Xue Z Liu

Professor

  • 6351 Citations
1993 …2023
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Research Output 1993 2019

2019
1 Citation (Scopus)

A novel ABHD12 nonsense variant in Usher syndrome type 3 family with genotype-phenotype spectrum review

Li, T., Feng, Y., Liu, Y., He, C., Liu, J., Chen, H., Deng, Y., Li, M., Li, W., Song, J., Niu, Z., Sang, S., Wen, J., Men, M., Chen, X., Li, J., Liu, X. Z. & Ling, J., Jul 1 2019, In : Gene. 704, p. 113-120 8 p.

Research output: Contribution to journalArticle

Usher Syndromes
Genotype
Phenotype
Deaf-Blind Disorders
Exome
3 Citations (Scopus)

ClinGen expert clinical validity curation of 164 hearing loss gene–disease pairs

on behalf of the ClinGen Hearing Loss Clinical Domain Working Group, Jan 1 2019, In : Genetics in Medicine.

Research output: Contribution to journalArticle

Hearing Loss
Genome
Genes
Genetic Testing
Registries

Correction: ClinGen expert clinical validity curation of 164 hearing loss gene–disease pairs (Genetics in Medicine, (2019), 10.1038/s41436-019-0487-0)

on behalf of the ClinGen Hearing Loss Clinical Domain Working Group, Jan 1 2019, (Accepted/In press) In : Genetics in Medicine.

Research output: Contribution to journalComment/debate

Open Access
Hearing Loss
Medicine
1 Citation (Scopus)
Open Access
Induced Pluripotent Stem Cells
Audition
Stem cells
Hearing Loss
Oligonucleotides

Extrusion pump ABCC1 was first linked with nonsyndromic hearing loss in humans by stepwise genetic analysis

Li, M., Mei, L., He, C., Chen, H., Cai, X., Liu, Y., Tian, R., Tian, Q., Song, J., Jiang, L., Liu, C., Wu, H., Li, T., Liu, J., Li, X., Yi, Y., Yan, D., Blanton, S. H., Hu, Z., Liu, X. & 3 others, Li, J., Ling, J. & Feng, Y., Jan 1 2019, In : Genetics in Medicine.

Research output: Contribution to journalArticle

Cochlea
Medical Genetics
Fluorescent Antibody Technique
Stria Vascularis
Exome
Genetic Testing
Hearing Loss
Tongue
Hearing
Newborn Infant

Genetics of Hearing Loss

Rudman, J. & Liu, X. Z., Apr 1 2019, In : Hearing Journal. 72, 4, p. 6-7 2 p.

Research output: Contribution to journalEditorial

Hearing Loss

New Genotypes and Phenotypes in Patients with 3 Subtypes of Waardenburg Syndrome Identified by Diagnostic Next-Generation Sequencing

Li, W., Mei, L., Chen, H., Cai, X., Liu, Y., Men, M., Liu, X. Z., Yan, D., Ling, J., Feng, Y. & Dorszewska, J., Jan 1 2019, In : Neural Plasticity. 2019, 7143458.

Research output: Contribution to journalArticle

Open Access
Waardenburg Syndrome
Genotype
Phenotype
Melanosis
Amblyopia
1 Citation (Scopus)

Otopathogenic Staphylococcus aureus Invades Human Middle Ear Epithelial Cells Primarily through Cholesterol Dependent Pathway

Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Blackwelder, P., Yan, D., Weckwerth, P. H. & Liu, X. Z., Dec 1 2019, In : Scientific reports. 9, 1, 10777.

Research output: Contribution to journalArticle

Open Access
Middle Ear
Suppurative Otitis Media
Staphylococcus aureus
Epithelial Cells
Cholesterol
2 Citations (Scopus)

Preclinical assessment of MEK1/2 inhibitors for neurofibromatosis type 2-associated schwannomas reveals differences in efficacy and drug resistance development

Fuse, M. A., Dinh, C. T., Vitte, J., Kirkpatrick, J., Mindos, T., Plati, S. K., Young, J., Huang, J., Carlstedt, A., Franco, M. C., Brnjos, K., Nagamoto, J., Petrilli, A. M., Copik, A. J., Soulakova, J. N., Bracho, O., Yan, D., Mittal, R., Shen, R., Telischi, F. F. & 5 others, Morrison, H., Giovannini, M., Liu, X. Z., Chang, L. S. & Fernandez-Valle, C., Mar 18 2019, In : Neuro-Oncology. 21, 4, p. 486-497 12 p.

Research output: Contribution to journalArticle

Neurofibromatosis 2
Neurilemmoma
Drug Resistance
Acoustic Neuroma
Neurofibromin 2

Role of microRNAs in inner ear development and hearing loss

Mittal, R., Liu, G., Polineni, S. P., Bencie, N., Yan, D. & Liu, X. Z., Feb 20 2019, In : Gene. 686, p. 49-55 7 p.

Research output: Contribution to journalReview article

Inner Ear
MicroRNAs
Hearing Loss
Inner Auditory Hair Cells
Research

The Generation of Zebrafish Mariner Model Using the CRISPR/Cas9 System

Zou, B., Desmidt, A. A., Mittal, R., Yan, D., Richmond, M., Tekin, M., Liu, X. & Lu, Z., Jan 1 2019, (Accepted/In press) In : Anatomical Record.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
nucleases
Zebrafish
Danio rerio
mutants
1 Citation (Scopus)

Zebrafish Model for Nonsyndromic X-Linked Sensorineural Deafness, DFNX1

DeSmidt, A. A., Zou, B., Grati, M., Yan, D., Mittal, R., Yao, Q., Richmond, M. T., Denyer, S., Liu, X. Z. & Lu, Z., Jan 1 2019, In : Anatomical Record.

Research output: Contribution to journalArticle

deafness
Ribose-Phosphate Pyrophosphokinase
Deafness
Zebrafish
Danio rerio
2018
4 Citations (Scopus)

A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss

Wang, L., Feng, Y., Yan, D., Qin, L., Grati, M., Mittal, R., Li, T., Sundhari, A. K., Liu, Y., Chapagain, P., Blanton, S. H., Liao, S. & Liu, X. Z., Jun 2 2018, (Accepted/In press) In : Human Genetics. p. 1-10 10 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Exome
Inner Auditory Hair Cells
Genes
Genetic Heterogeneity

Amino acid 118 in the deafness causing (DFNA20/26) ACTG1 gene is a mutational hot spot

Wang, L., Yan, D., Qin, L., Li, T., Liu, H., Li, W., Mittal, R., Yong, F., Chapagain, P., Liao, S. & Liu, X. Z., Jun 1 2018, In : Gene Reports. 11, p. 264-269 6 p.

Research output: Contribution to journalArticle

Deafness
Hearing Loss
Amino Acids
Genes
Mutation
3 Citations (Scopus)

A novel splicing mutation in SMPX is linked to nonsyndromic progressive hearing loss

Niu, Z., Yan, D., Bressler, S., Mei, L., Feng, Y. & Liu, X. Z., Jan 1 2018, In : International Journal of Pediatric Otorhinolaryngology. 104, p. 47-50 4 p.

Research output: Contribution to journalArticle

Hearing Loss
Exome
Mutation
Frameshift Mutation
Nonsense Codon
1 Citation (Scopus)

An update on phosphodiesterase mutations underlying genetic etiology of hearing loss and retinitis pigmentosa

Mittal, R., Bencie, N., Parrish, J. M., Liu, G., Mittal, J., Yan, D. & Liu, X. Z., Feb 8 2018, In : Frontiers in Genetics. 9, FEB, 9.

Research output: Contribution to journalComment/debate

Usher Syndromes
Retinitis Pigmentosa
Phosphoric Diester Hydrolases
Hearing Loss
Mutation
6 Citations (Scopus)

A possible association between hearing loss and Zika virus infections

Mittal, R., Fifer, R. & Liu, X. Z., Jan 1 2018, In : JAMA Otolaryngology - Head and Neck Surgery. 144, 1, p. 3-4 2 p.

Research output: Contribution to journalComment/debate

Hearing Loss
Zika Virus Infection
2 Citations (Scopus)

A xenograft model of vestibular schwannoma and hearing loss

Dinh, C. T., Bracho, O., Mei, C., Bas Infante, E., Fernandez-Valle, C., Telischi, F. F. & Liu, X. Z., Jun 1 2018, In : Otology and Neurotology. 39, 5, p. e362-e369

Research output: Contribution to journalArticle

Acoustic Neuroma
Hearing Loss
Heterografts
Neoplasms
Vestibulocochlear Nerve
3 Citations (Scopus)

ELMOD3, a novel causative gene, associated with human autosomal dominant nonsyndromic and progressive hearing loss

Li, W., Sun, J., Ling, J., Li, J., He, C., Liu, Y., Chen, H., Men, M., Niu, Z., Deng, Y., Li, M., Li, T., Wen, J., Sang, S., Li, H., Wan, Z., Richard, E. M., Chapagain, P., Yan, D., Liu, X. Z. & 2 others, Mei, L. & Feng, Y., Apr 1 2018, In : Human Genetics. 137, 4, p. 329-342 14 p.

Research output: Contribution to journalArticle

Genes
Hearing
Cell Movement
Exome
GTPase-Activating Proteins
3 Citations (Scopus)

First locally acquired congenital zika syndrome case in the United States: Neonatal clinical manifestations

Ventura, C. V., Bandstra, E. S., Fernandez, M. P., Cooper, J. M., Saigal, G., Bauer, C. R., Hofheimer, J. A., Berkovits, M., Fifer, R., Pensirikul, A., Gonzalez, I., Curry, C., Andreansky, S., Younis, R. T., Liu, X. Z., Banker, T., Dubovy, S., Langer, S. M. & Berrocal, A., Sep 1 2018, In : Ophthalmic Surgery Lasers and Imaging Retina. 49, 9, p. e93-e98

Research output: Contribution to journalArticle

Neutralization Tests
Microcephaly
First Pregnancy Trimester
Nerve Fibers
Nausea

Fluorescent detection of Merlin-deficient Schwann cells and primary human vestibular schwannoma cells using sodium fluorescein

Perez, E. R., Bracho, O., Ein, L., Szczupak, M., Monje, P. V., Fernandez-Valle, C., Alshaiji, A., Ivan, M., Morcos, J., Liu, X. Z., Hoffer, M. E., Eshraghi, A., Angeli, S. I., Telischi, F. F. & Dinh, C. T., Jan 1 2018, In : Otology and Neurotology. 39, 8, p. 1053-1059 7 p.

Research output: Contribution to journalArticle

Neurofibromin 2
Acoustic Neuroma
Schwann Cells
Fluorescein
Fluorescence
3 Citations (Scopus)

Genetic basis of hearing loss in Spanish, Hispanic and Latino populations

Mittal, R., Patel, A. P., Nguyen, D., Pan, D. R., Jhaveri, V. M., Rudman, J. R., Dharmaraja, A., Yan, D., Feng, Y., Chapagain, P., Lee, D. J., Blanton, S. H. & Liu, X. Z., Mar 20 2018, In : Gene. 647, p. 297-305 9 p.

Research output: Contribution to journalReview article

Hearing Loss
Hispanic Americans
Population
Genes
Genetic Predisposition to Disease
2 Citations (Scopus)

Otosclerosis: From Genetics to Molecular Biology

Babcock, T. A. & Liu, X. Z., Apr 1 2018, In : Otolaryngologic Clinics of North America. 51, 2, p. 305-318 14 p.

Research output: Contribution to journalReview article

Otosclerosis
Molecular Biology
Genetic Research
Molecular Evolution
Bone Remodeling
4 Citations (Scopus)

Precision medicine in hearing loss

Rudman, J. R., Mei, C., Bressler, S. E., Blanton, S. H. & Liu, X. Z., Jan 1 2018, (Accepted/In press) In : Journal of Genetics and Genomics.

Research output: Contribution to journalArticle

Precision Medicine
Hearing Loss
Electronic Health Records
Genomics
Hearing
5 Citations (Scopus)

Targeted Next-Generation Sequencing of a Deafness Gene Panel (MiamiOtoGenes) Analysis in Families Unsuitable for Linkage Analysis

Shang, H., Yan, D., Tayebi, N., Saeidi, K., Sahebalzamani, A., Feng, Y., Blanton, S. H. & Liu, X. Z., Jan 1 2018, In : BioMed Research International. 2018, 3103986.

Research output: Contribution to journalArticle

Deafness
Genes
Audition
Sensation Disorders
Recessive Genes
2017
7 Citations (Scopus)

A novel frameshift mutation of SMPX causes a rare form of X-linked nonsyndromic hearing loss in a Chinese family

Niu, Z., Feng, Y., Mei, L., Sun, J., Wang, X., Wang, J., Hu, Z., Dong, Y., Chen, H., He, C., Liu, Y., Cai, X., Liu, X. Z. & Jiang, L., May 1 2017, In : PLoS One. 12, 5, e0178384.

Research output: Contribution to journalArticle

frameshift mutation
Frameshift Mutation
Audition
hearing
Hearing Loss
5 Citations (Scopus)

Combination therapy with c-Met and Src inhibitors induces caspase-dependent apoptosis of merlin-deficient Schwann cells and suppresses growth of schwannoma cells

Fuse, M. A., Plati, S. K., Burns, S. S., Dinh, C. T., Bracho, O., Yan, D., Mittal, R., Shen, R., Soulakova, J. N., Copik, A. J., Liu, X. Z., Telischi, F. F., Chang, L. S., Franco, M. C. & Fernandez-Valle, C., Nov 1 2017, In : Molecular Cancer Therapeutics. 16, 11, p. 2387-2398 12 p.

Research output: Contribution to journalArticle

Neurofibromin 2
Neurofibromatosis 2
Caspase Inhibitors
Schwann Cells
Neurilemmoma
Quorum Sensing
Pseudomonas aeruginosa
Virulence
Serotonin
Emotions
5 Citations (Scopus)
Noise
Rehabilitation
Technology
Bone and Bones
Sensorineural Hearing Loss
1 Citation (Scopus)

Exome sequencing identifies a novel missense mutation of WFS1 as the cause of non-syndromic low-frequency hearing loss in a Chinese family

Niu, Z., Feng, Y., Hu, Z., Li, J., Sun, J., Chen, H., He, C., Wang, X., Jiang, L., Liu, Y., Cai, X., Wang, L., Cai, Y., Liu, X. Z. & Mei, L., Sep 1 2017, In : International Journal of Pediatric Otorhinolaryngology. 100, p. 1-7 7 p.

Research output: Contribution to journalArticle

Exome
Sensorineural Hearing Loss
Missense Mutation
Pedigree
Hearing Loss
9 Citations (Scopus)

Exome sequencing identifies POU4F3 as the causative gene for a large Chinese family with non-syndromic hearing loss

Cai, X. Z., Li, Y., Xia, L., Peng, Y., He, C. F., Jiang, L., Feng, Y., Xia, K., Liu, X. Z., Mei, L. Y. & Hu, Z. M., Feb 1 2017, In : Journal of Human Genetics. 62, 2, p. 317-320 4 p.

Research output: Contribution to journalArticle

Exome
Hearing Loss
Deafness
Genes
Sensation Disorders

Genetic screening revealed usher syndrome in a paediatric Chinese patient

Qu, C., Liang, F., Long, Q., Zhao, M., Shang, H., Fan, L., Wang, L., Yan, D. & Liu, X. Z., Apr 3 2017, In : Hearing, Balance and Communication. 15, 2, p. 98-106 9 p.

Research output: Contribution to journalArticle

Usher Syndromes
Genetic Testing
Hearing Loss
Pediatrics
Missense Mutation
59 Citations (Scopus)

Neurotransmitters: The Critical Modulators Regulating Gut–Brain Axis

Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Patel, K., O'Connor, G., Grati, M., Mittal, J., Yan, D., Eshraghi, A., Deo, S. K., Daunert, S. & Liu, X. Z., Sep 1 2017, In : Journal of Cellular Physiology. 232, 9, p. 2359-2372 14 p.

Research output: Contribution to journalReview article

Modulators
Neurotransmitter Agents
Physiology
Catecholamines
Serotonin
7 Citations (Scopus)

Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells

Petrilli, A. M., Garcia, J., Bott, M., Plati, S. K., Dinh, C. T., Bracho, O. R., Yan, D., Zou, B., Mittal, R., Telischi, F. F., Liu, X. Z., Chang, L. S., Welling, D. B., Copik, A. J. & Fernández-Valle, C., 2017, In : Oncotarget. 8, 19, p. 31666-31681 16 p.

Research output: Contribution to journalArticle

Neurofibromatosis 2
G1 Phase Cell Cycle Checkpoints
Neurofibromin 2
Schwann Cells
Platelet-Derived Growth Factor Receptors
20 Citations (Scopus)

Recent advancements in the regeneration of auditory hair cells and hearing restoration

Mittal, R., Nguyen, D., Patel, A. P., Debs, L. H., Mittal, J., Yan, D., Eshraghi, A., Van De Water, T. R. & Liu, X. Z., Jul 31 2017, In : Frontiers in Molecular Neuroscience. 10, 236.

Research output: Contribution to journalReview article

Auditory Hair Cells
Hearing
Regeneration
Hearing Loss
Neuroepithelial Cells
1 Citation (Scopus)

Role of cyclic nucleotide phosphodiesterases in inner ear and hearing

Mittal, R., Bencie, N., Shaikh, N., Mittal, J., Liu, X. Z. & Eshraghi, A., Nov 9 2017, In : Frontiers in Physiology. 8, NOV, 908.

Research output: Contribution to journalComment/debate

Cyclic Nucleotides
Phosphoric Diester Hydrolases
Inner Ear
Hearing
12 Citations (Scopus)

Screening of deafness-causing DNA variants that are common in patients of European ancestry using a microarray-based approach

Yan, D., Xiang, G., Chai, X., Qing, J., Shang, H., Mittal, B. Z. R., Shen, J., Smith, R. J. H., Fan, Y-S., Blanton, S. H., Tekin, M., Morton, C., Xing, W., Cheng, J. & Liu, X. Z., Mar 1 2017, In : PLoS One. 12, 3, e0169219.

Research output: Contribution to journalArticle

deafness
Audition
hearing
Deafness
Microarrays
4 Citations (Scopus)

Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function

Mittal, R., Debs, L. H., Nguyen, D., Patel, A. P., Grati, M., Mittal, J., Yan, D., Eshraghi, A. & Liu, X. Z., 2017, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Audition
Hearing
Regeneration
Cells
Ear
4 Citations (Scopus)

The advances in hearing rehabilitation and cochlear implants in China

Li, J. N., Chen, S., Zhai, L., Han, D. Y., Eshraghi, A., Feng, Y., Yang, S. M. & Liu, X. Z., Jan 1 2017, In : Ear and Hearing. 38, 6, p. 647-652 6 p.

Research output: Contribution to journalArticle

Cochlear Implants
Hearing
China
Rehabilitation
Cochlear Implantation
14 Citations (Scopus)

Zika virus: An emerging global health threat

Mittal, R., Nguyen, D., Debs, L. H., Patel, A. P., Liu, G., Jhaveri, V. M., Kay, S. I. S., Mittal, J., Bandstra, E. S., Younis, R. T., Chapagain, P., Jayaweera, D. T. & Liu, X. Z., Dec 8 2017, In : Frontiers in cellular and infection microbiology. 7, DEC, 486.

Research output: Contribution to journalReview article

Rubella virus
Central America
Microcephaly
South America
Aedes
2016

Abnormal mRNA splicing but normal auditory brainstem response (ABR) in mice with the prestin (SLC26A5) IVS2-2A > G mutation

Zhang, J., Liu, Z., Chang, A., Fang, J., Men, Y., Tian, Y., Ouyang, X., Yan, D., Zhang, A., Sun, X., Tang, J., Liu, X. Z., Zuo, J. & Gao, J., Aug 1 2016, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 790, p. 1-7 7 p.

Research output: Contribution to journalArticle

Brain Stem Auditory Evoked Potentials
Messenger RNA
Mutation
Deafness
Hearing
9 Citations (Scopus)

A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60

Ben Said, M., Grati, M., Ishimoto, T., Zou, B., Chakchouk, I., Ma, Q., Yao, Q., Hammami, B., Yan, D., Mittal, R., Nakamichi, N., Ghorbel, A., Neng, L., Tekin, M., Shi, X. R., Kato, Y., Masmoudi, S., Lu, Z., Hmani, M. & Liu, X. Z., May 1 2016, In : Human Genetics. 135, 5, p. 513-524 12 p.

Research output: Contribution to journalArticle

Cochlea
Hearing Loss
Endothelium
Cations
Mutation
20 Citations (Scopus)

A next-generation sequencing gene panel (MiamiOtoGenes) for comprehensive analysis of deafness genes

Tekin, D., Yan, D., Bademci, G., Feng, Y., Guo, S., Foster, J., Blanton, S. H., Tekin, M. & Liu, X. Z., Mar 1 2016, In : Hearing Research. 333, p. 179-184 6 p.

Research output: Contribution to journalArticle

Deafness
Hearing Loss
Genes
Exons
Databases
4 Citations (Scopus)

Characterization of ATPase activity of P2RX2 cation channel

Mittal, R., Grati, M., Sedlacek, M., Yuan, F., Chang, Q., Yan, D., Lin, X., Kachar, B., Farooq, A., Chapagain, P., Zhang, Y. & Liu, X. Z., 2016, In : Frontiers in Physiology. 7, MAY, 186.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Cations
Adenosine Triphosphate
Ion Channel Gating
Hydrolysis
8 Citations (Scopus)
Unilateral Hearing Loss
Hearing Aids
Noise
Bone and Bones
Hearing
13 Citations (Scopus)

CRISPR: a versatile tool for both forward and reverse genetics research

Gurumurthy, C. B., Grati, M., Ohtsuka, M., Schilit, S. L. P., Quadros, R. M. & Liu, X. Z., Sep 1 2016, In : Human Genetics. 135, 9, p. 971-976 6 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Reverse Genetics
Genetic Research
Medical Genetics
Mutation
6 Citations (Scopus)

Functional characterization of a novel loss-of-function mutation of PRPS1 related to early-onset progressive nonsyndromic hearing loss in Koreans (DFNX1): Potential implications on future therapeutic intervention

Kim, S. Y., Kim, A. R., Kim, N. K. D., Lee, C., Han, J. H., Kim, M. Y., Jeon, E. H., Park, W. Y., Mittal, R., Yan, D., Liu, X. Z. & Choi, B. Y., Nov 1 2016, In : Journal of Gene Medicine. 18, 11-12, p. 353-358 6 p.

Research output: Contribution to journalArticle

Ribose-Phosphate Pyrophosphokinase
Sensorineural Hearing Loss
Mutation
Genetic Testing
Therapeutics
11 Citations (Scopus)

Hearing Assessment in Zebrafish during the First Week Postfertilization

Yao, Q., Desmidt, A. A., Tekin, M., Liu, X. Z. & Lu, Z., Apr 1 2016, In : Zebrafish. 13, 2, p. 79-86 8 p.

Research output: Contribution to journalArticle

hearing
Zebrafish
Danio rerio
Hearing
Otolithic Membrane
17 Citations (Scopus)

Indispensable Role of Ion Channels and Transporters in the Auditory System

Mittal, R., Aranke, M., Debs, L. H., Nguyen, D., Patel, A. P., Grati, M., Mittal, J., Yan, D., Chapagain, P., Eshraghi, A. & Liu, X. Z., 2016, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Audition
Endolymph
Ion Channels
Ear
Meniere Disease