W. Glenn Kerrick

2018

nNOS splice variants differentially regulate myofilament function but are dispensable for intracellular calcium and force transients in cardiac papillary muscles

Kerrick, G. W. L., Xu, Y. & Percival, J. M., Jul 1 2018, In : PLoS One. 13, 7, e0200834.

Research output: Contribution to journal › Article

Nitric Oxide Synthase Type I

Papillary Muscles

Myofibrils

myofibrils

myocardium

2017

10 Citations (Scopus)

GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity

Moon, Y., Cao, Y., Zhu, J., Xu, Y., Balkan, W. E., Buys, E. S., Diaz, F., Kerrick, W. G., Hare, J. & Percival, J., Feb 1 2017, In : Antioxidants and Redox Signaling. 26, 4, p. 165-181 17 p.

Research output: Contribution to journal › Article

Muscle Fatigue

Ryanodine Receptor Calcium Release Channel

Muscle Strength

Muscle

Skeletal Muscle

2009

24 Citations (Scopus)

Functional Effects of a Restrictive-Cardiomyopathy-Linked Cardiac Troponin I Mutation (R145W) in Transgenic Mice

Wen, Y., Xu, Y., Wang, Y., Pinto, J. R., Potter, J. D. & Kerrick, W. G., Oct 9 2009, In : Journal of Molecular Biology. 392, 5, p. 1158-1167 10 p.

Research output: Contribution to journal › Article

Restrictive Cardiomyopathy

Troponin I

Transgenic Mice

Adenosine Triphosphatases

Mutation

46 Citations (Scopus)

Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice

Kerrick, W. G., Kazmierczak, K., Xu, Y., Wang, Y. & Szczesna-Cordary, D., Mar 1 2009, In : FASEB Journal. 23, 3, p. 855-865 11 p.

Research output: Contribution to journal › Article

Familial Hypertrophic Cardiomyopathy

Ventricular Myosins

Myosin Light Chains

Papillary Muscles

Transgenic Mice

39 Citations (Scopus)

The Role of the N-Terminus of the Myosin Essential Light Chain in Cardiac Muscle Contraction

Kazmierczak, K., Xu, Y., Jones, M., Guzman, G., Hernandez, O. M., Kerrick, W. G. & Szczesna-Cordary, D., Apr 3 2009, In : Journal of Molecular Biology. 387, 3, p. 706-725 20 p.

Research output: Contribution to journal › Article

Myosin Light Chains

Myosins

Muscle Contraction

Myocardium

Transgenic Mice

2008

42 Citations (Scopus)

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

Wen, Y., Pinto, J. R., Gomes, A. V., Xu, Y., Wang, Y., Wang, Y., Potter, J. D. & Kerrick, W. G., Jul 18 2008, In : Journal of Biological Chemistry. 283, 29, p. 20484-20494 11 p.

Research output: Contribution to journal › Article

Troponin I

Hypertrophic Cardiomyopathy

Transgenic Mice

Adenosine Triphosphatases

Mutation

2007

30 Citations (Scopus)

Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients

Szczesna-Cordary, D., Jones, M., Moore, J. R., Watt, J., Kerrick, W. G., Xu, Y., Wang, Y., Wagg, C. & Lopaschuk, G. D., Dec 1 2007, In : FASEB Journal. 21, 14, p. 3974-3985 12 p.

Research output: Contribution to journal › Article

myosin light chains

Myosin Light Chains

Transgenic Mice

Muscle

Calcium

53 Citations (Scopus)

Triadins modulate intracellular Ca²⁺ homeostasis but are not essential for excitation-contraction coupling in skeletal muscle

Shen, X., Franzini-Armstrong, C., Lopez, J. R., Jones, L. R., Kobayashi, Y. M., Wang, Y., Kerrick, W. G., Caswell, A. H., Potter, J. D., Miller, T., Allen, P. D. & Perez, C. F., Dec 28 2007, In : Journal of Biological Chemistry. 282, 52, p. 37864-37874 11 p.

Research output: Contribution to journal › Article

Excitation Contraction Coupling

Muscle

Skeletal Muscle

Homeostasis

Sarcoplasmic Reticulum

2006

45 Citations (Scopus)

Prolonged Ca²⁺ and Force Transients in Myosin RLC Transgenic Mouse Fibers Expressing Malignant and Benign FHC Mutations

Wang, Y., Xu, Y., Kerrick, W. G., Wang, Y., Guzman, G., Diaz-Perez, Z. & Szczesna-Cordary, D., Aug 11 2006, In : Journal of Molecular Biology. 361, 2, p. 286-299 14 p.

Research output: Contribution to journal › Article

Familial Hypertrophic Cardiomyopathy

Myosin Light Chains

Transgenic Mice

Mutation

Calcium-Transporting ATPases

2005

23 Citations (Scopus)

Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform

Venkatraman, G., Gomes, A. V., Kerrick, W. G. & Potter, J. D., May 6 2005, In : Journal of Biological Chemistry. 280, 18, p. 17584-17592 9 p.

Research output: Contribution to journal › Article

Troponin T

Troponin

Dilated Cardiomyopathy

Protein Isoforms

Troponin C

50 Citations (Scopus)

F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers

Hernandez, O. M., Szczesna-Cordary, D., Knollmann, B. C., Miller, T., Bell, M., Zhao, J., Sirenko, S. G., Diaz, Z., Guzman, G., Xu, Y., Wang, Y., Kerrick, W. G. & Potter, J. D., Nov 4 2005, In : Journal of Biological Chemistry. 280, 44, p. 37183-37194 12 p.

Research output: Contribution to journal › Article

Familial Hypertrophic Cardiomyopathy

Troponin T

Muscle Contraction

Transgenic Mice

Muscle

2004

9 Citations (Scopus)

Inorganic phosphate affects the pCa-force relationship more than the pCa-ATPase by increasing the rate of dissociation of force generating cross-bridges in skinned fibers from both EDL and soleus muscles of the rat

Kerrick, W. G. & Xu, Y., Aug 24 2004, In : Journal of Muscle Research and Cell Motility. 25, 2, p. 107-117 11 p.

Research output: Contribution to journal › Article

Adenosine Triphosphatases

Muscle

Rats

Skeletal Muscle

Phosphates

2003

54 Citations (Scopus)

Different Functional Properties of Troponin T Mutants that Cause Dilated Cardiomyopathy

Venkatraman, G., Harada, K., Gomes, A. V., Kerrick, W. G. & Potter, J. D., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 41670-41676 7 p.

Research output: Contribution to journal › Article

Troponin T

Dilated Cardiomyopathy

Familial Hypertrophic Cardiomyopathy

Myosins

Mutation

2002

28 Citations (Scopus)

Activation of striated muscle: Nearest-neighbor regulatory-unit and cross-bridge influence on myofilament kinetics

Robinson, J. M., Wang, Y., Kerrick, W. G., Kawai, R. & Cheung, H. C., Nov 14 2002, In : Journal of Molecular Biology. 322, 5, p. 1065-1088 24 p.

Research output: Contribution to journal › Article

Striated Muscle

Myofibrils

Adenosine Triphosphatases

Muscles

Least-Squares Analysis

29 Citations (Scopus)

The off rate of Ca²⁺ from troponin C is regulated by force-generating cross bridges in skeletal muscle

Wang, Y. & Kerrick, W. G., Jul 2 2002, In : Journal of Applied Physiology. 92, 6, p. 2409-2418 10 p.

Research output: Contribution to journal › Article

Troponin C

Skeletal Muscle

Myosins

Vibration

Muscles

2001

89 Citations (Scopus)

Abnormal Contractile Function in Transgenic Mice Expressing a Familial Hypertrophic Cardiomyopathy-linked Troponin T (I79N) Mutation

Miller, T., Szczesna-Cordary, D., Housmans, P. R., Zhao, J., De Freitas, F., Gomes, A. V., Culbreath, L., McCue, J., Wang, Y., Xu, Y., Kerrick, W. G. & Potter, J. D., Feb 9 2001, In : Journal of Biological Chemistry. 276, 6, p. 3743-3755 13 p.

Research output: Contribution to journal › Article

Familial Hypertrophic Cardiomyopathy

Troponin T

Transgenic Mice

Adenosine Triphosphatases

Troponin C

2000

23 Citations (Scopus)

Ca²⁺ measurements in skinned cardiac fibers: Effects of Mg²⁺ on Ca²⁺ activation of force and fiber ATPase

Allen, K., Xu, Y. Y. & Kerrick, W. G., Jan 1 2000, In : Journal of Applied Physiology. 88, 1, p. 180-185 6 p.

Research output: Contribution to journal › Article

Adenosine Triphosphatases

Myosins

Troponin C

Muscle Contraction

Myocardium

1999

21 Citations (Scopus)

Troponin C regulates the rate constant for the dissociation of force-generating myosin cross-bridges in cardiac muscle

Wang, Y., Xu, Y., Guth, K. & Kerrick, W. G., Dec 1 1999, In : Journal of Muscle Research and Cell Motility. 20, 7, p. 645-653 9 p.

Research output: Contribution to journal › Article

Troponin C

Myosins

Muscle

Rate constants

Myocardium

1997

41 Citations (Scopus)

Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca²⁺-dependent events in vitro and in situ

Putkey, J. A., Liu, W., Lin, X., Ahmed, S., Zhang, M., Potter, J. D. & Kerrick, W. G., Jan 28 1997, In : Biochemistry. 36, 4, p. 970-978 9 p.

Research output: Contribution to journal › Article

Troponin C

Sulfonic Acids

Fluorescent Dyes

Myosins

Fluorescence

41 Citations (Scopus)

The effect of pH on the Ca²⁺ affinity of the Ca²⁺ regulatory sites of skeletal and cardiac troponin C in skinned muscle fibres

Parsons, B., Szczesna-Cordary, D., Zhao, J., Van Slooten, G., Kerrick, W. G., Putkey, J. A. & Potter, J. D., Oct 18 1997, In : Journal of Muscle Research and Cell Motility. 18, 5, p. 599-609 11 p.

Research output: Contribution to journal › Article

Troponin C

Muscle

Muscles

Fibers

Fluorescence

1994

8 Citations (Scopus)

Relationship between ATPase activity, Ca²⁺, and force in α-toxin- and β-escin-treated smooth muscle

Kerrick, W. G. & Hoar, P. E., Dec 1 1994, In : Canadian Journal of Physiology and Pharmacology. 72, 11, p. 1361-1367 7 p.

Research output: Contribution to journal › Article

Escin

Calcium-Transporting ATPases

Smooth Muscle

Adenosine Triphosphatases

Adenosine Triphosphate

1993

143 Citations (Scopus)

Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction

Bourguignon, L. Y. W., Lokeshwar, V. B., Chen, X. & Kerrick, W. G., Dec 15 1993, In : Journal of Immunology. 151, 12, p. 6634-6644 11 p.

Research output: Contribution to journal › Article

Hyaluronic Acid

Cytoskeleton

Signal Transduction

Lymphocytes

Ankyrins

10 Citations (Scopus)

Rapid stimulation of Ins(1,4,5)P₃ production in rat aorta by NE: Correlation with contractile state

Pijuan, V., Sukholutskaya, I., Kerrick, W. G., Lam, M., Van Breemen, C. & Litosch, I., Jan 1 1993, In : American Journal of Physiology - Heart and Circulatory Physiology. 264, 1 33-1

Research output: Contribution to journal › Article

Aorta

Norepinephrine

Inositol Phosphates

Inositol 1,4,5-Trisphosphate

Inositol

1992

Correspondence

Potter, J. D., Kerrick, W. G. & Gulati, J., Jun 1 1992, In : Journal of Muscle Research and Cell Motility. 13, 3, p. 381-382 2 p.

Research output: Contribution to journal › Article

Troponin C

Species Specificity

Strontium

Troponin

Muscle Contraction

13 Citations (Scopus)

Effects of the constitutively active proteolytic fragment of protein kinase C on the contractile properties of demembranated smooth muscle fibres

Parente, J. E., Walsh, M. P., Kerrick, W. G. & Hoar, P. E., Feb 1 1992, In : Journal of Muscle Research and Cell Motility. 13, 1, p. 90-99 10 p.

Research output: Contribution to journal › Article

Protein Kinase C

Smooth Muscle

Muscle

Phosphorylation

Myosins

1991

17 Citations (Scopus)

Functional characterization of the two isoforms of troponin C from the arthropod Balanus nubilus

Ashley, C. C., Lea, T. J., Hoar, P. E., Kerrick, W. G., Strang, P. F. & Potter, J. D., Dec 1 1991, In : Journal of Muscle Research and Cell Motility. 12, 6, p. 532-542 11 p.

Research output: Contribution to journal › Article

Thoracica

Troponin C

Arthropods

Protein Isoforms

Fibers

23 Citations (Scopus)

The apparent rate constant for the dissociation of force generating myosin crossbridges from actin decreases during Ca²⁺ activation of skinned muscle fibres

Kerrick, W. G., Potter, J. D. & Hoar, P. E., Feb 1 1991, In : Journal of Muscle Research and Cell Motility. 12, 1, p. 53-60 8 p.

Research output: Contribution to journal › Article

Myosins

Adenosine Triphosphatases

Muscle

Actins

Rate constants

1990

1 Citation (Scopus)

Effects of protein kinase-M on skinned smooth muscle fibres.

Parente, J. E., Walsh, M. P., Kerrick, W. G. & Hoar, P. E., Jan 1 1990, In : Progress in Clinical and Biological Research. 327, p. 149-157 9 p.

Research output: Contribution to journal › Article

Muscle Relaxation

Muscle Contraction

Protein Kinase C

Smooth Muscle

Chickens

2 Citations (Scopus)

Relationship between ATPase activity, isometric force, and myosin light chain phosphorylation and thiophosphorylation in skinned chicken gizzard fiber bundles.

Kerrick, W. G., Kenney, R. E. & Hoar, P. E., Jan 1 1990, In : Progress in Clinical and Biological Research. 327, p. 635-636 2 p.

Research output: Contribution to journal › Article

Avian Gizzard

Myosin Light Chains

Isometric Contraction

Myosins

Muscle Contraction

29 Citations (Scopus)

The relationship between ATPase activity, isometric force, and myosin light-chain phosphorylation and thiophosphorylation in skinned smooth muscle fiber bundles from chicken gizzard

Kenney, R. E., Hoar, P. E. & Kerrick, W. G., May 25 1990, In : Journal of Biological Chemistry. 265, 15, p. 8642-8649 8 p.

Research output: Contribution to journal › Article

Avian Gizzard

Myosin Light Chains

Phosphorylation

Smooth Muscle

Adenosine Triphosphatases

1989

23 Citations (Scopus)

The role of caldesmon in the regulation of receptor capping in mouse T-lymphoma cell

Walker, G., Kerrick, W. G. & Bourguignon, L. Y. W., Jan 1 1989, In : Journal of Biological Chemistry. 264, 1, p. 496-500 5 p.

Research output: Contribution to journal › Article

Receptor Aggregation

Calmodulin-Binding Proteins

T-Cell Lymphoma

Lymphoma

Peptides

1988

16 Citations (Scopus)

Mn²⁺ activates skinned smooth muscle cells in the absence of myosin light chain phosphorylation

Hoar, P. E. & Kerrick, W. G., Aug 1 1988, In : Pflügers Archiv European Journal of Physiology. 412, 3, p. 225-230 6 p.

Research output: Contribution to journal › Article

Myosin Light Chains

Phosphorylation

Dithiothreitol

Smooth Muscle Myocytes

Muscle

14 Citations (Scopus)

Skinned ventricular fibres: troponin C extraction is species-dependent and its replacement with skeletal troponin C changes Sr²⁺ activation properties

Hoar, P. E., Potter, J. D. & Kerrick, W. G., Apr 1 1988, In : Journal of Muscle Research and Cell Motility. 9, 2, p. 165-173 9 p.

Research output: Contribution to journal › Article

Troponin C

Chemical activation

Fibers

Rabbits

Rats

1987

35 Citations (Scopus)

MgADP^- increases maximum tension and Ca²⁺ sensitivity in skinned rabbit soleus fibers

Hoar, P. E., Mahoney, C. W., Kerrick, W. G. & Montague, D., Sep 1 1987, In : Pflügers Archiv European Journal of Physiology. 410, 1-2, p. 30-36 7 p.

Research output: Contribution to journal › Article

Adenosine Diphosphate

Rabbits

Fibers

Diphosphates

Nucleosides

5 Citations (Scopus)

Non-Ca2+-activated contraction in smooth muscle.

Kerrick, W. G. & Hoar, P. E., Dec 1 1987, In : Progress in Clinical and Biological Research. 245, p. 437-448 12 p.

Research output: Contribution to journal › Article

Cytidine Triphosphate

Myosins

Muscle Contraction

Adenosine Diphosphate

Magnesium

1986

2 Citations (Scopus)

Smooth muscle: regulation by calcium and phosphorylation.

Kerrick, W. G. & Hoar, P. E., Dec 1 1986, In : Ciba Foundation symposium. 122, p. 183-196 14 p.

Research output: Contribution to journal › Article

Smooth Muscle

Phosphorylation

Calcium

Myosin Light Chains

Smooth Muscle Myocytes

1985

23 Citations (Scopus)

Evidence that the Sr²⁺ activation properties of cardiac troponin C are altered when substituted into skinned skeletal muscle fibers

Kerrick, W. G., Zot, H. G., Hoar, P. E. & Potter, J. D., Dec 1 1985, In : Journal of Biological Chemistry. 260, 29, p. 15687-15693 7 p.

Research output: Contribution to journal › Article

Troponin C

Myosin Subfragments

Strontium

Troponin

Skeletal Muscle Fibers

24 Citations (Scopus)

Myosin light chain phosphatase. Effect on the activation and relaxation of gizzard smooth muscle skinned fibers

Hoar, P. E., Pato, M. D. & Kerrick, W. G., Dec 1 1985, In : Journal of Biological Chemistry. 260, 15, p. 8760-8764 5 p.

Research output: Contribution to journal › Article

Myosin-Light-Chain Phosphatase

Myosin-Light-Chain Kinase

Cytidine Triphosphate

Phosphorylation

Muscle Relaxation

1984

1 Citation (Scopus)

Effects of diethyl ether and nitrous oxide on functionally skinned myocardial cells of rabbits

Su, J. Y., Kerrick, W. G. & Hill, S. A., Jan 1 1984, In : Anesthesia and Analgesia. 63, 4, p. 451-456 6 p.

Research output: Contribution to journal › Article

Nitrous Oxide

Sarcoplasmic Reticulum

Ether

Rabbits

Papillary Muscles

28 Citations (Scopus)

Regulation of receptor capping in mouse lymphoma T cells by Ca²⁺-activated myosin light chain kinase

Kerrick, W. G. & Bourguignon, L. Y. W., Jan 1 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 1 I, p. 165-169 5 p.

Research output: Contribution to journal › Article

Receptor Aggregation

Myosin-Light-Chain Kinase

T-Cell Lymphoma

Smooth Muscle

Lymphocytes

1983

26 Citations (Scopus)

Gizzard Ca²⁺-independent myosin light chain kinase: Evidence in favor of the phosphorylation theory

Walsh, M. P., Bridenbaugh, R., Kerrick, W. G. & Hartshorne, D. J., Jan 1 1983, In : Federation Proceedings. 42, 1, p. 45-50 6 p.

Research output: Contribution to journal › Article

Avian Gizzard

Myosin-Light-Chain Kinase

Myosins

Phosphorylation

Actomyosin

7 Citations (Scopus)

Receptor capping in mouse T-lymphoma cells: A Ca²⁺ and calmodulin-stimulated ATP-dependent process

Bourguignon, L. Y. W. & Kerrick, W. G., Feb 1 1983, In : The Journal of Membrane Biology. 75, 1, p. 65-72 8 p.

Research output: Contribution to journal › Article

Receptor Aggregation

T-Cell Lymphoma

Calmodulin

Adenosine Triphosphate

Suspensions

1982

3 Citations (Scopus)

Capping of T-lymphoma cells: A Ca²⁺ and calmodulin stimulated ATP dependent process

Bourguignon, L. Y. W. & Kerrick, W. G., Dec 1 1982, In : Journal of Cell Biology. 95, 2 II

Research output: Contribution to journal › Article

T-Cell Lymphoma

Calmodulin

Adenosine Triphosphate

6 Citations (Scopus)

Evidence that myosin light chain phosphorylation regulates contraction in the body wall muscles of the sea cucumber

Kerrick, W. G. & Bolles, L. L., Jan 1 1982, In : Journal of Cellular Physiology. 112, 3, p. 307-315 9 p.

Research output: Contribution to journal › Article

Sea Cucumbers

Myosin Light Chains

Phosphorylation

Muscle

Myosin-Light-Chain Kinase

47 Citations (Scopus)

Phosphorylation-dependent activated tension in skinned gizzard muscle fibers in the absence of Ca2+.

Walsh, M. P., Bridenbaugh, R., Hartshorne, D. J. & Kerrick, W. G., Jun 10 1982, In : Journal of Biological Chemistry. 257, 11, p. 5987-5990 4 p.

Research output: Contribution to journal › Article

Myosin-Light-Chain Kinase

Phosphorylation

Muscle

Myosin Light Chains

Muscles

Regulation of the contractile apparatus in smooth muscle.

Harshorne, D. J., Walsh, M. P., Bridenbaugh, R. & Kerrick, W. G., Jan 1 1982, In : Proceedings of the Western Pharmacology Society. 25, p. 339-341 3 p.

Research output: Contribution to journal › Article

Myosin-Light-Chain Kinase

Muscle Contraction

Protein Kinases

Smooth Muscle

Chickens

18 Citations (Scopus)

Superprecipitation of gizzard actomyosin, and tension in gizzard muscle skinned fibers in the presence of nucleotides other than ATP

Cassidy, P. & Kerrick, W. G., Jul 12 1982, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 705, 1, p. 63-69 7 p.

Research output: Contribution to journal › Article

Inosine Triphosphate

Actomyosin

Guanosine Triphosphate

Smooth Muscle

Myosin-Light-Chain Kinase

1981

28 Citations (Scopus)

Calcium-regulatory mechanisms. Functional classification using skinned fibers

Kerrick, W. G., Hoar, P. E., Cassidy, P. S., Bolles, L. & Malencik, D. A., Dec 1 1981, In : Journal of General Physiology. 77, 2, p. 177-190 14 p.

Research output: Contribution to journal › Article

Pectinidae

Troponin I

Calmodulin

Adenosine

Troponin C

23 Citations (Scopus)

Exogenous calmodulin increases Ca²⁺ sensitivity of isometric tension activation and myosin phosphorylation in skinned smooth muscle

Cassidy, P. S., Kerrick, W. G., Hoar, P. E. & Malencik, D. A., Dec 1 1981, In : Pflügers Archiv European Journal of Physiology. 392, 2, p. 115-120 6 p.

Research output: Contribution to journal › Article

Phosphorylation

Calmodulin

Myosins

Smooth Muscle

Muscle

73 Citations (Scopus)

Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase

Kerrick, W. G. & Hoar, P. E., Dec 1 1981, In : Nature. 292, 5820, p. 253-255 3 p.

Research output: Contribution to journal › Article

Muscle Tonus

Cyclic AMP-Dependent Protein Kinases

Smooth Muscle

Muscle Contraction

Protein Kinases