Tatjana Abaffy, Ph.D.

Research Assistant Professor

  • 433 Citations
19942018
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Personal profile

Research interests

My research interest is focused on olfactory recognition. I am studying molecular mechanisms of activation of olfactory receptors (GPCRs) and receptor/odorant interactions by combining high throughput electrophysiology, mutagenesis, computational homology modeling and in silico analysis (docking and virtual screening). I am also interested in cancer detection based on volatile metabolomics. Volatile compounds released from cancerous tissue (as a result of altered metabolism) form a unique odorant signature that can be detected by olfactory system. The first step in exploring this hypothesis is identification of volatile tumor markers. We are using gas chromatography combined with mass spectrometry to isolate and identify candidate markers. We are also examining differences between normal skin and melanoma tissue profiles to seek potential markers.

Training Experience

2011TRAINING IN NEW CONCEPTS OF TOF-MS FOR FAST GC AND GCXGC APPLICATIONS at 2011 Pittsburgh Conference & Exposition on Analytical Chemistry and Applied spectroscopy, PITTCON 2011
2010TRAINING IN SOLID-PHASE MICROEXTRACTION at 2010 Pittsburgh Conference & Exposition on Analytical Chemistry and Applied spectroscopy
2007 - 2007TRAINING IN MOLECULAR MODELING at Molsoft LLC, La Jolla, CA. Protein structure and drug discovery

Education/Academic qualification

University of Miami

2007 → …

University of Miami

20062007

University of Miami

20032006

University of Miami

20002003

External positions

Research Assistant Professor, Molecular and Cellular Pharmacology, University of Miami

2007 → …

Associate Scientist, Molecular and Cellular Pharmacology, University of Miami

20062007

Assistant Scientist, Molecular and Cellular Pharmacology, University of Miami

20032006

Postdoctoral Fellow, Physiology and Biophysics, University of Miami

20002003

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  • 1 Similar Profiles
Odorant Receptors Medicine & Life Sciences
Metabolomics Medicine & Life Sciences
Melanoma Medicine & Life Sciences
Skin Medicine & Life Sciences
lauric acid Medicine & Life Sciences
Ligands Chemical Compounds
Computer Simulation Medicine & Life Sciences
Rats Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2008 2011

Detection of Melanoma by Canine Olfactory Receptors.

Abaffy, T.

National Institutes of Health

9/29/088/31/11

Project: Research projectExploratory/Developmental Grants

Odorant Receptors
Canidae
Melanoma
Aptitude
Biomarkers

Research Output 1994 2018

  • 433 Citations
  • 14 Article

A testosterone metabolite 19-hydroxyandrostenedione induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olfactory receptor

Abaffy, T., Bain, J. R., Muehlbauer, M. J., Spasojevic, I., Lodha, S., Bruguera, E., O'Neal, S. K., Kim, S. Y. & Matsunami, H., May 28 2018, In : Frontiers in Oncology. 8, MAY, 162.

Research output: Contribution to journalArticle

Odorant Receptors
Testosterone
Prostatic Neoplasms
Aromatase
Phosphopyruvate Hydratase
14 Citations

Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation

Bavan, S., Sherman, B., Luetje, C. W. & Abaffy, T., Mar 17 2014, In : PLoS One. 9, 3, e92064.

Research output: Contribution to journalArticle

Odorant Receptors
olfactory receptors
Computer Simulation
Screening
Ligands
27 Citations

A non-invasive method for in vivo skin volatile compounds sampling

Jiang, R., Cudjoe, E., Bojko, B., Abaffy, T. & Pawliszyn, J., Dec 4 2013, In : Analytica Chimica Acta. 804, p. 111-119 9 p.

Research output: Contribution to journalArticle

skin
Skin
Sampling
sampling
Membranes
37 Citations

Comparative analysis of volatile metabolomics signals from melanoma and benign skin: A pilot study

Abaffy, T., Moller, M., Riemer, D. D., Milikowski, C. & DeFazio, R. A., Oct 1 2013, In : Metabolomics. 9, 5, p. 998-1008 11 p.

Research output: Contribution to journalArticle

lauric acid
Volatile Organic Compounds
Metabolomics
Melanoma
Skin
13 Citations

A case report-volatile metabolomic signature of malignant melanoma using matching skin as a control

Abaffy, T., Moller, M., Riemer, D. D., Milikowski, C. & Defazio, R. A., Dec 1 2011, In : Journal of Cancer Science and Therapy. 3, 6, p. 140-144 5 p.

Research output: Contribution to journalArticle

Metabolomics
Melanoma
Skin
Biomarkers
Skin Neoplasms

Activities 2010 2011

  • 5 Types of External academic engagement - Membership of external research organization
  • 1 Editorial activity

Reviews for Scientific Awards Committee (SAC) University of Miami

Tatjana Abaffy (Other)
Jul 2011

Activity: Other activity typesTypes of External academic engagement - Membership of external research organization

Journal of Pharmacogenomics and Pharmacoproteomics (Journal)

Tatjana Abaffy (Editorial board member)
Jan 2011

Activity: Editorial work typesEditorial activity

Reviews for Italian Ministry of Health Department of Innovation, General Directorate for Health and Technologies Research

Tatjana Abaffy (Other)
Aug 2010Jan 2011

Activity: Other activity typesTypes of External academic engagement - Membership of external research organization

Reviews for NeuroSignals Journal

Tatjana Abaffy (Other)
1800

Activity: Other activity typesTypes of External academic engagement - Membership of external research organization

Reviews for World Journal of Biological Chemistry (WJBC)

Tatjana Abaffy (Other)
1800

Activity: Other activity typesTypes of External academic engagement - Membership of external research organization