Stephen D Nimer, M.D.

Professor

  • 17786 Citations
1975 …2022
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Myelodysplastic Syndromes Medicine & Life Sciences
Acute Myeloid Leukemia Medicine & Life Sciences
Leukemia Medicine & Life Sciences
Hematopoietic Stem Cells Medicine & Life Sciences
Granulocyte-Macrophage Colony-Stimulating Factor Medicine & Life Sciences
Hematopoiesis Medicine & Life Sciences
Stem Cells Medicine & Life Sciences
Transcription Factors Medicine & Life Sciences

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Projects 1978 2022

Targeting p300 and lysine acetylation in AML

Nimer, S. D.

National Institutes of Health

9/17/127/31/22

Project: Research projectResearch Project

Acute Myeloid Leukemia
Acetylation
Lysine
Proteins
Leukemia

The function of I(3)mbt in hematopoietic cancers

Nimer, S. D.

National Institutes of Health

8/1/035/31/09

Project: Research projectResearch Project

Polycomb-Group Proteins
Neoplasms
Proteins
Genes
Hematologic Neoplasms

VITAMIN D3-INDUCIBLE GENES MEDIATING DIFFERENTIATION

Nimer, S. D. & Freedman, L.

National Institutes of Health

5/27/974/30/06

Project: Research projectResearch Project

Cholecalciferol
Cell Differentiation
Myeloid Cells
Nuclear Receptor Coactivators
Genes

FUNCTION OF MEF IN HEMATOPOIETIC CELLS

Nimer, S. D.

National Institutes of Health

1/1/976/30/13

Project: Research projectResearch Project, High Priority, Short Term Project Award

Hematopoietic Stem Cells
Cell Cycle
Natural Killer Cells
Cell Aging
Innate Immunity
Colony-Stimulating Factors
Intercellular Signaling Peptides and Proteins
Myeloid Leukemia
T-Lymphocytes
Acute Myeloid Leukemia

Research Output 1975 2018

1 Citations

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 othersYang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

Hematopoiesis
Acute Myeloid Leukemia
Cell Cycle
Protein-Arginine N-Methyltransferases
Apoptosis

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy

Zhang, P., He, F., Bai, J., Yamamoto, S., Chen, S., Zhang, L., Sheng, M., Zhang, L., Guo, Y., Man, N., Yang, H., Wang, S., Cheng, T., Nimer, S. D., Zhou, Y., Xu, M., Wang, Q. F. & Yang, F-C., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5383-5398 16 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Chromatin
Mutation
Hematopoietic Stem Cells
Genes
1 Citations

CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

Luo, H., Wang, F., Zha, J., Li, H., Yan, B., Du, Q., Yang, F-C., Sobh, A., Vulpe, C., Drusbosky, L., Cogle, C., Chepelev, I., Xu, B., Nimer, S. D., Licht, J., Qiu, Y., Chen, B., Xu, M. & Huang, S., Aug 23 2018, In : Blood. 132, 8, p. 837-848 12 p.

Research output: Contribution to journalArticle

Transcription
Acute Myeloid Leukemia
Gene expression
Chromatin
Genes

Erratum: CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis (Cancer Cell (2018) 33(6) (1111–1127.e5), (S1535610818302216) (10.1016/j.ccell.2018.05.007))

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathias, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 othersYang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Nov 12 2018, In : Cancer Cell. 34, 5, 1 p.

Research output: Contribution to journalComment/debate

Hematopoiesis
Names
Neoplasms
coactivator-associated arginine methyltransferase 1
11 Citations

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies

Yang, H., Kurtenbach, S., Guo, Y., Lohse, I., Durante, M. A., Li, J., Li, Z., Al-Ali, H., Li, L., Chen, Z., Field, M. G., Zhang, P., Chen, S., Yamamoto, S., Li, Z., Zhou, Y., Nimer, S. D., William Harbour, J., Wahlestedt, C. R., Xu, M. & 1 othersYang, F-C., Jan 18 2018, In : Blood. 131, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

Comb and Wattles
Stem cells
Liquid chromatography
Chromatin
Mass spectrometry