Thomas Malek

Professor

  • 9805 Citations
1974 …2022
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  • 11 Similar Profiles
Interleukin-2 Medicine & Life Sciences
Interleukin-2 Receptors Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Regulatory T-Lymphocytes Medicine & Life Sciences
B-Lymphocytes Medicine & Life Sciences
Interleukin-7 Medicine & Life Sciences
Interleukin-15 Medicine & Life Sciences
Monoclonal Antibodies Medicine & Life Sciences

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Projects 1987 2022

Regulatory T-Lymphocytes
Interleukin-2
Autoimmune Diseases
Eragrostis
Autoimmunity
Interleukin-2
Immunity
Neoplasms
Cancer Vaccines
T-Lymphocytes
Type 1 Diabetes Mellitus
Interleukin-2
Inbred NOD Mouse
Autoimmune Diseases
Homeostasis

Induction of Tumor Immunity by Secreted HSP-gp96

Podack, E. R., Rosenblatt, J. D., Malek, T., Adkins, R., Cray, C. & Deyev, V.

National Institutes of Health

12/1/063/31/13

Project: Research project

Immunity
Neoplasms
B-Lymphocytes
Heat-Shock Proteins
Chemokines
Regulatory T-Lymphocytes
Autoimmunity
Self Tolerance
Autoimmune Diseases
Hematopoietic Stem Cell Transplantation

Research Output 1974 2019

  • 9805 Citations
  • 163 Article
  • 2 Review article

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

Toomer, K. H., Lui, J. B., Altman, N. H., Ban, Y., Chen, X. & Malek, T., Dec 1 2019, In : Nature communications. 10, 1, 1037.

Research output: Contribution to journalArticle

homeostasis
T-cells
Regulatory T-Lymphocytes
Interleukin-2
Homeostasis
6 Citations (Scopus)

Cytokine signaling in the development and homeostasis of regulatory T cells

Toomer, K. H. & Malek, T., Mar 1 2018, In : Cold Spring Harbor perspectives in biology. 10, 3, a028597.

Research output: Contribution to journalReview article

T-cells
Regulatory T-Lymphocytes
Homeostasis
Cytokines
Interleukin-2
4 Citations (Scopus)

IL-2/CD25: A long-acting fusion protein that promotes immune tolerance by selectively targeting the IL-2 receptor on regulatory t cells

Ward, N. C., Yu, A., Moro, A., Ban, Y., Chen, X., Hsiung, S., Keegan, J., Arbanas, J. M., Loubeau, M., Thankappan, A., Yamniuk, A. P., Davis, J. H., Struthers, M. & Malek, T., Nov 1 2018, In : Journal of Immunology. 201, 9, p. 2579-2592 14 p.

Research output: Contribution to journalArticle

Immune Tolerance
Interleukin-2 Receptors
Interleukin-2
Proteins
Autoimmunity
10 Citations (Scopus)

Regulatory T cells in the treatment of disease

Sharabi, A., Tsokos, M. G., Ding, Y., Malek, T., Klatzmann, D. & Tsokos, G. C., Oct 30 2018, In : Nature Reviews Drug Discovery. 17, 11, p. 823-844 22 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
Therapeutics
Neoplasms
Immunosuppressive Agents
Autoimmunity
5 Citations (Scopus)

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice

Dwyer, C. J., Bayer, A. L., Fotino, C., Yu, L., Cabello-Kindelan, C., Ward, N. C., Toomer, K. H., Chen, Z. & Malek, T., Dec 19 2017, In : Science Signaling. 10, 510, eaam9563.

Research output: Contribution to journalArticle

Inbred NOD Mouse
T-cells
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Medical problems