W. Glenn Kerrick

2018

nNOS splice variants differentially regulate myofilament function but are dispensable for intracellular calcium and force transients in cardiac papillary muscles

Kerrick, G. W. L., Xu, Y. & Percival, J. M., Jul 2018, In : PloS one. 13, 7, e0200834.

Research output: Contribution to journal › Article

2017

GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity

Moon, Y., Cao, Y., Zhu, J., Xu, Y., Balkan, W. E., Buys, E. S., Diaz, F., Kerrick, W. G., Hare, J. & Percival, J., Feb 1 2017, In : Antioxidants and Redox Signaling. 26, 4, p. 165-181 17 p.

Research output: Contribution to journal › Article

11 Scopus citations

2009

Functional Effects of a Restrictive-Cardiomyopathy-Linked Cardiac Troponin I Mutation (R145W) in Transgenic Mice

Wen, Y., Xu, Y., Wang, Y., Pinto, J. R., Potter, J. D. & Kerrick, W. G. L., Oct 9 2009, In : Journal of molecular biology. 392, 5, p. 1158-1167 10 p.

Research output: Contribution to journal › Article

25 Scopus citations

Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice

Glenn L Kerrick, W., Kazmierczak, K., Xu, Y., Wang, Y. & Szczesna-Cordary, D., Mar 1 2009, In : FASEB Journal. 23, 3, p. 855-865 11 p.

Research output: Contribution to journal › Article

48 Scopus citations

The Role of the N-Terminus of the Myosin Essential Light Chain in Cardiac Muscle Contraction

Kazmierczak, K., Xu, Y., Jones, M., Guzman, G., Hernandez, O. M., Kerrick, W. G. L. & Szczesna-Cordary, D., Apr 3 2009, In : Journal of molecular biology. 387, 3, p. 706-725 20 p.

Research output: Contribution to journal › Article

40 Scopus citations

2008

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

Wen, Y., Pinto, J. R., Gomes, A. V., Xu, Y., Wang, Y., Wang, Y., Potter, J. D. & Kerrick, W. G. L., Jul 18 2008, In : Journal of Biological Chemistry. 283, 29, p. 20484-20494 11 p.

Research output: Contribution to journal › Article

44 Scopus citations

2007

Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients

Szczesna-Cordary, D., Jones, M., Moore, J. R., Watt, J., Kerrick, W. G. L., Xu, Y., Wang, Y., Wagg, C. & Lopaschuk, G. D., Dec 1 2007, In : FASEB Journal. 21, 14, p. 3974-3985 12 p.

Research output: Contribution to journal › Article

30 Scopus citations

Triadins modulate intracellular Ca²⁺ homeostasis but are not essential for excitation-contraction coupling in skeletal muscle

Shen, X., Franzini-Armstrong, C., Lopez, J. R., Jones, L. R., Kobayashi, Y. M., Wang, Y., Kerrick, W. G. L., Caswell, A. H., Potter, J. D., Miller, T., Allen, P. D. & Perez, C. F., Dec 28 2007, In : Journal of Biological Chemistry. 282, 52, p. 37864-37874 11 p.

Research output: Contribution to journal › Article

54 Scopus citations

2006

Prolonged Ca²⁺ and Force Transients in Myosin RLC Transgenic Mouse Fibers Expressing Malignant and Benign FHC Mutations

Wang, Y., Xu, Y., Kerrick, W. G. L., Wang, Y., Guzman, G., Diaz-Perez, Z. & Szczesna-Cordary, D., Aug 11 2006, In : Journal of molecular biology. 361, 2, p. 286-299 14 p.

Research output: Contribution to journal › Article

47 Scopus citations

2005

Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform

Venkatraman, G., Gomes, A. V., Kerrick, W. G. L. & Potter, J. D., May 6 2005, In : Journal of Biological Chemistry. 280, 18, p. 17584-17592 9 p.

Research output: Contribution to journal › Article

25 Scopus citations

F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers

Hernandez, O. M., Szczesna-Cordary, D., Knollmann, B. C., Miller, T., Bell, M., Zhao, J., Sirenko, S. G., Diaz, Z., Guzman, G., Xu, Y., Wang, Y., Kerrick, W. G. L. & Potter, J. D., Nov 4 2005, In : Journal of Biological Chemistry. 280, 44, p. 37183-37194 12 p.

Research output: Contribution to journal › Article

51 Scopus citations

2004

Inorganic phosphate affects the pCa-force relationship more than the pCa-ATPase by increasing the rate of dissociation of force generating cross-bridges in skinned fibers from both EDL and soleus muscles of the rat

Kerrick, W. G. L. & Xu, Y., Aug 24 2004, In : Journal of Muscle Research and Cell Motility. 25, 2, p. 107-117 11 p.

Research output: Contribution to journal › Article

10 Scopus citations

2003

Different Functional Properties of Troponin T Mutants that Cause Dilated Cardiomyopathy

Venkatraman, G., Harada, K., Gomes, A. V., Kerrick, W. G. L. & Potter, J. D., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 41670-41676 7 p.

Research output: Contribution to journal › Article

55 Scopus citations

2002

Activation of striated muscle: Nearest-neighbor regulatory-unit and cross-bridge influence on myofilament kinetics

Robinson, J. M., Wang, Y., Kerrick, W. G. L., Kawai, R. & Cheung, H. C., Jan 1 2002, In : Journal of molecular biology. 322, 5, p. 1065-1088 24 p.

Research output: Contribution to journal › Article

29 Scopus citations

The off rate of Ca²⁺ from troponin C is regulated by force-generating cross bridges in skeletal muscle

Wang, Y. & Kerrick, W. G. L., Jan 1 2002, In : Journal of applied physiology. 92, 6, p. 2409-2418 10 p.

Research output: Contribution to journal › Article

31 Scopus citations

2001

Abnormal Contractile Function in Transgenic Mice Expressing a Familial Hypertrophic Cardiomyopathy-linked Troponin T (I79N) Mutation

Miller, T., Szczesna, D., Housmans, P. R., Zhao, J., De Freitas, F., Gomes, A. V., Culbreath, L., McCue, J., Wang, Y., Xu, Y., Kerrick, W. G. L. & Potter, J. D., Feb 9 2001, In : Journal of Biological Chemistry. 276, 6, p. 3743-3755 13 p.

Research output: Contribution to journal › Article

93 Scopus citations

2000

Ca²⁺ measurements in skinned cardiac fibers: Effects of Mg²⁺ on Ca²⁺ activation of force and fiber ATPase

Allen, K., Xu, Y. Y. & Kerrick, G. L., Jan 2000, In : Journal of applied physiology. 88, 1, p. 180-185 6 p.

Research output: Contribution to journal › Article

23 Scopus citations

1999

Troponin C regulates the rate constant for the dissociation of force-generating myosin cross-bridges in cardiac muscle

Wang, Y., Xu, Y., Guth, K. & Kerrick, W. G. L., Dec 1 1999, In : Journal of Muscle Research and Cell Motility. 20, 7, p. 645-653 9 p.

Research output: Contribution to journal › Article

21 Scopus citations

1997

Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca²⁺-dependent events in vitro and in situ

Putkey, J. A., Liu, W., Lin, X., Ahmed, S., Zhang, M., Potter, J. D. & Kerrick, W. G. L., Jan 28 1997, In : Biochemistry. 36, 4, p. 970-978 9 p.

Research output: Contribution to journal › Article

41 Scopus citations

The effect of pH on the Ca²⁺ affinity of the Ca²⁺ regulatory sites of skeletal and cardiac troponin C in skinned muscle fibres

Parsons, B., Szczesna, D., Zhao, J., Van Slooten, G., Kerrick, W. G. L., Putkey, J. A. & Potter, J. D., Oct 18 1997, In : Journal of Muscle Research and Cell Motility. 18, 5, p. 599-609 11 p.

Research output: Contribution to journal › Article

41 Scopus citations

1994

Relationship between ATPase activity, Ca²⁺, and force in α-toxin- and β-escin-treated smooth muscle

Kerrick, W. G. L. & Hoar, P. E., Jan 1 1994, In : Canadian Journal of Physiology and Pharmacology. 72, 11, p. 1361-1367 7 p.

Research output: Contribution to journal › Article

8 Scopus citations

1993

Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction

Bourguignon, L. Y. W., Lokeshwar, V. B., Chen, X. & Kerrick, W. G. L., Jan 1 1993, In : Journal of Immunology. 151, 12, p. 6634-6644 11 p.

Research output: Contribution to journal › Article

144 Scopus citations

Rapid stimulation of Ins(1,4,5)P₃ production in rat aorta by NE: Correlation with contractile state

Pijuan, V., Sukholutskaya, I., Kerrick, W. G., Lam, M., Van Breemen, C. & Litosch, I., 1993, In : American Journal of Physiology - Heart and Circulatory Physiology. 264, 1 33-1, p. H126-H132

Research output: Contribution to journal › Article

10 Scopus citations

1992

Effects of the constitutively active proteolytic fragment of protein kinase C on the contractile properties of demembranated smooth muscle fibres

Parente, J. E., Walsh, M. P., Kerrick, W. G. L. & Hoar, P. E., Feb 1 1992, In : Journal of Muscle Research and Cell Motility. 13, 1, p. 90-99 10 p.

Research output: Contribution to journal › Article

13 Scopus citations

1991

Functional characterization of the two isoforms of troponin C from the arthropod Balanus nubilus

Ashley, C. C., Lea, T. J., Hoar, P. E., Kerrick, W. G. L., Strang, P. F. & Potter, J. D., Dec 1 1991, In : Journal of Muscle Research and Cell Motility. 12, 6, p. 532-542 11 p.

Research output: Contribution to journal › Article

17 Scopus citations

The apparent rate constant for the dissociation of force generating myosin crossbridges from actin decreases during Ca²⁺ activation of skinned muscle fibres

Kerrick, W. G. L., Potter, J. D. & Hoar, P. E., Feb 1 1991, In : Journal of Muscle Research and Cell Motility. 12, 1, p. 53-60 8 p.

Research output: Contribution to journal › Article

23 Scopus citations

1990

Effects of protein kinase-M on skinned smooth muscle fibres.

Parente, J. E., Walsh, M. P., Kerrick, W. G. & Hoar, P. E., Jan 1 1990, In : Progress in clinical and biological research. 327, p. 149-157 9 p.

Research output: Contribution to journal › Article

1 Scopus citations

Relationship between ATPase activity, isometric force, and myosin light chain phosphorylation and thiophosphorylation in skinned chicken gizzard fiber bundles.

Kerrick, W. G., Kenney, R. E. & Hoar, P. E., Jan 1 1990, In : Progress in clinical and biological research. 327, p. 635-636 2 p.

Research output: Contribution to journal › Article

2 Scopus citations

The relationship between ATPase activity, isometric force, and myosin light-chain phosphorylation and thiophosphorylation in skinned smooth muscle fiber bundles from chicken gizzard

Kenney, R. E., Hoar, P. E. & Kerrick, W. G. L., Jun 12 1990, In : Journal of Biological Chemistry. 265, 15, p. 8642-8649 8 p.

Research output: Contribution to journal › Article

29 Scopus citations

1989

The role of caldesmon in the regulation of receptor capping in mouse T-lymphoma cell

Walker, G., Kerrick, W. G. L. & Bourguignon, L. Y. W., Jan 1 1989, In : Journal of Biological Chemistry. 264, 1, p. 496-500 5 p.

Research output: Contribution to journal › Article

23 Scopus citations

1988

Mn²⁺ activates skinned smooth muscle cells in the absence of myosin light chain phosphorylation

Hoar, P. E. & Kerrick, W. G. L., Aug 1 1988, In : Pflügers Archiv European Journal of Physiology. 412, 3, p. 225-230 6 p.

Research output: Contribution to journal › Article

16 Scopus citations

Skinned ventricular fibres: troponin C extraction is species-dependent and its replacement with skeletal troponin C changes Sr²⁺ activation properties

Hoar, P. E., Potter, J. D. & Kerrick, W. G. L., Apr 1 1988, In : Journal of Muscle Research and Cell Motility. 9, 2, p. 165-173 9 p.

Research output: Contribution to journal › Article

14 Scopus citations

1987

MgADP^- increases maximum tension and Ca²⁺ sensitivity in skinned rabbit soleus fibers

Hoar, P. E., Mahoney, C. W., Kerrick, W. G. L. & Montague, D., Sep 1 1987, In : Pflügers Archiv European Journal of Physiology. 410, 1-2, p. 30-36 7 p.

Research output: Contribution to journal › Article

35 Scopus citations

Non-Ca2+-activated contraction in smooth muscle.

Kerrick, W. G. & Hoar, P. E., 1987, In : Progress in clinical and biological research. 245, p. 437-448 12 p.

Research output: Contribution to journal › Article

5 Scopus citations

1986

Smooth muscle: regulation by calcium and phosphorylation.

Kerrick, W. G. & Hoar, P. E., Dec 1 1986, In : Ciba Foundation symposium. 122, p. 183-196 14 p.

Research output: Contribution to journal › Article

2 Scopus citations

1985

Evidence that the Sr²⁺ activation properties of cardiac troponin C are altered when substituted into skinned skeletal muscle fibers

Kerrick, W. G. L., Zot, H. G., Hoar, P. E. & Potter, J. D., Jan 1 1985, In : Journal of Biological Chemistry. 260, 29, p. 15687-15693 7 p.

Research output: Contribution to journal › Article

23 Scopus citations

Myosin light chain phosphatase. Effect on the activation and relaxation of gizzard smooth muscle skinned fibers

Hoar, P. E., Pato, M. D. & Kerrick, W. G. L., Dec 1 1985, In : Journal of Biological Chemistry. 260, 15, p. 8760-8764 5 p.

Research output: Contribution to journal › Article

24 Scopus citations

1984

Effects of diethyl ether and nitrous oxide on functionally skinned myocardial cells of rabbits

Su, J. Y., Kerrick, W. G. L. & Hill, S. A., Jan 1 1984, In : Anesthesia and analgesia. 63, 4, p. 451-456 6 p.

Research output: Contribution to journal › Article

1 Scopus citations

Regulation of receptor capping in mouse lymphoma T cells by Ca²⁺-activated myosin light chain kinase

Kerrick, W. G. L. & Bourguignon, L. Y. W., 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 1 I, p. 165-169 5 p.

Research output: Contribution to journal › Article

Open Access

28 Scopus citations

1983

Gizzard Ca²⁺-independent myosin light chain kinase: Evidence in favor of the phosphorylation theory

Walsh, M. P., Bridenbaugh, R., Kerrick, W. G. L. & Hartshorne, D. J., Jan 1 1983, In : Federation Proceedings. 42, 1, p. 45-50 6 p.

Research output: Contribution to journal › Article

26 Scopus citations

Receptor capping in mouse T-lymphoma cells: A Ca²⁺ and calmodulin-stimulated ATP-dependent process

Bourguignon, L. Y. W. & Kerrick, W. G. L., Feb 1 1983, In : The Journal of Membrane Biology. 75, 1, p. 65-72 8 p.

Research output: Contribution to journal › Article

7 Scopus citations

1982

Capping of T-lymphoma cells: A Ca²⁺ and calmodulin stimulated ATP dependent process

Bourguignon, L. Y. W. & Kerrick, W. G. L., Jan 1 1982, In : Journal of Cell Biology. 95, 2 II, p. no. 4026

Research output: Contribution to journal › Article

3 Scopus citations

Evidence that myosin light chain phosphorylation regulates contraction in the body wall muscles of the sea cucumber

Kerrick, W. G. L. & Bolles, L. L., Sep 1982, In : Journal of Cellular Physiology. 112, 3, p. 307-315 9 p.

Research output: Contribution to journal › Article

6 Scopus citations

Phosphorylation-dependent activated tension in skinned gizzard muscle fibers in the absence of Ca2+.

Walsh, M. P., Bridenbaugh, R., Hartshorne, D. J. & Kerrick, W. G., Jun 10 1982, In : Journal of Biological Chemistry. 257, 11, p. 5987-5990 4 p.

Research output: Contribution to journal › Article

47 Scopus citations

Regulation of the contractile apparatus in smooth muscle.

Harshorne, D. J., Walsh, M. P., Bridenbaugh, R. & Kerrick, W. G., Jan 1 1982, In : Proceedings of the Western Pharmacology Society. 25, p. 339-341 3 p.

Research output: Contribution to journal › Article

Superprecipitation of gizzard actomyosin, and tension in gizzard muscle skinned fibers in the presence of nucleotides other than ATP

Cassidy, P. & Kerrick, W. G. L., Jul 12 1982, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 705, 1, p. 63-69 7 p.

Research output: Contribution to journal › Article

19 Scopus citations

1981

Calcium-regulatory mechanisms: Functional classification using skinned fibers

Kerrick, W. G. L., Hoar, P. E., Cassidy, P. S., Bolles, L. & Malencik, D. A., Feb 1 1981, In : Journal of General Physiology. 77, 2, p. 177-190 14 p.

Research output: Contribution to journal › Article

Open Access

28 Scopus citations

Exogenous calmodulin increases Ca²⁺ sensitivity of isometric tension activation and myosin phosphorylation in skinned smooth muscle

Cassidy, P. S., Kerrick, W. G. L., Hoar, P. E. & Malencik, D. A., Dec 1 1981, In : Pflügers Archiv European Journal of Physiology. 392, 2, p. 115-120 6 p.

Research output: Contribution to journal › Article

23 Scopus citations

Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase

Kerrick, W. G. L. & Hoar, P. E., Dec 1 1981, In : Nature. 292, 5820, p. 253-255 3 p.

Research output: Contribution to journal › Article

74 Scopus citations

Limulus and Parastichopus skinned fibers: Is regulation of contraction via a Ca²⁺ sensitive light chain kinase/phosphatase system?

Kerrick, W. G. L. & Bolles, L. L., Jan 1 1981, In : Biophysical journal. 33, 2 II, p. M-PM-F12

Research output: Contribution to journal › Article