Stephan C Schuerer

Associate Professor

  • 3667 Citations
1996 …2023
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1996 2019

Filter
Article
2019
8 Citations (Scopus)

DrugCentral 2018: an update

Ursu, O., Holmes, J., Bologa, C. G., Yang, J. J., Mathias, S. L., Stathias, V., Nguyen, D. T., Schuerer, S. C. & Oprea, T., Jan 8 2019, In : Nucleic Acids Research. 47, D1, p. D963-D970

Research output: Contribution to journalArticle

Information Storage and Retrieval
United States Food and Drug Administration
Pharmaceutical Preparations
Databases
Literature
Open Access
toxicology
annotations
metadata
Metadata
Toxicology
1 Citation (Scopus)

Novel Curcumin inspired bis-chalcone promotes endoplasmic reticulum stress and glioblastoma neurosphere cell death

Sansalone, L., Veliz, E. A., Myrthil, N. G., Stathias, V., Walters, W., Torrens, I. I., Schürer, S. C., Vanni, S., Leblanc, R. M. & Graham, R. M., Mar 1 2019, In : Cancers. 11, 3, 357.

Research output: Contribution to journalArticle

Open Access
Chalcone
Endoplasmic Reticulum Stress
Curcumin
Glioblastoma
Cell Death
1 Citation (Scopus)

OSCI: Standardized stem cell ontology representation and use cases for stem cell investigation

He, Y., Duncan, W. D., Cooper, D. J., Hansen, J., Iyengar, R., Ong, E., Walker, K., Tibi, O., Smith, S., Serra, L. M., Zheng, J., Sarntivijai, S., Schuerer, S. C., O'shea, K. S. & Diehl, A. D., Apr 25 2019, In : BMC Bioinformatics. 20, 180.

Research output: Contribution to journalArticle

Open Access
Stem Cells
Use Case
Stem cells
Ontology
Cell
2 Citations (Scopus)

Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit

Kepchia, D., Xu, P., Terryn, R., Castro, A., Schuerer, S. C., Leal, W. S. & Luetje, C. W., Dec 1 2019, In : Scientific reports. 9, 1, 4055.

Research output: Contribution to journalArticle

Open Access
Odorant Receptors
Insects
Drosophila melanogaster
Machine Learning
Insect Repellents
2018
7 Citations (Scopus)

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Greenblatt, S. M., Man, N., Hamard, P. J., Asai, T., Karl, D., Martinez, C., Bilbao, D., Stathais, V., McGrew-Jermacowicz, A., Duffort, S., Tadi, M., Blumenthal, E., Newman, S., Vu, L., Xu, Y., Liu, F., Schuerer, S. C., McCabe, M. T., Kruger, R. G., Xu, M. & 5 others, Yang, F-C., Tenen, D., Watts, J., Vega, F. & Nimer, S. D., Jun 11 2018, In : Cancer Cell. 33, 6, p. 1111-1127.e5

Research output: Contribution to journalArticle

Hematopoiesis
Acute Myeloid Leukemia
Cell Cycle
Protein-Arginine N-Methyltransferases
Apoptosis
29 Citations (Scopus)

Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: Integrated access to diverse large-scale cellular perturbation response data

Koleti, A., Terryn, R., Stathias, V., Chung, C., Cooper, D. J., Turner, J. P., VidoviÄ ‡, D., Forlin, M., Kelley, T. T., D'Urso, A., Allen, B. K., Torre, D., Jagodnik, K. M., Wang, L., Jenkins, S. L., Mader, C., Niu, W., Fazel, M., Mahi, N., Pilarczyk, M. & 9 others, Clark, N., Shamsaei, B., Meller, J., Vasiliauskas, J., Reichard, J., Medvedovic, M., Ma'Ayan, A., Pillai, A. & Schuerer, S. C., Jan 1 2018, In : Nucleic Acids Research. 46, D1, p. D558-D566

Research output: Contribution to journalArticle

Libraries
Cataloging
Registries
Software
Databases
5 Citations (Scopus)

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C. H., Lyons, N. J., Wahlestedt, C., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schürer, S. C. & Ayad, N. G., Dec 1 2018, In : Nature Communications. 9, 1, 5315.

Research output: Contribution to journalArticle

Glioblastoma
drugs
signatures
Gene expression
Genes
3 Citations (Scopus)

Far away from the lamppost

Oprea, T. I., Jan, L., Johnson, G. L., Roth, B. L., Ma’ayan, A., Schuerer, S. C., Shoichet, B. K., Sklar, L. A. & McManus, M. T., Dec 1 2018, In : PLoS Biology. 16, 12, e3000067.

Research output: Contribution to journalArticle

Research
funding
Genes
Genome
genome
7 Citations (Scopus)

Polypharmacology or promiscuity? Structural interactions of resveratrol with its bandwagon of targets

Saqib, U., Kelley, T. T., Panguluri, S. K., Liu, D., Savai, R., Baig, M. S. & Schuerer, S. C., Oct 24 2018, In : Frontiers in Pharmacology. 9, OCT, 1201.

Research output: Contribution to journalArticle

Polypharmacology
Proteins
Databases
Stilbenes
Vitis
3 Citations (Scopus)

Sustainable data and metadata management at the BD2K-LINCS Data coordination and integration center

Stathias, V., Koleti, A., Vidovic, D., Cooper, D. J., Jagodnik, K. M., Terryn, R., Forlin, M., Chung, C., Torre, D., Ayad, N., Medvedovic, M., Ma'Ayan, A., Pillai, A. & Schuerer, S. C., Jun 19 2018, In : Scientific data. 5, 180117.

Research output: Contribution to journalArticle

Metadata
Information management
Data Management
Assays
management
2017
11 Citations (Scopus)

Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop

Jagodnik, K. M., Koplev, S., Jenkins, S. L., Ohno-Machado, L., Paten, B., Schuerer, S. C., Dumontier, M., Verborgh, R., Bui, A., Ping, P., McKenna, N. J., Madduri, R., Pillai, A. & Ma'ayan, A., Jul 1 2017, In : Journal of Biomedical Informatics. 71, p. 49-57 9 p.

Research output: Contribution to journalArticle

Biomedical Research
Education
Information Dissemination
Ecosystem
Research Personnel
7 Citations (Scopus)

Drug target ontology to classify and integrate drug discovery data

Lin, Y., Mehta, S., Küçük-McGinty, H., Turner, J. P., Vidovic, D., Forlin, M., Koleti, A., Nguyen, D. T., Jensen, L. J., Guha, R., Mathias, S. L., Ursu, O., Stathias, V., Duan, J., Nabizadeh, N., Chung, C., Mader, C., Visser, U. E., Yang, J. J., Bologa, C. G. & 2 others, Oprea, T. I. & Schuerer, S. C., Nov 9 2017, In : Journal of Biomedical Semantics. 8, 1, 50.

Research output: Contribution to journalArticle

Drug Discovery
Ontology
Pharmaceutical Preparations
Proteins
Genes
6 Citations (Scopus)

From flamingo dance to (desirable) drug discovery: A nature-inspired approach

Sánchez-Rodríguez, A., Pérez-Castillo, Y., Schuerer, S. C., Nicolotti, O., Mangiatordi, G. F., Borges, F., Cordeiro, M. N. D. S., Tejera, E., Medina-Franco, J. L. & Cruz-Monteagudo, M., 2017, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

Drug Discovery
Therapeutic Uses
Industry
Pharmaceutical Preparations
Machine Learning
6 Citations (Scopus)

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations

Allen, B. K., Mehta, S., Ember, S. W. J., Zhu, J. Y., Schönbrunn, E., Ayad, N. & Schuerer, S. C., Jan 1 2017, In : ACS Omega. 2, 8, p. 4760-4771 12 p.

Research output: Contribution to journalArticle

Open Access
Screening
Ligands
Proteins
Molecular dynamics
Computer simulation
5 Citations (Scopus)

Ontological representation, integration, and analysis of LINCS cell line cells and their cellular responses

Ong, E., Xie, J., Ni, Z., Liu, Q., Sarntivijai, S., Lin, Y., Cooper, D., Terryn, R., Stathias, V., Chung, C., Schuerer, S. C. & He, Y., Dec 21 2017, In : BMC Bioinformatics. 18, 556.

Research output: Contribution to journalArticle

Libraries
Signature
Cells
Cell Line
Line
46 Citations (Scopus)

Pharos: Collating protein information to shed light on the druggable genome

Nguyen, D. T., Mathias, S., Bologa, C., Brunak, S., Fernandez, N., Gaulton, A., Hersey, A., Holmes, J., Jensen, L. J., Karlsson, A., Liu, G., Ma'ayan, A., Mandava, G., Mani, S., Mehta, S., Overington, J., Patel, J., Rouillard, A. D., Schuerer, S. C., Sheils, T. & 10 others, Simeonov, A., Sklar, L. A., Southall, N., Ursu, O., Vidovic, D., Waller, A., Yang, J., Jadhav, A., Oprea, T. I. & Guha, R., Jan 1 2017, In : Nucleic Acids Research. 45, D1, p. D995-D1002

Research output: Contribution to journalArticle

Knowledge Management
Genome
Databases
Proteins
Knowledge Bases
12 Citations (Scopus)

Systemic QSAR and phenotypic virtual screening: Chasing butterflies in drug discovery

Cruz-Monteagudo, M., Schuerer, S. C., Tejera, E., Pérez-Castillo, Y., Medina-Franco, J. L., Sánchez-Rodríguez, A. & Borges, F., 2017, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

Butterflies
Quantitative Structure-Activity Relationship
Drug Discovery
Systems Biology
Neuroprotective Agents
5 Citations (Scopus)

TIN-X: target importance and novelty explorer

Cannon, D. C., Yang, J. J., Mathias, S. L., Ursu, O., Mani, S., Waller, A., Schuerer, S. C., Jensen, L. J., Sklar, L. A., Bologa, C. G. & Oprea, T. I., Aug 15 2017, In : Bioinformatics (Oxford, England). 33, 16, p. 2601-2603 3 p.

Research output: Contribution to journalArticle

Proteins
Protein
Receptor
Target
G-Protein-Coupled Receptor Kinases
2016

Building concordant ontologies for drug discovery

Küçük-McGinty, H., Mehta, S., Lin, Y., Nabizadeh, N., Stathias, V., Vidovic, D., Koleti, A., Mader, C., Duan, J., Visser, U. E. & Schuerer, S. C., 2016, In : CEUR Workshop Proceedings. 1747

Research output: Contribution to journalArticle

Ontology
Bioassay
Drug Discovery
Genes
5 Citations (Scopus)

High quality, small molecule-activity datasets for kinase research [version 1; referees: 2 approved]

Sharma, R., Schuerer, S. C. & Muskal, S. M., 2016, In : F1000Research. 5, 1366.

Research output: Contribution to journalArticle

Phosphotransferases
Molecules
Research
Knowledge Bases
Foster Home Care
1 Citation (Scopus)

High quality, small molecule-activity datasets for kinase research [version 2; referees: 2 approved]

Sharma, R., Schuerer, S. C. & Muskal, S. M., 2016, In : F1000Research. 5, 1366.

Research output: Contribution to journalArticle

Phosphotransferases
Molecules
Research
Knowledge Bases
Foster Home Care

The Cell Line Ontology integration and analysis of the knowledge of LINCS cell lines

Ong, E., Xie, J., Ni, Z., Liu, Q., Lin, Y., Stathias, V., Chung, C., Schuerer, S. C. & He, Y., 2016, In : CEUR Workshop Proceedings. 1747

Research output: Contribution to journalArticle

Ontology
Cells
2015
13 Citations (Scopus)

BioAssay Research Database (BARD): Chemical biology and probe-development enabled by structured metadata and result types

Howe, E. A., De Souza, A., Lahr, D. L., Chatwin, S., Montgomery, P., Alexander, B. R., Nguyen, D. T., Cruz, Y., Stonich, D. A., Walzer, G., Rose, J. T., Picard, S. C., Liu, Z., Rose, J. N., Xiang, X., Asiedu, J., Durkin, D., Levine, J., Yang, J. J., Schuerer, S. C. & 10 others, Braisted, J. C., Southall, N., Southern, M. R., Chung, T. D. Y., Brudz, S., Tanega, C., Schreiber, S. L., Bittker, J. A., Guha, R. & Clemons, P. A., Jan 28 2015, In : Nucleic Acids Research. 43, D1, p. D1163-D1170

Research output: Contribution to journalArticle

Chemical Databases
Biological Assay
Databases
Research
Research Personnel

Editor's Choice: Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. iii

Research output: Contribution to journalArticle

5 Citations (Scopus)

Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

Allen, B. K., Stathias, V., Maloof, M. E., Vidovic, D., Winterbottom, E. F., Capobianco, A. J., Clarke, J., Schuerer, S. C., Robbins, D. J. & Ayad, N., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 351-363 13 p.

Research output: Contribution to journalArticle

DNA sequences
Cell proliferation
Drug Combinations
Glioblastoma
Epigenomics
3 Citations (Scopus)

GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation

Penas, C., Mishra, J. K., Wood, S. D., Schuerer, S. C., Roush, W. R. & Ayad, N., Feb 1 2015, In : Cell Cycle. 14, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

Cell Cycle
Cell Proliferation
Interphase
S Phase
Mitosis
27 Citations (Scopus)

Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

Allen, B. K., Mehta, S., Ember, S. W. J., Schonbrunn, E., Ayad, N. & Schuerer, S. C., Nov 24 2015, In : Scientific Reports. 5, 16924.

Research output: Contribution to journalArticle

Phosphotransferases
Neoplasms
Drug Design
Epigenomics
Therapeutics
20 Citations (Scopus)

Noribogaine is a G-protein biased κ-opioid receptor agonist

Maillet, E. L., Milon, N., Heghinian, M. D., Fishback, J., Schuerer, S. C., Garamszegi, N. & Mash, D. C., Dec 1 2015, In : Neuropharmacology. 99, p. 675-688 14 p.

Research output: Contribution to journalArticle

Opioid Receptors
GTP-Binding Proteins
Dynorphins
Ibogaine
Arrestin
1 Citation (Scopus)

Screening of cell cycle fusion proteins to identify kinase signaling networks

Trojanowsky, M., Vidovic, D., Simanski, S., Penas, C., Schuerer, S. C. & Ayad, N., Apr 15 2015, In : Cell Cycle. 14, 8, p. 1274-1281 8 p.

Research output: Contribution to journalArticle

Cell Cycle Proteins
Cell Fusion
Phosphotransferases
Luciferases
Ubiquitin
10 Citations (Scopus)

Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

Abdul-Hay, S. O., Bannister, T. D., Wang, H., Cameron, M. D., Caulfield, T. R., Masson, A., Bertrand, J., Howard, E. A., McGuire, M. P., Crisafulli, U., Rosenberry, T. R., Topper, C. L., Thompson, C. R., Schuerer, S. C., Madoux, F., Hodder, P. & Leissring, M. A., Dec 18 2015, In : ACS Chemical Biology. 10, 12, p. 2716-2724 9 p.

Research output: Contribution to journalArticle

Insulysin
Sulfhydryl Compounds
Extracellular Space
Peptide Hydrolases
Enzymes
11 Citations (Scopus)

Using the BioAssay Ontology for analyzing high-throughput screening data

Zander Balderud, L., Murray, D., Larsson, N., Vempati, U., Schuerer, S. C., Bjäreland, M. & Engkvist, O., Mar 25 2015, In : Journal of Biomolecular Screening. 20, 3, p. 402-415 14 p.

Research output: Contribution to journalArticle

Bioassay
Biological Assay
Ontology
Assays
Screening
2014
171 Citations (Scopus)

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress

Ghosh, R., Wang, L., Wang, E. S., Perera, B. G. K., Igbaria, A., Morita, S., Prado, K., Thamsen, M., Caswell, D., Macias, H., Weiberth, K. F., Gliedt, M. J., Alavi, M. V., Hari, S. B., Mitra, A. K., Bhhatarai, B., Schuerer, S. C., Snapp, E. L., Gould, D. B., German, M. S. & 4 others, Backes, B. J., Maly, D. J., Oakes, S. A. & Papa, F. R., Jul 31 2014, In : Cell. 158, 3, p. 534-548 15 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Ribonucleases
Oligomerization
Cell Survival
Cells
18 Citations (Scopus)

An overview of the challenges in designing, integrating, and delivering BARD: A public chemical-biology resource and query portal for multiple organizations, locations, and disciplines

De Souza, A., Bittker, J. A., Lahr, D. L., Brudz, S., Chatwin, S., Oprea, T. I., Waller, A., Yang, J. J., Southall, N., Guha, R., Schuerer, S. C., Vempati, U. D., Southern, M. R., Dawson, E. S., Clemons, P. A. & Chung, T. D. Y., Jan 1 2014, In : Journal of Biomolecular Screening. 19, 5, p. 614-627 14 p.

Research output: Contribution to journalArticle

Bioassay
Biological Assay
Organizations
Databases
Assays
15 Citations (Scopus)

Casein kinase 1-dependent wee1 protein degradation

Penas, L., Ramachandran, V., Simanski, S., Lee, C., Madoux, F., Rahaim, R. J., Chauhan, R., Barnaby, O., Schuerer, S. C., Hodder, P., Steen, J., Roush, W. R. & Ayad, N., Jul 4 2014, In : Journal of Biological Chemistry. 289, 27, p. 18893-18903 11 p.

Research output: Contribution to journalArticle

Casein Kinase I
Protein Kinases
Proteolysis
Cell Cycle
Phosphotransferases
42 Citations (Scopus)

CLO: The cell line ontology

Sarntivijai, S., Lin, Y., Xiang, Z., Meehan, T. F., Diehl, A. D., Vempati, U. D., Schuerer, S. C., Pang, C., Malone, J., Parkinson, H., Liu, Y., Takatsuki, T., Saijo, K., Masuya, H., Nakamura, Y., Brush, M. H., Haendel, M. A., Zheng, J., Stoeckert, C. J., Peters, B. & 5 others, Mungall, C. J., Carey, T. E., States, D. J., Athey, B. D. & He, Y., Aug 13 2014, In : Journal of Biomedical Semantics. 5, 1, 37.

Research output: Contribution to journalArticle

Ontology
Cells
Cell Line
Biomedical Research
Vaccines
43 Citations (Scopus)

Evolving BioAssay Ontology (BAO): Modularization, integration and applications

Abeyruwan, S., Vempati, U. D., Küçük-McGinty, H., Visser, U. E., Koleti, A., Mir, A., Sakurai, K., Chung, C., Bittker, J. A., Clemons, P. A., Brudz, S., Siripala, A., Morales, A. J., Romacker, M., Twomey, D., Bureeva, S., Lemmon, V. & Schuerer, S. C., 2014, In : Journal of Biomedical Semantics. 5, S5.

Research output: Contribution to journalArticle

Bioassay
Biological Assay
Ontology
Preclinical Drug Evaluations
Assays
12 Citations (Scopus)

Fast and accurate semantic annotation of bioassays exploiting a hybrid of machine learning and user confirmation

Clark, A. M., Bunin, B. A., Litterman, N. K., Schuerer, S. C. & Visser, U. E., 2014, In : PeerJ. 2014, 1, e524.

Research output: Contribution to journalArticle

Bioassay
artificial intelligence
Semantics
Biological Assay
Learning systems
43 Citations (Scopus)
Libraries
Genome
Growth
Pharmaceutical Preparations
Pharmacologic Actions
53 Citations (Scopus)

Metadata standard and data exchange specifications to describe, model, and integrate complex and diverse high-throughput screening data from the library of integrated network-based cellular signatures (LINCS)

Vempati, U. D., Chung, C., Mader, C., Koleti, A., Datar, N., Vidović, D., Wrobel, D., Erickson, S., Muhlich, J. L., Berriz, G., Benes, C. H., Subramanian, A., Pillai, A., Shamu, C. E. & Schuerer, S. C., Jan 1 2014, In : Journal of Biomolecular Screening. 19, 5, p. 803-816 14 p.

Research output: Contribution to journalArticle

Electronic data interchange
Metadata
Libraries
Screening
Throughput
2013
28 Citations (Scopus)

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis

Wolfe, L. M., Veeraraghavan, U., Idicula-Thomas, S., Schuerer, S. C., Wennerberg, K., Reynolds, R., Besra, G. S. & Dobos, K. M., Jun 1 2013, In : Molecular and Cellular Proteomics. 12, 6, p. 1644-1660 17 p.

Research output: Contribution to journalArticle

Proteome
Mycobacterium tuberculosis
Proteomics
Adenosine Triphosphate
Enzyme Inhibitors
30 Citations (Scopus)

A sphingosine 1-phosphate receptor 2 selective allosteric agonist

Satsu, H., Schaeffer, M. T., Guerrero, M., Saldana, A., Eberhart, C., Hodder, P., Cayanan, C., Schuerer, S. C., Bhhatarai, B., Roberts, E., Rosen, H. & Brown, S. J., Sep 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5373-5382 10 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Chemical activation
Molecular Probes
Biological Phenomena
Fibroblasts
28 Citations (Scopus)

Chemical interrogation of the neuronal kinome using a primary cell-based screening assay

Al-Ali, H., Schuerer, S. C., Lemmon, V. & Bixby, J., May 17 2013, In : ACS Chemical Biology. 8, 5, p. 1027-1036 10 p.

Research output: Contribution to journalArticle

Assays
Screening
Axons
Growth
Neurites
29 Citations (Scopus)

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties

Bibian, M., Rahaim, R. J., Choi, J. Y., Noguchi, Y., Schuerer, S. C., Chen, W., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., Feng, Y., Cameron, M. D., Duckett, D. R., Cleveland, J. L. & Roush, W. R., Aug 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 15, p. 4374-4380 7 p.

Research output: Contribution to journalArticle

Casein Kinase I
Cells
Lead compounds
Cell Line
Heterografts
29 Citations (Scopus)

GPCR ontology: development and application of a G protein-coupled receptor pharmacology knowledge framework.

Przydzial, M. J., Bhhatarai, B., Koleti, A., Vempati, U. & Schuerer, S. C., Dec 15 2013, In : Bioinformatics (Oxford, England). 29, 24, p. 3211-3219 9 p.

Research output: Contribution to journalArticle

Pharmacology
G Protein
G-Protein-Coupled Receptors
Receptor
Ontology
33 Citations (Scopus)

Kinome-wide activity modeling from diverse public high-quality data sets

Schuerer, S. C. & Muskal, S. M., Jan 28 2013, In : Journal of Chemical Information and Modeling. 53, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

data quality
Phosphotransferases
Molecules
Standardization
Assays
2012
449 Citations (Scopus)

Crystal structure of a lipid G protein-coupled receptor

Hanson, M. A., Roth, C. B., Jo, E., Griffith, M. T., Scott, F. L., Reinhart, G., Desale, H., Clemons, B., Cahalan, S. M., Schuerer, S. C., Sanna, M. G., Han, G. W., Kuhn, P., Rosen, H. & Stevens, R. C., Feb 17 2012, In : Science. 335, 6070, p. 851-855 5 p.

Research output: Contribution to journalArticle

Protein
Lipids
Crystal
Phosphate
Cells
101 Citations (Scopus)

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Wang, L., Perera, B. G. K., Hari, S. B., Bhhatarai, B., Backes, B. J., Seeliger, M. A., Schuerer, S. C., Oakes, S. A., Papa, F. R. & Maly, D. J., Dec 1 2012, In : Nature Chemical Biology. 8, 12, p. 982-989 8 p.

Research output: Contribution to journalArticle

Endoribonucleases
Ribonucleases
Endoplasmic Reticulum Stress
Phosphotransferases
Unfolded Protein Response
3 Citations (Scopus)

Exploratory computational assessment of possible binding modes for small molecule inhibitors of the CD40-CD154 co-stimulatory interaction

Ganesan, L., Vidović, D., Schuerer, S. C. & Buchwald, P., Jun 21 2012, In : Pharmazie. 67, 5, p. 374-379 6 p.

Research output: Contribution to journalArticle

Binding Sites
Allosteric Site
Competitive Binding
Proteins
Coloring Agents
36 Citations (Scopus)

Formalization, Annotation and Analysis of Diverse Drug and Probe Screening Assay Datasets Using the BioAssay Ontology (BAO)

Vempati, U. D., Przydzial, M. J., Chung, C., Abeyruwan, S., Mir, A., Sakurai, K., Visser, U. E., Lemmon, V. & Schuerer, S. C., Nov 14 2012, In : PLoS One. 7, 11, e49198.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Bioassay
Biological Assay
probes (equipment)
Ontology