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William K Scott, PhD

Professor

  • 12970 Citations
1990 …2018
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Personal profile

Research interests

Self Communities: none at present; Countries: Argentina and West Africa; Experience working on studies of tuberculosis in communities; Diverse Groups Worked With (USA): African-American individuals in North and South Carolina, Hispanic/Latino individuals in NC, SC, and Amish communities in Indiana and Ohio

Keywords

  • and infectious diseases
  • traits of aging
  • ophthalmological
  • Influence of genetic and environmental factors on age-related
  • neurodegenerative

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  • 21 Similar Profiles
Macular Degeneration Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Single Nucleotide Polymorphism Medicine & Life Sciences
Genes Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Amish Medicine & Life Sciences
Genome-Wide Association Study Medicine & Life Sciences
Age of Onset Medicine & Life Sciences

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Projects 1990 2018

University of Miami Computational Ocular Genomics Training Program

Scott, W. K.

National Institutes of Health

1/1/13 → 12/31/18

Project: Research project › Institutional National Research Service Award

Genomics
Education
Research Personnel
Medical Genetics
National Institute of General Medical Sciences (U.S.)

Genetics of Parkinsonism

Scott, W. K., Beecham, G. W., Vance, J. M., Wahlestedt, C. R., Wahlestedt, C. R., Dykxhoorn, D. M., Wahlestedt, C. R. & Dykxhoorn, D. M.

National Institutes of Health

9/15/10 → 8/31/18

Project: Research project › Specialized Center

Parkinson Disease
Exome
Parkinsonian Disorders
Genes
Inborn Genetic Diseases

Genetic Studies of Successful Aging in the Amish

Scott, W. K.

National Institutes of Health

7/1/03 → 4/30/10

Project: Research project › Research Project

Amish
Genes
Disease Susceptibility
Health
Medical Genetics

Genetic Studies of Human Susceptibility to Tuberculosis

Scott, W. K.

National Institutes of Health

9/10/01 → 7/31/07

Project: Research project › Research Project

Medical Genetics
Tuberculosis
Genes
Mycobacterium tuberculosis
Multifactor Dimensionality Reduction

UNIFYING GENETICS EPIDEMIOLOGY OF MACULAR DEGENERATION

Scott, W. K., Pericak-Vance, M. A., Pericak-vance, M., Agarwal, A., Haines, J. L. & Pericak-vance, M. A.

National Institutes of Health

6/15/00 → 7/31/16

Project: Research project › Cooperative Clinical Research--Cooperative Agreements, Research Project

Progression
Gene
Etiology
Health
Environmental risk

Research Output 1994 2018

1 Citations

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Gharahkhani, P., Burdon, K. P., Cooke Bailey, J. N., Hewitt, A. W., Law, M. H., Pasquale, L. R., Kang, J. H., Haines, J. L., Souzeau, E., Zhou, T., Siggs, O. M., Landers, J., Awadalla, M., Sharma, S., Mills, R. A., Ridge, B., Lynn, D., Casson, R., Graham, S. L., Goldberg, I. & 45 othersWhite, A., Healey, P. R., Grigg, J., Lawlor, M., Mitchell, P., Ruddle, J., Coote, M., Walland, M., Best, S., Vincent, A., Gale, J., Radfordsmith, G., Whiteman, D. C., Montgomery, G. W., Martin, N. G., MacKey, D. A., Wiggs, J. L., MacGregor, S., Craig, J. E., Allingham, R. R., Brilliant, M., Budenz, D. L., Fingert, J. H., Gaasterland, D., Gaasterland, T., Hark, L., Hauser, M., Igo, R. P., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Moroi, S., Pericak-Vance, M. A., Realini, A., Rhee, D., Richards, J. E., Ritch, R., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Wollstein, G. & Zack, D. J., Dec 1 2018, In : Scientific Reports. 8, 1, 3124.

Research output: Contribution to journal › Article

Open Angle Glaucoma
Glaucoma
Genome-Wide Association Study
Eye Diseases
Chromosome Mapping

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Iglesias, A. I., Mishra, A., Vitart, V., Bykhovskaya, Y., Höhn, R., Springelkamp, H., Cuellar-Partida, G., Gharahkhani, P., Bailey, J. N. C., Willoughby, C. E., Li, X., Yazar, S., Nag, A., Khawaja, A. P., Polašek, O., Siscovick, D., Mitchell, P., Tham, Y. C., Haines, J. L., Kearns, L. S. & 124 othersHayward, C., Shi, Y., Van Leeuwen, E. M., Taylor, K. D., Wang, J. J., Rochtchina, E., Attia, J., Scott, R., Holliday, E. G., Baird, P. N., Xie, J., Inouye, M., Viswanathan, A., Sim, X., Bonnemaijer, P., Rotter, J. I., Martin, N. G., Zeller, T., Mills, R. A., Staffieri, S. E., Jonas, J. B., Schmidtmann, I., Boutin, T., Kang, J. H., Lucas, S. E. M., Wong, T. Y., Beutel, M. E., Wilson, J. F., Allingham, R. R., Brilliant, M. H., Budenz, D. L., Christen, W. G., Fingert, J., Friedman, D. S., Gaasterland, D., Gaasterland, T., Hauser, M. A., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Loomis, S. J., Moroi, S. E., Pericak-Vance, M. A., Realini, A., Richards, J. E., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Weinreb, R. N., Wollstein, G., Zack, D. J., Zhang, K., Donnelly, P., Barroso, I., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Deloukas, P., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Wood, N. W., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Pearson, R., Strange, A., Su, Z., Vukcevic, D., Langford, C., Hunt, S. E., Edkins, S., Gwilliam, R., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P., Uitterlinden, A. G., Vithana, E. N., Foster, P. J., Hysi, P. G., Hewitt, A. W., Khor, C. C., Pasquale, L. R., Montgomery, G. W., Klaver, C. C. W., Aung, T., Pfeiffer, N., MacKey, D. A., Hammond, C. J., Cheng, C. Y., Craig, J. E., Rabinowitz, Y. S., Wiggs, J. L., Burdon, K. P., Van Duijn, C. M. & MacGregor, S., Dec 1 2018, In : Nature communications. 9, 1, 1864.

Research output: Contribution to journal › Article

eye diseases
Eye Diseases
genome
Genome-Wide Association Study
Keratoconus

Family-based genome-wide association study of south Indian pedigrees supports WNT7B as a central corneal thickness locus

Fan, B. J., Chen, X., Sondhi, N., Sharmila, P. F., Soumittra, N., Sripriya, S., Sacikala, S., Asokan, R., Friedman, D. S., Pasquale, L. R., Gao, X. R., Vijaya, L., Bailey, J. C., Vitart, V., Macgregor, S., Hammond, C. J., Khor, C. C., Haines, J. L., George, R., Wiggs, J. L. & 70 othersAllingham, R. R., Gao, X. R., Gauderman, J., Hauser, M., Rotter, J. I., Varma, R., Wiggs, J., Aung, T., Burdon, K. P., Cheng, C. Y., Craig, J. E., Cree, A. J., Gharahkhani, P., Hewitt, A. W., Höhn, R., Hysi, P., Iglesias Gonzalez, A. I., Jonas, J., Khawaja, A., Khor, C. C., Klaver, C. C. W., Pasutto, F., Macgregor, S., Mackey, D., Mitchell, P., Mishra, A., Pang, C., Pasquale, L. R., Pasutto, F., Springelkamp, H., Thorleifsson, G., Thorsteinsdottir, U., van Duijn, C. M., Viswanathan, A., Vitart, V., Wiggs, J. L., Wojciechowski, R., Wong, T., Young, T. L., Zeller, T., Allingham, R., Brilliant, M., Budenz, D., Bailey, J. C., Fingert, J., Gaasterland, D., Gaasterland, T., Haines, J. L., Hauser, M., Igo, R., Kang, J. H., Kraft, P., Lee, R. K., Lichter, P., Liu, Y., Moroi, S., Pasquale, L. R., Realini, A., Rhee, D., Richards, J. R., Ritch, R., Schuman, J., Scott, W. K., Singh, K., Sit, A., Vollrath, D., Weinreb, R. N., Wiggs, J. L., Wollstein, G. & Zack, D., May 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 6, p. 2495-2502 8 p.

Research output: Contribution to journal › Article

Genome-Wide Association Study
Pedigree
Single Nucleotide Polymorphism
Hispanic Americans
Population
21 Citations

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease

Hui, K. Y., Fernandez-Hernandez, H., Hu, J., Schaffner, A., Pankratz, N., Hsu, N. Y., Chuang, L. S., Carmi, S., Villaverde, N., Li, X., Rivas, M., Levine, A. P., Bao, X., Labrias, P. R., Haritunians, T., Ruane, D., Gettler, K., Chen, E., Li, D., Schiff, E. R. & 31 othersPontikos, N., Barzilai, N., Brant, S. R., Bressman, S., Cheifetz, A. S., Clark, L. N., Daly, M. J., Desnick, R. J., Duerr, R. H., Katz, S., Lencz, T., Myers, R. H., Ostrer, H., Ozelius, L., Payami, H., Peter, Y., Rioux, J. D., Segal, A. W., Scott, W. K., Silverberg, M. S., Vance, J. M., Ubarretxena-Belandia, I., Foroud, T., Atzmon, G., Pe'er, I., Ioannou, Y., McGovern, D. P. B., Yue, Z., Schadt, E. E., Cho, J. H. & Peter, I., Jan 10 2018, In : Science Translational Medicine. 10, 423, eaai7795.

Research output: Contribution to journal › Article

Crohn Disease
Parkinson Disease
Genes
Phosphotransferases
Haplotypes
1 Citations

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

International Glaucoma Genetics Consortium & NEIGHBORHOOD Consortium, Jan 1 2018, In : PLoS Genetics. 14, 1, e1007145.

Research output: Contribution to journal › Article

glaucoma
Glaucoma
genomics
risk factor
Quantitative Trait Loci