Wei Li

Research Associate Professor

  • 965 Citations
1991 …2023
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1991 2019

2019

Anti-secretogranin III therapy of oxygen-induced retinopathy with optimal safety

Tang, F., LeBlanc, M. E., Wang, W., Liang, D., Chen, P., Chou, T. H., Tian, H. & Li, W., Jan 1 2019, (Accepted/In press) In : Angiogenesis.

Research output: Contribution to journalArticle

Retinopathy of Prematurity
Monoclonal Antibodies
Oxygen
Safety
Pathologic Neovascularization

Function-first ligandomics for ocular vascular research and drug target discovery

Rong, X., Tian, H., Yang, L. & Li, W., May 1 2019, In : Experimental Eye Research. 182, p. 57-64 8 p.

Research output: Contribution to journalShort survey

Drug Discovery
Blood Vessels
Research
Ligands
Vascular Endothelial Growth Factor A

Secretogranin III as a novel target for the therapy of choroidal neovascularization

LeBlanc, M. E., Wang, W., Ji, Y., Tian, H., Liu, D., Zhang, X. & Li, W., Apr 1 2019, In : Experimental Eye Research. 181, p. 120-126 7 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Monoclonal Antibodies
Neutralizing Antibodies
Vascular Endothelial Growth Factor A
Macular Degeneration
2018
5 Citations (Scopus)

Ligandomics: a paradigm shift in biological drug discovery

Li, W., Pang, I. H., Pacheco, M. T. F. & Tian, H., Mar 1 2018, In : Drug Discovery Today. 23, 3, p. 636-643 8 p.

Research output: Contribution to journalReview article

Drug Discovery
Biological Products
Ligands
Molecular Probes
Therapeutic Uses
4 Citations (Scopus)

Secretogranin III: a diabetic retinopathy-selective angiogenic factor

Li, W., Webster, K. A., LeBlanc, M. E. & Tian, H., Feb 1 2018, In : Cellular and Molecular Life Sciences. 75, 4, p. 635-647 13 p.

Research output: Contribution to journalReview article

Angiogenesis Inducing Agents
Diabetic Retinopathy
Secretory Vesicles
Pathologic Neovascularization
Retinal Neovascularization
8 Citations (Scopus)

Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway

Tang, F., Pacheco, M. T. F., Chen, P., Liang, D. & Li, W., Jan 1 2018, In : Biochemical and Biophysical Research Communications. 495, 1, p. 781-786 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
Endothelial cells
Human Umbilical Vein Endothelial Cells
Phosphorylation
2017
8 Citations (Scopus)

Dendritic cell-derived exosomes for cancer immunotherapy: Hope and challenges

Tian, H. & Li, W., 2017, In : Annals of Translational Medicine. 5, 10, 221.

Research output: Contribution to journalEditorial

6 Citations (Scopus)

Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease

Wang, W., LeBlanc, M. E., Chen, X., Chen, P., Ji, Y., Brewer, M., Tian, H., Spring, S. R., Webster, K. A. & Li, W., Apr 26 2017, (Accepted/In press) In : Angiogenesis. p. 1-14 14 p.

Research output: Contribution to journalArticle

Eye Diseases
Vascular Diseases
Diabetic Retinopathy
Retinopathy of Prematurity
Macular Degeneration
10 Citations (Scopus)

Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy

LeBlanc, M. E., Wang, W., Chen, X., Caberoy, N. B., Guo, F., Shen, C., Ji, Y., Tian, H., Wang, H., Chen, R. & Li, W., Apr 1 2017, In : Journal of Experimental Medicine. 214, 4, p. 1029-1047 19 p.

Research output: Contribution to journalArticle

Retinopathy of Prematurity
Diabetic Retinopathy
Retinal Neovascularization
Vascular Endothelial Growth Factor A
Retinal Vessels
2016
2 Citations (Scopus)

Mesd extrinsically promotes phagocytosis by retinal pigment epithelial cells

Chen, X., Guo, F., LeBlanc, M. E., Ding, Y., Zhang, C., Shakya, A. & Li, W., May 17 2016, (Accepted/In press) In : Cell Biology and Toxicology. p. 1-12 12 p.

Research output: Contribution to journalArticle

Retinal Pigments
Phagocytosis
Epithelial Cells
Cells
Endoplasmic Reticulum
5 Citations (Scopus)

The regulatory role of hepatoma-derived growth factor as an angiogenic factor in the eye

LeBlanc, M. E., Wang, W., Chen, X., Ji, Y., Shakya, A., Shen, C., Zhang, C., Gonzalez, V., Brewer, M., Ma, J. X., Wen, R., Zhang, F. & Li, W., Apr 23 2016, In : Molecular Vision. 22, p. 374-386 13 p.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
Retinal Vessels
hepatoma-derived growth factor
Retina
Permeability
2015
10 Citations (Scopus)

ABCF1 extrinsically regulates retinal pigment epithelial cell phagocytosis

Guo, F., Ding, Y., Caberoy, N., Alvarado, G., Wang, F., Chen, R. & Li, W., Jun 15 2015, In : Molecular Biology of the Cell. 26, 12, p. 2311-2320 10 p.

Research output: Contribution to journalArticle

Cytophagocytosis
Retinal Pigments
Adenosine Triphosphate
Epithelial Cells
Phagocytosis
9 Citations (Scopus)

Hepatoma-derived growth factor-related protein-3 is a novel angiogenic factor

LeBlanc, M. E., Wang, W., Caberoy, N. B., Chen, X., Guo, F., Alvarado, G., Shen, C., Wang, F., Wang, H., Chen, R., Liu, Z-J., Webster, K. A. & Li, W., May 21 2015, In : PLoS One. 10, 5, e0127904.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
hepatoma
growth factors
Endothelial cells
Assays
2 Citations (Scopus)

Lyar Is a New Ligand for Retinal Pigment Epithelial Phagocytosis

Guo, F., Ding, Y., Caberoy, N. B., Alvarado, G., Liu, R., Shen, C., Yu, J., Zhou, Y., Salero, E., Leblanc, M. E., Wang, W. & Li, W., Oct 1 2015, In : Journal of Cellular Biochemistry. 116, 10, p. 2177-2187 11 p.

Research output: Contribution to journalArticle

Retinal Pigments
Phagocytosis
Clone Cells
Ligands
Antibodies
6 Citations (Scopus)

Reticulocalbin-1 facilitates microglial phagocytosis

Ding, Y., Caberoy, N. B., Guo, F., LeBlanc, M. E., Zhang, C., Wang, W., Wang, F., Chen, R. & Li, W., May 18 2015, In : PLoS One. 10, 5, e0126993.

Research output: Contribution to journalArticle

phagocytosis
Phagocytosis
Ligands
Neurons
Cells
2013
43 Citations (Scopus)

Phagocyte dysfunction, tissue aging and degeneration

Li, W., Jun 1 2013, In : Ageing Research Reviews. 12, 4, p. 1005-1012 8 p.

Research output: Contribution to journalArticle

Phagocytes
Aging of materials
Tissue
Tissue homeostasis
Retinal Pigments
2012
35 Citations (Scopus)

Eat-me signals: Keys to molecular phagocyte biology and "Appetite" control

Li, W., Apr 1 2012, In : Journal of Cellular Physiology. 227, 4, p. 1291-1297 7 p.

Research output: Contribution to journalArticle

Tissue homeostasis
Molecular biology
Appetite
Phagocytes
Phagocytosis
71 Citations (Scopus)

Galectin-3 is a new MerTK-specific eat-me signal

Caberoy, N. B., Alvarado, G., Bigcas, J. L. & Li, W., Jan 1 2012, In : Journal of Cellular Physiology. 227, 2, p. 401-407 7 p.

Research output: Contribution to journalArticle

Galectin 3
Cloning
Phagocytosis
Organism Cloning
Cytophagocytosis
13 Citations (Scopus)

ORF phage display to identify cellular proteins with different functions

Li, W., Sep 1 2012, In : Methods. 58, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

Bacteriophages
Open Reading Frames
Display devices
Reading Frames
Gene Library
5 Citations (Scopus)

Sarcoidosis mimicking recurrent lymphoma

Li, W., Holdeman, K., Laurini, J. A., Bierman, P. J., Vose, J. M., Bociek, R. G. & Armitage, J. O., Jul 1 2012, In : American Journal of Hematology. 87, 7, p. 711-712 2 p.

Research output: Contribution to journalArticle

Local Neoplasm Recurrences
Lacrimal Apparatus Diseases
Lacrimal Apparatus
Hypercalcemia
B-Cell Lymphoma
19 Citations (Scopus)

Tubby regulates microglial phagocytosis through MerTK

Caberoy, N. B., Alvarado, G. & Li, W., Nov 14 2012, In : Journal of Neuroimmunology. 252, 1-2, p. 40-48 9 p.

Research output: Contribution to journalArticle

Phagocytosis
Cytophagocytosis
Microglia
Phagocytes
Ligands
2 Citations (Scopus)

Unraveling the molecular mystery of retinal pigment epithelium phagocytosis

Caberoy, N. B. & Li, W., Jan 23 2012, Advances in Experimental Medicine and Biology. Vol. 723. p. 693-699 7 p. (Advances in Experimental Medicine and Biology; vol. 723).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Retinal Pigments
Retinal Pigment Epithelium
Phagocytosis
Ligands
Molecular Probes
2011
7 Citations (Scopus)

Identification of calpain substrates by ORF phage display

Caberoy, N. B., Alvarado, G. & Li, W., Feb 1 2011, In : Molecules. 16, 2, p. 1739-1748 10 p.

Research output: Contribution to journalArticle

Bacteriophages
Calpain
Open Reading Frames
Display devices
protease
16 Citations (Scopus)

Identification of Hnrph3 as an autoantigen for acute anterior uveitis

Kim, Y., Caberoy, N. B., Alvarado, G., Davis, J. L., Feuer, W. J. & Li, W., Jan 1 2011, In : Clinical Immunology. 138, 1, p. 60-66 7 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoproteins
Anterior Uveitis
Autoantigens
Bacteriophages
Reading Frames
2010
33 Citations (Scopus)

Efficient identification of tubby-binding proteins by an improved system of T7 phage display

Caberoy, N. B., Zhou, Y., Jiang, X., Alvarado, G. & Li, W., Jan 1 2010, In : Journal of Molecular Recognition. 23, 1, p. 74-83 10 p.

Research output: Contribution to journalArticle

Bacteriophage T7
Bacteriophages
Carrier Proteins
Open Reading Frames
Proteins
34 Citations (Scopus)

Identification of tubby and tubby-like protein 1 as eat-me signals by phage display

Caberoy, N. B., Maiguel, D., Kim, Y. & Li, W., Jan 15 2010, In : Experimental Cell Research. 316, 2, p. 245-257 13 p.

Research output: Contribution to journalArticle

Bacteriophages
Phagocytosis
Retinal Pigment Epithelium
Proteins
Open Reading Frames
32 Citations (Scopus)

New perspective for phage display as an efficient and versatile technology of functional proteomics

Li, W. & Caberoy, N. B., Jan 1 2010, In : Applied Microbiology and Biotechnology. 85, 4, p. 909-919 11 p.

Research output: Contribution to journalArticle

Proteomics
Bacteriophages
Technology
Reading Frames
Open Reading Frames
87 Citations (Scopus)

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis

Caberoy, N. B., Zhou, Y. & Li, W., Dec 1 2010, In : EMBO Journal. 29, 23, p. 3898-3910 13 p.

Research output: Contribution to journalArticle

Phagocytosis
Ligands
Proteins
Phosphorylation
Myosin Type II
2009
18 Citations (Scopus)

Can phage display be used as a tool to functionally identify endogenous eat-me signals in phagocytosis?

Caberoy, N. B., Zhou, Y. & Li, W., Jul 1 2009, In : Journal of Biomolecular Screening. 14, 6, p. 653-661 9 p.

Research output: Contribution to journalArticle

Bacteriophages
Phagocytosis
Display devices
Phagocytes
Genes
24 Citations (Scopus)

Efficient identification of phosphatidylserine-binding proteins by ORF phage display

Caberoy, N. B., Zhou, Y., Alvarado, G., Fan, X. & Li, W., Aug 14 2009, In : Biochemical and Biophysical Research Communications. 386, 1, p. 197-201 5 p.

Research output: Contribution to journalArticle

Bacteriophages
Phosphatidylserines
Open Reading Frames
Carrier Proteins
Display devices
15 Citations (Scopus)

Unconventional secretion of tubby and tubby-like protein 1

Caberoy, N. B. & Li, W., Sep 17 2009, In : FEBS Letters. 583, 18, p. 3057-3062 6 p.

Research output: Contribution to journalArticle

Protein Sorting Signals
Proteins
Fibroblast Growth Factor 2
Phosphatidylinositols
Endoplasmic Reticulum
2008
1 Citation (Scopus)
Feline Immunodeficiency Virus
Transgenes
Stem Cells
Down-Regulation
Lentivirus
2006
9 Citations (Scopus)

Expression of K6W-ubiquitin inhibits proliferation of human lens epithelial cells

Liu, Q., Shang, F., Zhang, X., Li, W. & Taylor, A., Aug 16 2006, In : Molecular Vision. 12, p. 931-936 6 p.

Research output: Contribution to journalArticle

Ubiquitin
Lenses
Epithelial Cells
Proteasome Endopeptidase Complex
Cell Proliferation
36 Citations (Scopus)

Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells

Ouyang, J., Shen, Y. C., Yeh, L. K., Li, W., Coyle, B. M., Liu, C. Y. & Fini, M. E., Jun 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 6, p. 2397-2407 11 p.

Research output: Contribution to journalArticle

Cell Cycle
Epithelial Cells
Cell Proliferation
Doxycycline
Adenoviridae
8 Citations (Scopus)

Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphase

Liu, Q., Shang, F., Whitcomb, E., Guo, W., Li, W. & Taylor, A., Apr 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 4, p. 1302-1309 8 p.

Research output: Contribution to journalArticle

Ubiquitin-Conjugating Enzymes
Metaphase
Lenses
Cell Cycle
Epithelial Cells
2005
34 Citations (Scopus)

Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display

Zhang, Y., Davis, J. L. & Li, W., Jul 1 2005, In : Molecular Immunology. 42, 11, p. 1275-1281 7 p.

Research output: Contribution to journalArticle

Uveitis
Autoantigens
Bacteriophages
Immunoglobulin G
Far-Western Blotting
13 Citations (Scopus)

Synergistic antibody induction by antigen-CD40 ligand fusion protein as improved immunogen

Li, W., Jun 1 2005, In : Immunology. 115, 2, p. 215-222 8 p.

Research output: Contribution to journalArticle

CD40 Ligand
Antigens
Antibodies
Fluorescence
Proteins
2003
1 Citation (Scopus)

Differential T-cell activation by B7-1 expression

Li, W., Rosenzweig, A. & Huber, B. T., Jul 1 2003, In : Immunology. 109, 3, p. 336-342 7 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Adenoviridae
Viral Antigens
Peptides
CD80 Antigens
5 Citations (Scopus)

mRNA localization in polarized intestinal epithelial cells

Houle, V. M., Li, W., Montgomery, R. K. & Grand, R. J., Apr 1 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 284, 4 47-4

Research output: Contribution to journalArticle

Proxy
Epithelial Cells
Messenger RNA
Enterocytes
Oligo-1,6-Glucosidase
2002
37 Citations (Scopus)

Identification of two calcineurin B-binding proteins: Tubulin and heat shock protein 60

Li, W. & Handschumacher, R. E., Sep 23 2002, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1599, 1-2, p. 72-81 10 p.

Research output: Contribution to journalArticle

Chaperonin 60
Calcineurin
Tubulin
Carrier Proteins
Calmodulin
2001
17 Citations (Scopus)

Recombinant adenovirus coexpressing covalent peptide/MHC class II complex and B7-1: In vitro and in vivo activation of myelin basic protein-specific T cells

Chen, J., Huber, B. T., Grand, R. J. & Li, W., Aug 1 2001, In : Journal of Immunology. 167, 3, p. 1297-1305 9 p.

Research output: Contribution to journalArticle

Myelin Basic Protein
Adenoviridae
T-Lymphocytes
Peptides
B7 Antigens
2000
5 Citations (Scopus)

Brush border myosin I (BBMI): A basally localized transcript in human jejunal enterocytes

Li, W., Wang, J., Coluccio, L. M., Matsudaira, P. & Grand, R. J., Jan 2000, In : Journal of Histochemistry and Cytochemistry. 48, 1, p. 89-94 6 p.

Research output: Contribution to journalArticle

Myosin Type I
Enterocytes
Microvilli
Messenger RNA
3' Untranslated Regions
1999

Gene therapy for gastrointestinal disorders: Just around the corner?

Grand, R. J., Li, W., Montgomery, R. K. & Buller, H. A., 1999, In : Journal of Pediatric Gastroenterology and Nutrition. 29, 4, p. 375-376 2 p.

Research output: Contribution to journalShort survey

Gastrointestinal Diseases
Genetic Therapy
1998
15 Citations (Scopus)

Asymmetrical localization of mRNAs in enterocytes of human jejunum

Barth, J. A., Li, W., Krasinski, S. D., Montgomery, R. K., Verhave, M. & Grand, R. J., Mar 1998, In : Journal of Histochemistry and Cytochemistry. 46, 3, p. 335-343 9 p.

Research output: Contribution to journalArticle

Enterocytes
Jejunum
Messenger RNA
Lactase-Phlorizin Hydrolase
Oligo-1,6-Glucosidase
15 Citations (Scopus)

Three distinct messenger RNA distribution patterns in human jejunal enterocytes

Li, W., Krasinski, S. D., Verhave, M., Montgomery, R. K. & Grand, R. J., 1998, In : Gastroenterology. 115, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Enterocytes
Messenger RNA
Sodium-Glucose Transporter 1
RNA Transport
RNA Probes
1996

Alternative protein ligands of calcineurin b: Ca++dependent interaction with tubulin and heat shock protein 60

Li, W. & Handschumacher, R. E., 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Chaperonin 60
Calcineurin
Tubulin
tubulin
heat shock proteins
12 Citations (Scopus)

Regulation of the nuclear factor of activated T cells in stably transfected Jurkat cell clones

Li, W. & Handschumacher, R. E., Feb 6 1996, In : Biochemical and Biophysical Research Communications. 219, 1, p. 96-99 4 p.

Research output: Contribution to journalArticle

Clone cells
NFATC Transcription Factors
Jurkat Cells
Clone Cells
Chemical activation
1993
113 Citations (Scopus)

Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization

Kieffer, L. J., Seng, T. W., Li, W., Osterman, D. G., Handschumacher, R. E. & Bayney, R. M., 1993, In : Journal of Biological Chemistry. 268, 17, p. 12303-12310 8 p.

Research output: Contribution to journalArticle

Steroid Receptors
Cloning
Organism Cloning
Complementary DNA
Proteins
48 Citations (Scopus)

Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin

Li, W. & Handschumacher, R. E., 1993, In : Journal of Biological Chemistry. 268, 19, p. 14040-14044 5 p.

Research output: Contribution to journalArticle

Cyclophilins
Calcineurin
Cyclosporine
Calmodulin
Tacrolimus Binding Proteins
1992

Cysteamine selectively enhances neuropeptide Y2 receptor binding activity

Li, W. & Hexum, T. D., Apr 15 1992, In : Biochemical and Biophysical Research Communications. 184, 1, p. 380-386 7 p.

Research output: Contribution to journalArticle

Cysteamine
Labeling
Ethanolamine
Mercaptoethanol
Washing