a novel loss-of-function mutation of PRPS1 related to early-onset progressive nonsyndromic hearing loss in Koreans (DFNX1): Potential implications on future therapeutic intervention

Kim, S. Y., Kim, A. R., Kim, N. K. D., Lee, C., Han, J. H., Kim, M. Y., Jeon, E. H., Park, W. Y., Mittal, R., Yan, D., Liu, X. Z. & Choi, B. Y., Nov 1 2016, In : Journal of Gene Medicine. 18, 11-12, p. 353-358 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hearing Assessment in Zebrafish during the First Week Postfertilization

Yao, Q., Desmidt, A. A., Tekin, M., Liu, X. Z. & Lu, Z., Apr 1 2016, In : Zebrafish. 13, 2, p. 79-86 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Indispensable Role of Ion Channels and Transporters in the Auditory System

Mittal, R., Aranke, M., Debs, L. H., Nguyen, D., Patel, A. P., Grati, MH., Mittal, J., Yan, D., Chapagain, P., Eshraghi, A. A. & Liu, X. Z., 2016, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

19 Scopus citations

MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform

Grati, MH., Yan, D., Raval, M. H., Walsh, T., Ma, Q., Chakchouk, I., Kannan-Sundhari, A., Mittal, R., Masmoudi, S., Blanton, S. H., Tekin, M., King, M. C., Yengo, C. M. & Liu, X. Z., 2016, (Accepted/In press) In : Human Mutation.

Research output: Contribution to journalArticle

11 Scopus citations

Otopathogenic Pseudomonas aeruginosa enters and survives inside macrophages

Mittal, R., Lisi, C. V., Kumari, H., Grati, M., Blackwelder, P., Yan, D., Jain, C., Mathee, K., Weckwerth, P. H. & Liu, X. Z., Nov 18 2016, In : Frontiers in Microbiology. 7, NOV, 1828.

Research output: Contribution to journalArticle

5 Scopus citations

PDZD7-MYO7A complex identified in enriched stereocilia membranes

Morgan, C. P., Krey, J. F., Grati, M., Zhao, B., Fallen, S., Kannan-Sundhari, A., Liu, X. Z., Choi, D., Müller, U. & Barr-Gillespie, P. G., Aug 15 2016, In : eLife. 5, AUGUST, e18312.

Research output: Contribution to journalArticle

15 Scopus citations

Pseudomonas aeruginosa activates PKC-alpha to invade middle ear epithelial cells

Mittal, R., Grati, M., Yan, D. & Liu, X. Z., Mar 4 2016, In : Frontiers in Microbiology. 7, MAR, 255.

Research output: Contribution to journalArticle

5 Scopus citations