Thomas Malek

Professor

  • 10028 Citations
1974 …2023
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  • 7 Similar Profiles
Interleukin-2 Medicine & Life Sciences
Interleukin-2 Receptors Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Regulatory T-Lymphocytes Medicine & Life Sciences
B-Lymphocytes Medicine & Life Sciences
Interleukin-7 Medicine & Life Sciences
Interleukin-15 Medicine & Life Sciences
Monoclonal Antibodies Medicine & Life Sciences

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Projects 1987 2023

Regulatory T-Lymphocytes
Interleukin-2
Autoimmune Diseases
Eragrostis
Autoimmunity
Type 1 Diabetes Mellitus
Interleukin-2
Insulin
Regulatory T-Lymphocytes
Safety
Interleukin-2
Immunity
Neoplasms
Cancer Vaccines
T-Lymphocytes
Type 1 Diabetes Mellitus
Interleukin-2
Inbred NOD Mouse
Autoimmune Diseases
Homeostasis

Induction of Tumor Immunity by Secreted HSP-gp96

Podack, E. R., Rosenblatt, J. D., Malek, T., Adkins, R., Cray, C. & Deyev, V.

National Institutes of Health

12/1/063/31/13

Project: Research project

Immunity
Neoplasms
B-Lymphocytes
Heat-Shock Proteins
Chemokines

Research Output 1974 2019

  • 10028 Citations
  • 164 Article
  • 2 Review article

CD25 and protein phosphatase 2A cooperate to enhance IL-2R signaling in human regulatory T cells

Ding, Y., Yu, A., Tsokos, G. C. & Malek, T., Jan 1 2019, In : Journal of Immunology. 203, 1, p. 93-104 12 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Regulatory T-Lymphocytes
Interleukin-2
Catalytic Domain
Phosphorylation
1 Citation (Scopus)

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

Toomer, K. H., Lui, J. B., Altman, N. H., Ban, Y., Chen, X. & Malek, T., Dec 1 2019, In : Nature communications. 10, 1, 1037.

Research output: Contribution to journalArticle

homeostasis
T-cells
Regulatory T-Lymphocytes
Interleukin-2
Homeostasis
8 Citations (Scopus)

Cytokine signaling in the development and homeostasis of regulatory T cells

Toomer, K. H. & Malek, T., Mar 1 2018, In : Cold Spring Harbor perspectives in biology. 10, 3, a028597.

Research output: Contribution to journalReview article

T-cells
Regulatory T-Lymphocytes
Homeostasis
Cytokines
Interleukin-2
6 Citations (Scopus)

IL-2/CD25: A long-acting fusion protein that promotes immune tolerance by selectively targeting the IL-2 receptor on regulatory t cells

Ward, N. C., Yu, A., Moro, A., Ban, Y., Chen, X., Hsiung, S., Keegan, J., Arbanas, J. M., Loubeau, M., Thankappan, A., Yamniuk, A. P., Davis, J. H., Struthers, M. & Malek, T., Nov 1 2018, In : Journal of Immunology. 201, 9, p. 2579-2592 14 p.

Research output: Contribution to journalArticle

Immune Tolerance
Interleukin-2 Receptors
Interleukin-2
Proteins
Autoimmunity
23 Citations (Scopus)

Regulatory T cells in the treatment of disease

Sharabi, A., Tsokos, M. G., Ding, Y., Malek, T., Klatzmann, D. & Tsokos, G. C., Oct 30 2018, In : Nature Reviews Drug Discovery. 17, 11, p. 823-844 22 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
Therapeutics
Neoplasms
Immunosuppressive Agents
Autoimmunity