Stephen D Nimer, M.D.

Professor

  • 18712 Citations
1975 …2022
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Research Output 1975 2019

2019
1 Citation (Scopus)

ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis

Guo, Y., Zhou, Y., Yamatomo, S., Yang, H., Zhang, P., Chen, S., Nimer, S. D., Zhao, Z. J., Xu, M., Bai, J. & Yang, F-C., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Primary Myelofibrosis

Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation

Zhang, M. M., Liu, N., Zhang, Y. L., Rong, B., Wang, X. L., Xu, C. H., Xie, Y. Y., Shen, S., Zhu, J., Nimer, S. D., Chen, Z., Chen, S. J., Roeder, R. G., Lan, F., Wang, L., Huang, Q. H. & Sun, X. J., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalLetter

Cell Differentiation
1 Citation (Scopus)

Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis

Liu, N., Song, J., Xie, Y., Wang, X. L., Rong, B., Man, N., Zhang, M. M., Zhang, Q., Gao, F. F., Du, M. R., Zhang, Y., Shen, J., Xu, C. H., Hu, C. L., Wu, J. C., Liu, P., Zhang, Y. L., Xie, Y. Y., Liu, P., Huang, J. Y. & 9 others, Huang, Q. H., Lan, F., Shen, S., Nimer, S. D., Chen, Z., Chen, S. J., Roeder, R. G., Wang, L. & Sun, X. J., Jan 15 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 3, p. 890-899 10 p.

Research output: Contribution to journalArticle

Leukemia
Transcription Factors
Proteins
Acute Myeloid Leukemia
Genes

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216), (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., Jermakowicz, A. M., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D. G., Watts, J., Vega, F. & Nimer, S. D., Jan 14 2019, In : Cancer Cell. 35, 1, 1 p.

Research output: Contribution to journalComment/debate

Hematopoiesis
Names
Neoplasms
coactivator-associated arginine methyltransferase 1

Risk of disease progression in low-risk MDS is linked to distinct epigenetic subtypes

Qin, T., Sotzen, J., Rampal, R. K., Rapaport, F. T., Levine, R. L., Klimek, V., Nimer, S. D. & Figueroa, M., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalLetter

Epigenomics
Disease Progression
2018
5 Citations (Scopus)

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

Hematopoiesis
Acute Myeloid Leukemia
Cell Cycle
Protein-Arginine N-Methyltransferases
Apoptosis
1 Citation (Scopus)

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy

Zhang, P., He, F., Bai, J., Yamamoto, S., Chen, S., Zhang, L., Sheng, M., Zhang, L., Guo, Y., Man, N., Yang, H., Wang, S., Cheng, T., Nimer, S. D., Zhou, Y., Xu, M., Wang, Q. F. & Yang, F-C., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5383-5398 16 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Chromatin
Mutation
Hematopoietic Stem Cells
Genes
4 Citations (Scopus)

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

Luo, H., Wang, F., Zha, J., Li, H., Yan, B., Du, Q., Yang, F-C., Sobh, A., Vulpe, C., Drusbosky, L., Cogle, C., Chepelev, I., Xu, B., Nimer, S. D., Licht, J., Qiu, Y., Chen, B., Xu, M. & Huang, S., Aug 23 2018, In : Blood. 132, 8, p. 837-848 12 p.

Research output: Contribution to journalArticle

Transcription
Acute Myeloid Leukemia
Gene expression
Chromatin
Genes

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216) (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Nov 12 2018, In : Cancer Cell. 34, 5, 1 p.

Research output: Contribution to journalComment/debate

Hematopoiesis
Names
Neoplasms
coactivator-associated arginine methyltransferase 1
23 Citations (Scopus)

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Yang, H., Kurtenbach, S., Guo, Y., Lohse, I., Durante, M. A., Li, J., Li, Z., Al-Ali, H., Li, L., Chen, Z., Field, M. G., Zhang, P., Chen, S., Yamamoto, S., Li, Z., Zhou, Y., Nimer, S. D., William Harbour, J., Wahlestedt, C. R., Xu, M. & 1 others, Yang, F-C., Jan 18 2018, In : Blood. 131, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

Comb and Wattles
Stem cells
Chromatin
Mass spectrometry
Neoplasms
26 Citations (Scopus)

Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML

Kaushik, S., Liu, F., Veazey, K. J., Gao, G., Das, P., Neves, L. F., Lin, K., Zhong, Y., Lu, Y., Giuliani, V., Bedford, M. T., Nimer, S. D. & Santos, M. A., Feb 1 2018, In : Leukemia. 32, 2, p. 499-509 11 p.

Research output: Contribution to journalArticle

Leukemia
Myeloid-Lymphoid Leukemia Protein
Protein-Arginine N-Methyltransferases
Cyclin-Dependent Kinase Inhibitor p21
human PRMT2 protein

p300 suppresses leukemia development in NUP98-HOXD13 driven myelodysplastic syndrome

Man, N. & Nimer, S. D., Jun 1 2018, In : Oncotarget. 9, 42, p. 26603-26604 2 p.

Research output: Contribution to journalEditorial

Myelodysplastic Syndromes
Leukemia
nuclear pore complex protein 98
4 Citations (Scopus)

Pathobiological pseudohypoxia as a putative mechanism underlying myelodysplastic syndromes

Hayashi, Y., Zhang, Y., Yokota, A., Yan, X., Liu, J., Choi, K., Li, B., Sashida, G., Peng, Y., Xu, Z., Huang, R., Zhang, L., Freudiger, G. M., Wang, J., Dong, Y., Zhou, Y., Wang, J., Wu, L., Bu, J., Chen, A. & 21 others, Zhao, X., Sun, X., Chetal, K., Olsson, A., Watanabe, M., Romick-Rosendale, L. E., Harada, H., Shih, L. Y., Tse, W., Bridges, J. P., Caligiuri, M. A., Huang, T., Zheng, Y., Witte, D. P., Wang, Q. F., Qu, C. K., Salomonis, N., Grimes, H. L., Nimer, S. D., Xiao, Z. & Huang, G., Nov 1 2018, In : Cancer Discovery. 8, 11, p. 1438-1457 20 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Phenotype
Mutation
Hypoxia-Inducible Factor 1
Epigenomics
6 Citations (Scopus)

PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival

Lu, X., Fernando, T. M., Lossos, C., Yusufova, N., Liu, F., Fontán, L., Durant, M., Geng, H., Melnick, J., Luo, Y., Vega, F., Moy, V. T., Inghirami, G., Nimer, S. D., Melnick, A. M. & Lossos, I., Nov 8 2018, In : Blood. 132, 19, p. 2026-2039 14 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Germinal Center
Oncogene Proteins
Lymphoma
Cell Survival
11 Citations (Scopus)

PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes

Hamard, P. J., Santiago, G. E., Liu, F., Karl, D. L., Martinez, C., Man, N., Mookhtiar, A. K., Duffort, S., Greenblatt, S., Verdun, R. E. & Nimer, S. D., Sep 4 2018, In : Cell Reports. 24, 10, p. 2643-2657 15 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Alternative Splicing
DNA Repair
Histones
Repair
5 Citations (Scopus)

Recent advances in the understanding and treatment of acute myeloid leukemia

Watts, J. & Nimer, S. D., Jan 1 2018, In : F1000Research. 7, 1196.

Research output: Contribution to journalReview article

Acute Myeloid Leukemia
Pharmaceutical Preparations
Drug Approval
Molecular biology
Genomics
4 Citations (Scopus)

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Guo, Y., Yang, H., Chen, S., Zhang, P., Li, R., Nimer, S. D., William Harbour, J., Xu, M. & Yang, F-C., Apr 2 2018, (Accepted/In press) In : Leukemia. p. 1-4 4 p.

Research output: Contribution to journalArticle

Neoplasms
1 Citation (Scopus)

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)

Chu, Y., Zhao, Z., Sant, D. W., Zhu, G., Greenblatt, S. M., Liu, L., Wang, J., Cao, Z., Tho, J. C., Chen, S., Liu, X., Zhang, P., Maciejewski, J. P., Nimer, S. D., Wang, G., Yuan, W., Yang, F-C. & Xu, M., Jan 1 2018, (Accepted/In press) In : Genomics, Proteomics and Bioinformatics.

Research output: Contribution to journalArticle

Osteoclasts
Genomics
Macrophage
Macrophages
Translocation
2017
12 Citations (Scopus)

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

Li, Z., Zhang, P., Yan, A., Guo, Z., Ban, Y., Li, J., Chen, S., Yang, H., He, Y., Li, J., Guo, Y., Zhang, W., Hajiramezanali, E., An, H., Fajardo, D., William Harbour, J., Ruan, Y., Nimer, S. D., Yu, P., Chen, X. & 2 others, Xu, M. & Yang, F-C., Jan 1 2017, In : Science advances. 3, 1, e1601602.

Research output: Contribution to journalArticle

Chromatids
Hematopoiesis
Gene Expression
Telophase
Chromatin Immunoprecipitation
8 Citations (Scopus)

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner

Man, N., Tan, Y., Sun, X. J., Liu, F., Cheng, G., Greenblatt, S. M., Martinez, C., Karl, D. L., Ando, K., Sun, M., Hou, D., Chen, B., Xu, M., Yang, F-C., Chen, Z., Chen, S., Nimer, S. D. & Wang, L., May 18 2017, In : Blood. 129, 20, p. 2782-2792 11 p.

Research output: Contribution to journalArticle

Autophagy
Caspase 3
Modulation
Acute Myeloid Leukemia
Leukemia
4 Citations (Scopus)

Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q)

Fenaux, P., Giagounidis, A., Selleslag, D., Beyne-Rauzy, O., Mittelman, M., Muus, P., Nimer, S. D., Hellström-Lindberg, E., Powell, B. L., Guerci-Bresler, A., Sekeres, M. A., Deeg, H. J., Del Cañizo, C., Greenberg, P. L., Shammo, J. M., Skikne, B., Yu, X. & List, A. F., Jun 26 2017, In : Journal of Hematology and Oncology. 10, 1, 131.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Acute Myeloid Leukemia
Age Groups
Erythrocyte Transfusion
Cytogenetics
2 Citations (Scopus)

Covalent modifications of RUNX proteins: Structure affects function

Blumenthal, E., Greenblatt, S., Huang, G., Ando, K., Xu, Y. & Nimer, S. D., 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 962. p. 33-44 12 p. (Advances in Experimental Medicine and Biology; vol. 962).

Research output: Chapter in Book/Report/Conference proceedingChapter

Post Translational Protein Processing
Proteins
Protein Stability
Hematologic Neoplasms
Gene expression
3 Citations (Scopus)

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation

Huber, F. M., Greenblatt, S. M., Davenport, A. M., Martinez, C., Xu, Y., Vu, L. P., Nimer, S. D. & Hoelz, A., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. 6016-6021 6 p.

Research output: Contribution to journalArticle

Histones
Plant Structures
Acute Myeloid Leukemia
Mutagenesis
Chromatin
6 Citations (Scopus)

Loss of Asxl2 leads to myeloid malignancies in mice

Li, J., He, F., Zhang, P., Chen, S., Shi, H., Sun, Y., Guo, Y., Yang, H., Man, N., Greenblatt, S., Li, Z., Guo, Z., Zhou, Y., Wang, L., Morey, LL., Williams, S. L., Chen, X., Wang, Q. T., Nimer, S. D., Yu, P. & 3 others, Wang, Q. F., Xu, M. & Yang, F-C., Jun 8 2017, In : Nature Communications. 8, 15456.

Research output: Contribution to journalArticle

stem cells
Hematopoietic Stem Cells
Stem cells
mice
deletion
11 Citations (Scopus)

Loss of p300 accelerates MDS-associated leukemogenesis

Cheng, G., Liu, F., Asai, T., Lai, F., Man, N., Xu, H., Chen, S., Greenblatt, S., Hamard, P. J., Ando, K., Chen, X., Wang, L., Martinez, C., Tadi, M., Wang, L., Xu, M., Yang, F-C., Shiekhattar, R. & Nimer, S. D., Jan 6 2017, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

CREB-Binding Protein
Myelodysplastic Syndromes
Hematopoietic Stem Cells
Histone Code
Neoplasms
6 Citations (Scopus)

Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma

Thomas, A. A., Abrey, L. E., Terziev, R., Raizer, J., Martinez, N. L., Forsyth, P., Paleologos, N., Matasar, M., Sauter, C. S., Moskowitz, C., Nimer, S. D., Deangelis, L. M., Kaley, T., Grimm, S., Louis, D. N., Cairncross, J. G., Panageas, K. S., Briggs, S., Faivre, G., Mohile, N. A. & 8 others, Mehta, J., Jonsson, P., Chakravarty, D., Gao, J., Schultz, N., Brennan, C. W., Huse, J. T. & Omuro, A., Oct 1 2017, In : Neuro-Oncology. 19, 10, p. 1380-1390 11 p.

Research output: Contribution to journalArticle

temozolomide
Oligodendroglioma
Stem Cells
Transplants
Drug Therapy
2016
10 Citations (Scopus)

Arginine methyltransferases in normal and malignant hematopoiesis

Greenblatt, S. M., Liu, F. & Nimer, S. D., Jun 1 2016, In : Experimental Hematology. 44, 6, p. 435-441 7 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Hematopoiesis
Hematopoietic Stem Cells
Arginine
Histone Code
49 Citations (Scopus)

Beyond transcription factors: How oncogenic signalling reshapes the epigenetic landscape

Liu, F., Wang, L., Perna, F. & Nimer, S. D., May 25 2016, In : Nature Reviews Cancer. 16, 6, p. 359-372 14 p.

Research output: Contribution to journalReview article

Epigenomics
Chromatin
Transcription Factors
Histone Code
Inborn Genetic Diseases
6 Citations (Scopus)

Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin

Man, N., Sun, X. J., Tan, Y., García-Cao, M., Liu, F., Cheng, G., Hatlen, M., Xu, H., Shah, R., Chastain, N., Liu, N., Huang, G., Zhou, Y., Sheng, M., Song, J., Yang, F-C., Benezra, R., Nimer, S. D. & Wang, L., 2016, In : Blood. 127, 19, p. 2322-2326 5 p.

Research output: Contribution to journalArticle

Leukemia
DNA
Liver
Bone
Bone Marrow Cells
59 Citations (Scopus)

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

Guryanova, O. A., Shank, K., Spitzer, B., Luciani, L., Koche, R. P., Garrett-Bakelman, F. E., Ganzel, C., Durham, B. H., Mohanty, A., Hoermann, G., Rivera, S. A., Chramiec, A. G., Pronier, E., Bastian, L., Keller, M. D., Tovbin, D., Loizou, E., Weinstein, A. R., Gonzalez, A. R., Lieu, Y. K. & 19 others, Rowe, J. M., Pastore, F., McKenney, A. S., Krivtsov, A. V., Sperr, W. R., Cross, J. R., Mason, C. E., Tallman, M. S., Arcila, M. E., Abdel-Wahab, O., Armstrong, S. A., Kubicek, S., Staber, P. B., Gönen, M., Paietta, E. M., Melnick, A. M., Nimer, S. D., Mukherjee, S. & Levine, R. L., Dec 1 2016, In : Nature Medicine. 22, 12, p. 1488-1495 8 p.

Research output: Contribution to journalArticle

Nucleosomes
Anthracyclines
Acute Myeloid Leukemia
Chemotherapy
Mutation
3 Citations (Scopus)

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms

Asai, T., Hatlen, M. A., Lossos, C., Ndiaye-Lobry, D., Deblasio, A., Murata, K., Fleisher, M., Cortizas, E. M., Verdun, R. E., Petrini, J. & Nimer, S. D., Mar 10 2016, In : Scientific Reports. 6, 22760.

Research output: Contribution to journalArticle

Plasma Cell Neoplasms
Plasma Cells
Multiple Myeloma
Exome
Oncogenes
12 Citations (Scopus)

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles

Hatlen, M. A., Arora, K., Vacic, V., Grabowska, E. A., Liao, W., Riley-Gillis, B., Oschwald, D. M., Wang, L., Joergens, J. E., Shih, A. H., Rapaport, F., Gu, S., Voza, F., Asai, T., Neel, B. G., Kharas, M. G., Gonen, M., Levine, R. L. & Nimer, S. D., 2016, In : Journal of Experimental Medicine. 213, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Alleles
Mutation
Chromosome Aberrations
Leukemia
12 Citations (Scopus)

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

Taggart, J., Ho, T. C., Amin, E., Xu, H., Barlowe, T. S., Perez, A. R., Durham, B. H., Tivnan, P., Okabe, R., Chow, A., Vu, L., Park, S. M., Prieto, C., Famulare, C., Patel, M., Lengner, C. J., Verma, A., Roboz, G., Guzman, M., Klimek, V. M. & 4 others, Abdel-Wahab, O., Leslie, C., Nimer, S. D. & Kharas, M. G., Feb 22 2016, In : Nature Communications. 7, 10739.

Research output: Contribution to journalArticle

stem cells
Myelodysplastic Syndromes
Stem cells
Stem Cells
Hematopoietic Stem Cells
7 Citations (Scopus)

Mutational landscape and antiproliferative functions of ELF transcription factors in human cancer

Ando, M., Kawazu, M., Ueno, T., Koinuma, D., Ando, K., Koya, J., Kataoka, K., Yasuda, T., Yamaguchi, H., Fukumura, K., Yamato, A., Soda, M., Sai, E., Yamashita, Y., Asakage, T., Miyazaki, Y., Kurokawa, M., Miyazono, K., Nimer, S. D., Yamasoba, T. & 1 others, Mano, H., Apr 1 2016, In : Cancer Research. 76, 7, p. 1814-1824 11 p.

Research output: Contribution to journalArticle

Transcription Factors
Neoplasms
Apoptosis
Growth Inhibitors
Mutation
22 Citations (Scopus)

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

Shirakawa, K., Wang, L., Man, N., Maksimoska, J., Sorum, A. W., Lim, H. W., Lee, I. S., Shimazu, T., Newman, J. C., Schröder, S., Ott, M., Marmorstein, R., Meier, J., Nimer, S. D. & Verdin, E., May 31 2016, In : eLife. 5, MAY2016, e11156.

Research output: Contribution to journalArticle

Diflunisal
Salicylates
Metabolites
Lysine
Anti-Inflammatory Agents
2015
23 Citations (Scopus)

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

Zong, H., Gozman, A., Caldas-Lopes, E., Taldone, T., Sturgill, E., Brennan, S., Ochiana, SO. O., Gomes-DaGama, EM. M., Sen, S., Rodina, A., Koren, J., Becker, MW. W., Rudin, CM. M., Melnick, A., Levine, RL. L., Roboz, GJ. J., Nimer, S. D., Chiosis, G. & Guzman, ML. L., 2015, In : Cell Reports. 13, 10, p. 2159-2173 15 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Tumors
Chemical activation
Neoplasms
Phosphatidylinositol 3-Kinases
34 Citations (Scopus)

Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis

Liu, F., Cheng, G., Hamard, P. J., Greenblatt, S., Wang, L., Man, N., Perna, F., Xu, H., Tadi, M., Luciani, L. & Nimer, S. D., Sep 1 2015, In : Journal of Clinical Investigation. 125, 9, p. 3532-3544 13 p.

Research output: Contribution to journalArticle

Hematopoiesis
Hematopoietic Stem Cells
Methyltransferases
Epigenomics
Arginine
44 Citations (Scopus)

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

Zhao, Z., Chen, L., Dawlaty, M. M., Pan, F., Weeks, O., Zhou, Y., Cao, Z., Shi, H., Wang, J., Lin, L., Chen, S., Yuan, W., Qin, Z., Ni, H., Nimer, S. D., Yang, F-C., Jaenisch, R., Jin, P. & Xu, M., Nov 24 2015, In : Cell Reports. 13, 8, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Cells
Dioxygenases
Hematologic Neoplasms
Neoplasms
1 Citation (Scopus)

Erratum: Extended survival and reduced risk of AML progression in erythroid-responsive lenalidomide-treated patients with lower-risk del(5q) MDS (Leukemia (2014) 29 (1033-1040) DOI: 10.1038/leu.2013.305)

List, A. F., Bennett, J. M., Sekeres, M. A., Skikne, B., Fu, T., Shammo, J. M., Nimer, S. D., Knight, R. D. & Giagounidis, A., Dec 1 2015, In : Leukemia. 29, 12, p. 2452 1 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

Kotini, A. G., Chang, C. J., Boussaad, I., Delrow, J. J., Dolezal, E. K., Nagulapally, A. B., Perna, F., Fishbein, G. A., Klimek, V. M., Hawkins, R. D., Huangfu, D., Murry, C. E., Graubert, T., Nimer, S. D. & Papapetrou, E. P., Jun 11 2015, In : Nature Biotechnology. 33, 6, p. 646-655 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Functional analysis
Myelodysplastic Syndromes
Chromosomes
Stem cells
4 Citations (Scopus)

Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis

Mizutani, S., Yoshida, T., Zhao, X., Nimer, S. D., Taniwaki, M. & Okuda, T., Sep 1 2015, In : British Journal of Haematology. 170, 6, p. 859-873 15 p.

Research output: Contribution to journalArticle

Methylation
Arginine
Homeostasis
Hematopoiesis
T-Lymphocytes
98 Citations (Scopus)

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia

Shih, A. H., Jiang, Y., Meydan, C., Shank, K., Pandey, S., Barreyro, L., Antony-Debre, I., Viale, A., Socci, N., Sun, Y., Robertson, A., Cavatore, M., deStanchina, E., Hricik, T., Rapaport, F., Woods, B., Wei, C., Hatlen, M., Baljevic, M., Nimer, S. D. & 8 others, Tallman, M., Paietta, E., Cimmino, L., Aifantis, I., Steidl, U., Mason, C., Melnick, A. & Levine, R. L., Apr 13 2015, In : Cancer Cell. 27, 4, p. 502-515 14 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Epigenomics
Mutation
DNA Methylation
Alleles
6 Citations (Scopus)

PARP inhibitors: A treatment option for AML?

Wang, L., Hamard, P. J. & Nimer, S. D., Dec 8 2015, In : Nature Medicine. 21, 12, p. 1393-1394 2 p.

Research output: Contribution to journalArticle

Oncogenes
Acute Myeloid Leukemia
Transcription Factors
Poly(ADP-ribose) Polymerase Inhibitors
10 Citations (Scopus)

Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression

Wang, L., Man, N., Sun, X. J., Tan, Y., Cao, M. G., Liu, F., Hatlen, M., Xu, H., Huang, G., Mattlin, M., Mehta, A., Rampersaud, E., Benezra, R. & Nimer, S. D., Jul 30 2015, In : Blood. 126, 5, p. 640-650 11 p.

Research output: Contribution to journalArticle

Leukemia
DNA
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Proto-Oncogene Proteins c-akt
3 Citations (Scopus)

The polycomb group protein L3MBTL1 repreßes a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells

Perna, F., Vu, L. P., Themeli, M., Kriks, S., Hoya-Arias, R., Khanin, R., Hricik, T., Mansilla-Soto, J., Papapetrou, E. P., Levine, R. L., Studer, L., Sadelain, M. & Nimer, S. D., 2015, In : Stem Cell Reports. 4, 4, p. 658-669 12 p.

Research output: Contribution to journalArticle

Polycomb-Group Proteins
Pluripotent Stem Cells
Stem cells
Epigenomics
Nucleic Acid Regulatory Sequences
33 Citations (Scopus)

The role of histone acetyltransferases in normal and malignant hematopoiesis

Sun, X. J., Man, N., Tan, Y., Nimer, S. D. & Wang, L., 2015, In : Frontiers in Oncology. 5, MAY, 108.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Hematopoiesis
Hematologic Neoplasms
Acetylation
Epigenomics
2014
47 Citations (Scopus)

Chromatin modifiers and the promise of epigenetic therapy in acute leukemia

Greenblatt, S. M. & Nimer, S. D., Jan 1 2014, In : Leukemia. 28, 7, p. 1396-1406 11 p.

Research output: Contribution to journalArticle

Epigenomics
Chromatin
Leukemia
Mutation
Hematopoietic Stem Cells
121 Citations (Scopus)

DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

Rampal, R., Alkalin, A., Madzo, J., Vasanthakumar, A., Pronier, E., Patel, J., Li, Y., Ahn, J., Abdel-Wahab, O., Shih, A., Lu, C., Ward, P. S., Tsai, J. J., Hricik, T., Tosello, V., Tallman, J. E., Zhao, X., Daniels, D., Dai, Q., Ciminio, L. & 14 others, Aifantis, I., He, C., Fuks, F., Tallman, M. S., Ferrando, A., Nimer, S. D., Paietta, E., Thompson, C. B., Licht, J. D., Mason, C. E., Godley, L. A., Melnick, A., Figueroa, M. & Levine, R. L., Jan 1 2014, In : Cell Reports. 9, 5, p. 1841-1856 16 p.

Research output: Contribution to journalArticle

DNA Fingerprinting
Acute Myeloid Leukemia
Mutation
DNA
5-Methylcytosine
14 Citations (Scopus)

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

Zhao, X., Chen, A., Yan, X., Zhang, Y., He, F., Hayashi, Y., Dong, Y., Rao, Y., Li, B., Conway, R. M., Maiques-Diaz, A., Elf, S. E., Huang, N., Zuber, J., Xiao, Z., Tse, W., Tenen, D. G., Wang, Q., Chen, W., Mulloy, J. C. & 2 others, Nimer, S. D. & Huang, G., Mar 13 2014, In : Blood. 123, 11, p. 1729-1738 10 p.

Research output: Contribution to journalArticle

Myeloid-Lymphoid Leukemia Protein
Core Binding Factors
Hematopoietic Stem Cells
Stem cells
Leukemia
46 Citations (Scopus)

Extended survival and reduced risk of AML progression in erythroid-responsive lenalidomide-treated patients with lower-risk del(5q) MDS

List, A. F., Bennett, J. M., Sekeres, M. A., Skikne, B., Fu, T., Shammo, J. M., Nimer, S. D., Knight, R. D. & Giagounidis, A., Jan 1 2014, In : Leukemia. 28, 5, p. 1033-1040 8 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Erythrocyte Transfusion
Acute Myeloid Leukemia
Survival
Cytogenetics