Thomas Malek

Professor

  • 9578 Citations
1974 …2022
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  • 9 Similar Profiles
Interleukin-2 Medicine & Life Sciences
Interleukin-2 Receptors Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Regulatory T-Lymphocytes Medicine & Life Sciences
B-Lymphocytes Medicine & Life Sciences
Interleukin-7 Medicine & Life Sciences
Interleukin-15 Medicine & Life Sciences
Monoclonal Antibodies Medicine & Life Sciences

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Projects 1987 2022

Low dose IL-2 and human regulatory T cells

Malek, T.

National Institutes of Health

11/21/1711/30/22

Project: Research projectResearch Project

Regulatory T-Lymphocytes
Interleukin-2
Autoimmune Diseases
Eragrostis
Autoimmunity

A novel IL-2 biologic and tumor immunity

Malek, T.

National Institutes of Health

12/1/1511/30/18

Project: Research projectExploratory/Developmental Grants

Interleukin-2
Immunity
Neoplasms
Cancer Vaccines
T-Lymphocytes

IL-2-dependent mechanisms in T1D

Malek, T.

National Institutes of Health

9/27/128/31/17

Project: Research projectResearch Project

Type 1 Diabetes Mellitus
Interleukin-2
Inbred NOD Mouse
Autoimmune Diseases
Homeostasis

Induction of Tumor Immunity by Secreted HSP-gp96

Podack, E. R., Rosenblatt, J. D., Malek, T., Adkins, R., Cray, C. & Deyev, V.

National Institutes of Health

12/1/063/31/13

Project: Research projectResearch Program Projects

Immunity
Neoplasms
B-Lymphocytes
Heat-Shock Proteins
Chemokines

Immunobiology of CD4+CD25+ T regulatory cells

Malek, T.

National Institutes of Health

5/1/0411/30/16

Project: Research projectResearch Project

Regulatory T-Lymphocytes
Autoimmunity
Self Tolerance
Autoimmune Diseases
Hematopoietic Stem Cell Transplantation

Research Output 1974 2018

  • 9578 Citations
  • 161 Article
  • 2 Review article
5 Citations

Cytokine signaling in the development and homeostasis of regulatory T cells

Toomer, K. H. & Malek, T., Mar 1 2018, In : Cold Spring Harbor perspectives in biology. 10, 3, a028597.

Research output: Contribution to journalReview article

T-cells
Regulatory T-Lymphocytes
Homeostasis
Cytokines
Interleukin-2

IL-2/CD25: A long-acting fusion protein that promotes immune tolerance by selectively targeting the IL-2 receptor on regulatory t cells

Ward, N. C., Yu, A., Moro, A., Ban, Y., Chen, X., Hsiung, S., Keegan, J., Arbanas, J. M., Loubeau, M., Thankappan, A., Yamniuk, A. P., Davis, J. H., Struthers, M. & Malek, T., Nov 1 2018, In : Journal of Immunology. 201, 9, p. 2579-2592 14 p.

Research output: Contribution to journalArticle

Immune Tolerance
Interleukin-2 Receptors
Interleukin-2
Proteins
Autoimmunity

Regulatory T cells in the treatment of disease

Sharabi, A., Tsokos, M. G., Ding, Y., Malek, T., Klatzmann, D. & Tsokos, G. C., Oct 30 2018, In : Nature Reviews Drug Discovery. 17, 11, p. 823-844 22 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
Therapeutics
Neoplasms
Immunosuppressive Agents
Autoimmunity
4 Citations

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice

Dwyer, C. J., Bayer, A. L., Fotino, C., Yu, L., Cabello-Kindelan, C., Ward, N. C., Toomer, K. H., Chen, Z. & Malek, T., Dec 19 2017, In : Science Signaling. 10, 510, eaam9563.

Research output: Contribution to journalArticle

Inbred NOD Mouse
T-cells
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Medical problems
2 Citations

The lower limit of regulatory CD4+ Foxp3++ TCRβ repertoire diversity required to control autoimmunity

Yu, A., Dee, M. J., Adeegbe, D., Dwyer, C. J., Altman, N. H. & Malek, T., Apr 15 2017, In : Journal of Immunology. 198, 8, p. 3127-3135 9 p.

Research output: Contribution to journalArticle

Autoimmunity
T-Lymphocytes
Self Tolerance
Autoantigens
Regulatory T-Lymphocytes