Thomas Malek

Professor

Microbiology & Immunology

Phone305-243-5627
Emailtmalek@umail.miami.edu

Source: Scopus

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3 Active
8 Finished

IL-2R-dependent mechanisms in regulation of Treg homeostasis and autoimmunity
Malek, T.
National Institutes of Health
12/10/19 → 11/30/24
Project: Research project
Low dose IL-2 and human regulatory T cells
Malek, T.
National Institutes of Health
11/21/17 → 11/30/22
Project: Research project
Low-dose IL-2 in Established T1D
Malek, T., Skyler, J. S. & Pugliese, A.
National Institutes of Health
8/15/17 → 7/31/23
Project: Research project
A novel IL-2 biologic and tumor immunity
Malek, T.
National Institutes of Health
12/1/15 → 11/30/18
Project: Research project
IL-2-dependent mechanisms in T1D
Malek, T.
National Institutes of Health
9/27/12 → 8/31/17
Project: Research project

10790 Citations
146 Article
13 Review article
2 Comment/debate
1 Letter
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- 1 Short survey

Sustained IL-2R signaling of limited duration by high-dose mIL-2/mCD25 fusion protein amplifies tumor-reactive CD8⁺ T cells to enhance antitumor immunity
Hernandez, R., Toomer, K. H., Põder, J., Santos Savio, A., Hsiung, S. & Malek, T. R., Apr 2021, In: Cancer Immunology, Immunotherapy. 70, 4, p. 909-921 13 p.
Research output: Contribution to journal › Article › peer-review
Medical Treatment Can Unintentionally Alter the Regulatory T-Cell Compartment in Patients with Widespread Pathophysiologic Conditions
Copsel, S. N., Malek, T. R. & Levy, R. B., Oct 2020, In: American Journal of Pathology. 190, 10, p. 2000-2012 13 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
2 Scopus citations
Persistent il-2 receptor signaling by il-2/cd25 fusion protein controls diabetes in nod mice by multiple mechanisms
Ward, N. C., Lui, J. B., Hernandez, R., Yu, L., Struthers, M., Xie, J., Savio, A. S., Dwyer, C. J., Hsiung, S., Yu, A. & Malek, T. R., Nov 2020, In: Diabetes. 69, 11, p. 2400-2413 14 p.
Research output: Contribution to journal › Article › peer-review
CD25 and protein phosphatase 2A cooperate to enhance IL-2R signaling in human regulatory T cells
Ding, Y., Yu, A., Tsokos, G. C. & Malek, T. R., 2019, In: Journal of Immunology. 203, 1, p. 93-104 12 p.
Research output: Contribution to journal › Article › peer-review
3 Scopus citations
Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
Toomer, K. H., Lui, J. B., Altman, N. H., Ban, Y., Chen, X. & Malek, T. R., Dec 1 2019, In: Nature communications. 10, 1, 1037.
Research output: Contribution to journal › Article › peer-review
12 Scopus citations