Projects per year
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Dive into the research topics where Thomas Malek is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Projects
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IL-2R-dependent mechanisms in regulation of Treg homeostasis and autoimmunity
12/10/19 → 11/30/24
Project: Research project
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Low-dose IL-2 in Established T1D
Malek, T., Skyler, J. S. & Pugliese, A.
8/15/17 → 7/31/23
Project: Research project
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Research Output
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Medical Treatment Can Unintentionally Alter the Regulatory T-Cell Compartment in Patients with Widespread Pathophysiologic Conditions
Copsel, S. N., Malek, T. R. & Levy, R. B., Oct 2020, In : American Journal of Pathology. 190, 10, p. 2000-2012 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Persistent il-2 receptor signaling by il-2/cd25 fusion protein controls diabetes in nod mice by multiple mechanisms
Ward, N. C., Lui, J. B., Hernandez, R., Yu, L., Struthers, M., Xie, J., Savio, A. S., Dwyer, C. J., Hsiung, S., Yu, A. & Malek, T. R., Nov 2020, In : Diabetes. 69, 11, p. 2400-2413 14 p.Research output: Contribution to journal › Article › peer-review
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Sustained IL-2R signaling of limited duration by high-dose mIL-2/mCD25 fusion protein amplifies tumor-reactive CD8+ T cells to enhance antitumor immunity
Hernandez, R., Toomer, K. H., Põder, J., Santos Savio, A., Hsiung, S. & Malek, T. R., 2020, (Accepted/In press) In : Cancer Immunology, Immunotherapy.Research output: Contribution to journal › Article › peer-review
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CD25 and protein phosphatase 2A cooperate to enhance IL-2R signaling in human regulatory T cells
Ding, Y., Yu, A., Tsokos, G. C. & Malek, T. R., 2019, In : Journal of Immunology. 203, 1, p. 93-104 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
Toomer, K. H., Lui, J. B., Altman, N. H., Ban, Y., Chen, X. & Malek, T. R., Dec 1 2019, In : Nature communications. 10, 1, 1037.Research output: Contribution to journal › Article › peer-review
7 Scopus citations