Xue Z Liu

Professor

  • 6741 Citations
1993 …2020

Research output per year

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Research Output

2020

Congenital Middle Ear Malformation with Common Deafness Gene Mutation Analysis: A Review of 813 Profound Sensorineural Hearing Loss Child Patients

Dong, Y., He, X., Wu, W., Yang, S., Peng, A., Xiao, Z., Liu, Y., Gao, S., Tan, D., Liu, X. Z. & Xie, D., Mar 1 2020, In : Anatomical Record. 303, 3, p. 594-599 6 p.

Research output: Contribution to journalArticle

Progressive Dominant Hearing Loss (Autosomal Dominant Deafness-41) and P2RX2 Gene Mutations: A Phenotype–Genotype Study

Liu, X. Z., Yan, D., Mittal, R., Ballard, M. E. & Feng, Y., Jul 1 2020, In : Laryngoscope. 130, 7, p. 1657-1663 7 p.

Research output: Contribution to journalArticle

The Generation of Zebrafish Mariner Model Using the CRISPR/Cas9 System

Zou, B., Desmidt, A. A., Mittal, R., Yan, D., Richmond, M., Tekin, M., Liu, X. Z. & Lu, Z., Mar 1 2020, In : Anatomical Record. 303, 3, p. 556-562 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transcriptomic Analyses of Inner Ear Sensory Epithelia in Zebrafish

Yao, Q., Wang, L., Mittal, R., Yan, D., Richmond, M. T., Denyer, S., Requena, T., Liu, K., Varshney, G. K., Lu, Z. & Liu, X. Z., Mar 1 2020, In : Anatomical Record. 303, 3, p. 527-543 17 p.

Research output: Contribution to journalArticle

Zebrafish Model for Nonsyndromic X-Linked Sensorineural Deafness, DFNX1

DeSmidt, A. A., Zou, B., Grati, MH., Yan, D., Mittal, R., Yao, Q., Richmond, M. T., Denyer, S., Liu, X. Z. & Lu, Z., Mar 1 2020, In : Anatomical Record. 303, 3, p. 544-555 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2019

A novel ABHD12 nonsense variant in Usher syndrome type 3 family with genotype-phenotype spectrum review

Li, T., Feng, Y., Liu, Y., He, C., Liu, J., Chen, H., Deng, Y., Li, M., Li, W., Song, J., Niu, Z., Sang, S., Wen, J., Men, M., Chen, X., Li, J., Liu, X. & Ling, J., Jul 1 2019, In : Gene. 704, p. 113-120 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

ClinGen expert clinical validity curation of 164 hearing loss gene–disease pairs

on behalf of the ClinGen Hearing Loss Clinical Domain Working Group, Oct 1 2019, In : Genetics in Medicine. 21, 10, p. 2239-2247 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Concurrent Hearing and Genetic Screening of 180,469 Neonates with Follow-up in Beijing, China

Dai, P., Huang, L. H., Wang, G. J., Gao, X., Qu, C. Y., Chen, X. W., Ma, F. R., Zhang, J., Xing, W. L., Xi, S. Y., Ma, B. R., Pan, Y., Cheng, X. H., Duan, H., Yuan, Y. Y., Zhao, L. P., Chang, L., Gao, R. Z., Liu, H. H., Zhang, W. & 26 others, Huang, S. S., Kang, D. Y., Liang, W., Zhang, K., Jiang, H., Guo, Y. L., Zhou, Y., Zhang, W. X., Lyu, F., Jin, Y. N., Zhou, Z., Lu, H. L., Zhang, X., Liu, P., Ke, J., Hao, J. S., Huang, H. M., Jiang, D., Ni, X., Long, M., Zhang, L., Qiao, J., Morton, C. C., Liu, X. Z., Cheng, J. & Han, D. M., Oct 3 2019, In : American journal of human genetics. 105, 4, p. 803-812 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Consensus interpretation of the p.Met34Thr and p.Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel

on behalf of the ClinGen Hearing Loss Working Group, Nov 1 2019, In : Genetics in Medicine. 21, 11, p. 2442-2452 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Correction: ClinGen expert clinical validity curation of 164 hearing loss gene–disease pairs (Genetics in Medicine, (2019), 21, 10, (2239-2247), 10.1038/s41436-019-0487-0)

on behalf of the ClinGen Hearing Loss Clinical Domain Working Group, Oct 1 2019, In : Genetics in Medicine. 21, 10, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Open Access
1 Scopus citations

Elmod3 knockout leads to progressive hearing loss and abnormalities in cochlear hair cell stereocilia

Li, W., Feng, Y., Chen, A., Li, T., Huang, S., Liu, J., Liu, X., Liu, Y., Gao, J., Yan, D., Sun, J., Mei, L., Liu, X. & Ling, J., Dec 15 2019, In : Human molecular genetics. 28, 24, p. 4103-4112 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Extrusion pump ABCC1 was first linked with nonsyndromic hearing loss in humans by stepwise genetic analysis

Li, M., Mei, L., He, C., Chen, H., Cai, X., Liu, Y., Tian, R., Tian, Q., Song, J., Jiang, L., Liu, C., Wu, H., Li, T., Liu, J., Li, X., Yi, Y., Yan, D., Blanton, S. H., Hu, Z., Liu, X. & 3 others, Li, J., Ling, J. & Feng, Y., Dec 1 2019, In : Genetics in Medicine. 21, 12, p. 2744-2754 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Genetic screening as an adjunct to universal newborn hearing screening: literature review and implications for non-congenital pre-lingual hearing loss

D’Aguillo, C., Bressler, S., Yan, D., Mittal, R., Fifer, R., Blanton, S. H. & Liu, X., Dec 2 2019, In : International Journal of Audiology. 58, 12, p. 834-850 17 p.

Research output: Contribution to journalReview article

Genetics of Hearing Loss

Rudman, J. & Liu, X. Z., Apr 1 2019, In : Hearing Journal. 72, 4, p. 6-7 2 p.

Research output: Contribution to journalEditorial

Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification

Undiagnosed Diseases Network, Jun 6 2019, In : American journal of human genetics. 104, 6, p. 1127-1138 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Magnetic Resonance Imaging characteristics in case of TOR1AIP1 muscular dystrophy

Undiagnosed Diseases Network (UDN) & Members of the Undiagnosed Diseases Network, Nov 1 2019, In : Clinical Imaging. 58, p. 108-113 6 p.

Research output: Contribution to journalArticle

New Genotypes and Phenotypes in Patients with 3 Subtypes of Waardenburg Syndrome Identified by Diagnostic Next-Generation Sequencing

Li, W., Mei, L., Chen, H., Cai, X., Liu, Y., Men, M., Liu, X. Z., Yan, D., Ling, J., Feng, Y. & Dorszewska, J., 2019, In : Neural Plasticity. 2019, 7143458.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Otopathogenic Staphylococcus aureus Invades Human Middle Ear Epithelial Cells Primarily through Cholesterol Dependent Pathway

Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Blackwelder, P., Yan, D., Weckwerth, P. H. & Liu, X. Z., Dec 1 2019, In : Scientific reports. 9, 1, 10777.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Preclinical assessment of MEK1/2 inhibitors for neurofibromatosis type 2-associated schwannomas reveals differences in efficacy and drug resistance development

Fuse, M. A., Dinh, C. T., Vitte, J., Kirkpatrick, J., Mindos, T., Plati, S. K., Young, J. I., Huang, J., Carlstedt, A., Franco, M. C., Brnjos, K., Nagamoto, J., Petrilli, A. M., Copik, A. J., Soulakova, J. N., Bracho, O., Yan, D., Mittal, R., Shen, R., Telischi, F. F. & 5 others, Morrison, H., Giovannini, M., Liu, X. Z., Chang, L. S. & Fernandez-Valle, C., Mar 18 2019, In : Neuro-Oncology. 21, 4, p. 486-497 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Recent Perspectives on Gene-Microbe Interactions Determining Predisposition to Otitis Media

Mittal, R., Sanchez-Luege, S. V., Wagner, S. M., Yan, D. & Liu, X. Z., Nov 26 2019, In : Frontiers in Genetics. 10, 1230.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Renewed proliferation in adult mouse cochlea and regeneration of hair cells

Shu, Y., Li, W., Huang, M., Quan, Y. Z., Scheffer, D., Tian, C., Tao, Y., Liu, X., Hochedlinger, K., Indzhykulian, A. A., Wang, Z., Li, H. & Chen, Z. Y., Dec 1 2019, In : Nature communications. 10, 1, 5530.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Role of microRNAs in inner ear development and hearing loss

Mittal, R., Liu, G., Polineni, S. P., Bencie, N., Yan, D. & Liu, X. Z., Feb 20 2019, In : Gene. 686, p. 49-55 7 p.

Research output: Contribution to journalReview article

2 Scopus citations
2018

A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss

Wang, L., Feng, Y., Yan, D., Qin, L., Grati, MH., Mittal, R., Li, T., Sundhari, A. K., Liu, Y., Chapagain, P., Blanton, S. H., Liao, S. & Liu, X., Jul 1 2018, In : Human genetics. 137, 6-7, p. 437-446 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Amino acid 118 in the deafness causing (DFNA20/26) ACTG1 gene is a mutational hot spot

Wang, L., Yan, D., Qin, L., Li, T., Liu, H., Li, W., Mittal, R., Yong, F., Chapagain, P., Liao, S. & Liu, X., Jun 1 2018, In : Gene Reports. 11, p. 264-269 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

A novel splicing mutation in SMPX is linked to nonsyndromic progressive hearing loss

Niu, Z., Yan, D., Bressler, S., Mei, L., Feng, Y. & Liu, X. Z., Jan 1 2018, In : International Journal of Pediatric Otorhinolaryngology. 104, p. 47-50 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

An update on phosphodiesterase mutations underlying genetic etiology of hearing loss and retinitis pigmentosa

Mittal, R., Bencie, N., Parrish, J. M., Liu, G., Mittal, J., Yan, D. & Liu, X. Z., Feb 8 2018, In : Frontiers in Genetics. 9, FEB, 9.

Research output: Contribution to journalComment/debate

1 Scopus citations

A possible association between hearing loss and Zika virus infections

Mittal, R., Fifer, R. & Liu, X. Z., Jan 1 2018, In : JAMA Otolaryngology - Head and Neck Surgery. 144, 1, p. 3-4 2 p.

Research output: Contribution to journalComment/debate

7 Scopus citations

A xenograft model of vestibular schwannoma and hearing loss

Dinh, C. T., Bracho, O., Mei, C., Bas, E., Fernandez-Valle, C., Telischi, F. & Liu, X. Z., Jun 1 2018, In : Otology and Neurotology. 39, 5, p. e362-e369

Research output: Contribution to journalArticle

3 Scopus citations

ELMOD3, a novel causative gene, associated with human autosomal dominant nonsyndromic and progressive hearing loss

Li, W., Sun, J., Ling, J., Li, J., He, C., Liu, Y., Chen, H., Men, M., Niu, Z., Deng, Y., Li, M., Li, T., Wen, J., Sang, S., Li, H., Wan, Z., Richard, E. M., Chapagain, P., Yan, D., Liu, X. Z. & 2 others, Mei, L. & Feng, Y., Apr 1 2018, In : Human genetics. 137, 4, p. 329-342 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

First locally acquired congenital zika syndrome case in the United States: Neonatal clinical manifestations

Ventura, C. V., Bandstra, E. S., Fernandez, M. P., Cooper, J. M., Saigal, G., Bauer, C. R., Hofheimer, J. A., Berkovits, M., Fifer, R., Pensirikul, A., Gonzalez, I., Curry, C., Andreansky, S., Younis, R. T., Liu, X. Z., Banker, T., Dubovy, S., Langer, S. M. & Berrocal, A., Sep 1 2018, In : Ophthalmic Surgery Lasers and Imaging Retina. 49, 9, p. e93-e98

Research output: Contribution to journalArticle

3 Scopus citations

Fluorescent detection of Merlin-deficient Schwann cells and primary human vestibular schwannoma cells using sodium fluorescein

Perez, E. R., Bracho, O., Ein, L., Szczupak, M., Monje, P. V., Fernandez-Valle, C., Alshaiji, A., Ivan, M., Morcos, J., Liu, X. Z., Hoffer, M., Eshraghi, A., Angeli, S., Telischi, F. & Dinh, C. T., Jan 1 2018, In : Otology and Neurotology. 39, 8, p. 1053-1059 7 p.

Research output: Contribution to journalArticle

Genetic basis of hearing loss in Spanish, Hispanic and Latino populations

Mittal, R., Patel, A. P., Nguyen, D., Pan, D. R., Jhaveri, V. M., Rudman, J. R., Dharmaraja, A., Yan, D., Feng, Y., Chapagain, P., Lee, D. J., Blanton, S. H. & Liu, X. Z., Mar 20 2018, In : Gene. 647, p. 297-305 9 p.

Research output: Contribution to journalReview article

5 Scopus citations

Otosclerosis: From Genetics to Molecular Biology

Babcock, T. A. & Liu, X. Z., Apr 1 2018, In : Otolaryngologic Clinics of North America. 51, 2, p. 305-318 14 p.

Research output: Contribution to journalReview article

8 Scopus citations

Precision medicine in hearing loss

Rudman, J. R., Mei, C., Bressler, S. E., Blanton, S. H. & Liu, X. Z., Jan 1 2018, (Accepted/In press) In : Journal of Genetics and Genomics.

Research output: Contribution to journalArticle

5 Scopus citations

Targeted Next-Generation Sequencing of a Deafness Gene Panel (MiamiOtoGenes) Analysis in Families Unsuitable for Linkage Analysis

Shang, H., Yan, D., Tayebi, N., Saeidi, K., Sahebalzamani, A., Feng, Y., Blanton, S. & Liu, X., 2018, In : BioMed research international. 2018, 3103986.

Research output: Contribution to journalArticle

7 Scopus citations
2017

A novel frameshift mutation of SMPX causes a rare form of X-linked nonsyndromic hearing loss in a Chinese family

Niu, Z., Feng, Y., Mei, L., Sun, J., Wang, X., Wang, J., Hu, Z., Dong, Y., Chen, H., He, C., Liu, Y., Cai, X., Liu, X. & Jiang, L., May 2017, In : PloS one. 12, 5, e0178384.

Research output: Contribution to journalArticle

9 Scopus citations

Combination therapy with c-Met and Src inhibitors induces caspase-dependent apoptosis of merlin-deficient Schwann cells and suppresses growth of schwannoma cells

Fuse, M. A., Plati, S. K., Burns, S. S., Dinh, C. T., Bracho, O., Yan, D., Mittal, R., Shen, R., Soulakova, J. N., Copik, A. J., Liu, X. Z., Telischi, F. F., Chang, L. S., Franco, M. C. & Fernandez-Valle, C., Nov 2017, In : Molecular cancer therapeutics. 16, 11, p. 2387-2398 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
7 Scopus citations

Exome sequencing identifies a novel missense mutation of WFS1 as the cause of non-syndromic low-frequency hearing loss in a Chinese family

Niu, Z., Feng, Y., Hu, Z., Li, J., Sun, J., Chen, H., He, C., Wang, X., Jiang, L., Liu, Y., Cai, X., Wang, L., Cai, Y., Liu, X. Z. & Mei, L., Sep 1 2017, In : International Journal of Pediatric Otorhinolaryngology. 100, p. 1-7 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Exome sequencing identifies POU4F3 as the causative gene for a large Chinese family with non-syndromic hearing loss

Cai, X. Z., Li, Y., Xia, L., Peng, Y., He, C. F., Jiang, L., Feng, Y., Xia, K., Liu, X. Z., Mei, L. Y. & Hu, Z. M., Feb 1 2017, In : Journal of Human Genetics. 62, 2, p. 317-320 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genetic screening revealed usher syndrome in a paediatric Chinese patient

Qu, C., Liang, F., Long, Q., Zhao, M., Shang, H., Fan, L., Wang, L., Yan, D. & Liu, X., Apr 3 2017, In : Hearing, Balance and Communication. 15, 2, p. 98-106 9 p.

Research output: Contribution to journalArticle

Neurotransmitters: The Critical Modulators Regulating Gut–Brain Axis

Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Patel, K., O'Connor, G., Grati, MH., Mittal, J., Yan, D., Eshraghi, A. A., Deo, S. K., Daunert, S. & Liu, X. Z., Sep 2017, In : Journal of Cellular Physiology. 232, 9, p. 2359-2372 14 p.

Research output: Contribution to journalReview article

82 Scopus citations

Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells

Petrilli, A. M., Garcia, J., Bott, M., Plati, S. K., Dinh, C. T., Bracho, O. R., Yan, D., Zou, B., Mittal, R., Telischi, F. F., Liu, X. Z., Chang, L. S., Welling, D. B., Copik, A. J. & Fernández-Valle, C., 2017, In : Oncotarget. 8, 19, p. 31666-31681 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Recent advancements in the regeneration of auditory hair cells and hearing restoration

Mittal, R., Nguyen, D., Patel, A. P., Debs, L. H., Mittal, J., Yan, D., Eshraghi, A. A., Van De Water, T. R. & Liu, X. Z., Jul 31 2017, In : Frontiers in Molecular Neuroscience. 10, 236.

Research output: Contribution to journalReview article

25 Scopus citations

Role of cyclic nucleotide phosphodiesterases in inner ear and hearing

Mittal, R., Bencie, N., Shaikh, N., Mittal, J., Liu, X. Z. & Eshraghi, A. A., Nov 9 2017, In : Frontiers in Physiology. 8, NOV, 908.

Research output: Contribution to journalComment/debate

1 Scopus citations

Screening of deafness-causing DNA variants that are common in patients of European ancestry using a microarray-based approach

Yan, D., Xiang, G., Chai, X., Qing, J., Shang, H., Mittal, B. Z. R., Shen, J., Smith, R. J. H., Fan, Y. S., Blanton, S. H., Tekin, M., Morton, C., Xing, W., Cheng, J. & Liu, X. Z., Mar 2017, In : PloS one. 12, 3, e0169219.

Research output: Contribution to journalArticle

14 Scopus citations